Reading material for this lecture:

1
Reading material for this lecture This lecture
itself. Database statistics http//www.ebi.ac.u
k/embl/
Structure of the amino-terminal domain of Cbl
complexed to its binding site on ZAP-70 kinase
Wuyi Meng, Sansana Sawasdikosol, Steven J.
Burakoff, Michael J. EckNature 398, 84 - 90 (04
March 1999)(available on-line at www.nature.com
- search for ZAP-70 kinase - republished in
December on-line)
Protein recognition An SH2 domain in disguise
John Kuriyan, James E. DarnellNature 398, 22 -
25 (04 March 1999) (news and views article for
above paper)
Russell, R. B. and Barton, G. J. (1993), "An
SH2-SH3 Domain hybrid", Nature, 364, 765.
Matthews, S., et al. (1994), "The p17 Matrix
Protein from HIV-1 is Structurally Similar to
Interferon-gamma", Nature, 370, 666-668.
Barton, G. J., Cohen, P. T. C. and Barford, D.
(1994),"Conservation Analysis and Structure
Prediction of the Protein Serine/Threonine
Phosphatases Sequence Similarity with
Diadenosine Tetra-phosphatase fromE. coli
Suggests Homology to the Protein Phosphatases",
Eur. J. Biochem.,220, 225-237.
2
Reading material for this lecture http//www.ncbi
.nlm.nih.gov - look at BLAST service. http//www
.ebi.ac.uk/ - look at Tools, in particular SRS
and CLUSTAL.
Book chapter (online) http//www.compbio.dund
ee.ac.uk/papers/rev93_1/rev93_1.html Same
information in PDF File http//www.compbio.dunde
e.ac.uk/ftp/preprints/review93/review93.pdf