INVIGORATE

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INVIGORATE

• The Natural Alternative In
• Joint Care
• INVIGORATE
• veterinary products
• from
• Creative Labs Inc.
• Newburg, WI.

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Is Arthritis A problem?

• Joint disease is a major cause of distress to
  millions of dogs throughout the Western world.

• In the USA 8 million dogs suffer from arthritis

• Over 50 of these arthritic dogs go untreated
• One out of five dogs experience arthritis

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What Is Arthritis?

• Arthritis is Inflammation of a Joint and
  Surrounding Tissues.

There Are Two Major Types of Arthritis-1.
Rheumatoid 2. Osteoarthritis
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Mechanism of Arthritis

• Cartilage degenerates.
• No pain receptors in cartilage.
• Severe inflammation of joint and soft tissues.
• Sub-chondral bone breaks down.
• Joint deformation occurs.
• Bony splinters break-off.
• Joint becomes increasingly immobile.
• Further inflammation occurs.

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Symptoms Of Arthritis

• In The Early Disease Process.
• Joint pain.
• Inflammation.
• Loss of joint cartilage.
• In Chronic Forms.
• Synovitis and joint enlargement.
• Deformity, immobility.

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Management of Arthritis

• First priority is to
• Decrease inflammatory responses and pain to
  maintain mobility.
• Long-term support.
• Weight control
• Controlled exercise
• Support for longer-term.

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Clinical Management

• Typically Involves.
• Anti-inflammatories (NSAIDs).
• Patient Advice, physiotherapy etc.
• There are a number of NSAIDs.
• How do they work?
• Are they dangerous

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Where Does INVIGORATE Fit IN?

• INVIGORATE is A New Dual Action Nutraceutical
  Supplement In Joint Care.
• INVIGORATE provides both anti-inflammatory and
  chondro-protective nutrients in ONE Supplement.

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How Is INVIGORATE Grown?

• INVIGORATE is produced in the Pacific Ocean
  under strict conditions.
• Government controlled.
• Environmentally sustainable.
• Human health standards.
• In water tested and monitored daily!

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How Are INVIGORATE Mussels Grown?

• INVIGORATE mussels are produced under Government
  License and To Government GMP/COSH standards.
• They are grown on ropes inside cotton sheaths.
• The tiny mussels attach to algae on the ropes and
  stick there.
• They are harvested after 12 18 months.

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How Is INVIGORATE Manufactured?

• The mature mussels are collected and chilled to
  below 4oc within 2-4 hours.
• The whole process is below 4oc.
• They are separated from shells and washed a
  number of times with various natural stabilizers
  found in the mussels.
• They are GENTLY freeze dried as laboratory
  enzymes would be.

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What Makes INVIGORATE Different?

• The special processing methods produce high
  yields of Poly-unsaturated Fatty Acids (PUFAs).
• These include Special, only recently discovered
  (identified in the mid 1990s) ETAs or
  Eicosatetraenoic Acids.
• ETAs are Omega-3 series PUFAs similar in
  structure to Arachidonic Acid which is an Omega-6
  structure.
• There in lies the difference!!
• Because ETAs are Omega-3 PUFAs they have a
  potent anti-inflammatory effect on the pathways
  causing inflammation.

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Major Inflammatory pathways.

• There are 2 pathways
• Both start with Arachidonic Acid which is
  essential to health and found in all cells.
• Both produce chemicals which cause inflammation,
  swelling and pain.
• Cyclo-oxygenase.
• Lipoxygenase.

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INVIGORATE - Potent Anti-inflammatory

• ETAs Independent Scientific Publications
• Used established pharmacological and biochemical
  methods.
• In vivo rat paw edema test.
• In vitro studies measuring production of
  Prostaglandins and Leukotrienes.
• Two publications in three years confirm activity.
• Inflammopharmacology, 1997.
• Townsend Papers For Doctors (USA), May 2000.
• ETAs act as Anti-metabolites of Arachidonic Acid.

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ETAs And Other NSAIDs Activity
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ETAs Whats The Evidence?

• In Vitro
• Inhibits production of COX II prostaglandins
• Inhibits production of Lipoxygenase Leukotrienes.
• In Vivo
• Potent anti-inflammatory properties.
• NO EFFECT upon Platelets or Stomach in high doses
  in humans and animals. Therefore no effect upon
  COX I.

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• In Vivo
• Rat paw edema test shows potent anti-swelling
  effects similar or better than many existing well
  known OTC products like aspirin and ibuprofen.

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Technical features Of INVIGORATE

• Contains a cold processed extract of Perna
  canaliculus.
• Proven anti-inflammatory / Chondro-protective.
• Provides extremely valuable Omega-3 PUFA
  Eicosatetraenoic acids (ETAs), which are potent
  inhibitors of the Cyclo-oxygenase and
  Lipoxygenase pathways.
• Exerts a potent anti-inflammatory analgesic
  effect.
• Provides the necessary Chondro-protective
  building blocks to rebuild damaged cartilage in
  the form of Glycosaminoglycans (GAGs).

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Compared To Other Supplements
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Compared To Other Mussel Products

• INVIGORATE contains between 5 and 15 more ETAs
  than any other mussel powder.

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Chondro-Protection

• Perna products contain their own own natural
  range of Glycosaminoglycans (GAGs) such as
  glucosamine, chondroitins, heparans.
• Perna products contain all of the
  chondro-protective components needed to help slow
  or prevent joint degeneration.
• An Independent Study confirmed the long-term
  benefits of Perna products.
• Townsend Letters For Doctors (USA) July 2000.
• This paper included before and after X-ray
  analysis.

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Gonarthrosis Study5

• A study of 120 patients suffering X Ray confirmed
  arthritis of the knee. Patients, the majority of
  which were candidates for surgery, were assessed
  for
• Pain Hutchinson Visual Analogue Pain Scale
• Biomechanical Adjustment shoe adjustments.
• Inflammatory Index Clinical evaluation of
  swelling, trauma, redness, pain and heat
• Daily Activity Minutes of morning stiffness,
  golf, walking etc.
• Compliance and Medication
• X-Ray Evaluation 2 months, six months and one
  year using a standardized, reproducible technique
  per patient.
• X-Rays were graded on the Kellgren and Lawrence
  System.

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Gonarthrosis Study Results5

• Generally, Grade I and II patients reporting a
  VAS of 7 reported a 0 to 2 VAS at the first
  follow up visit.
• Remained comfortable and active for the rest of
  the study.
• Swelling, pain and heat notably diminished during
  the study.
• The two patients requiring canes no longer needed
  them.
• There was no correlation between sexes, age, genu
  varus or genu valgus.
• Grades I and II responded better than III and IV
  (bone to bone contact).
• Many patients reduced NSAID intake by 50
• Eight patients showed a reversal of joint space
  narrowing on follow-up X-rays.!!
• No Grade I or II patients showed any continuing
  X-ray deterioration over the course of the year.
• X-Ray finings strongly suggest an anabolic effect
  stimulating chondrogenesis.

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Medical Publications

• Double-Blind Trial Of Patients With Knee
  Arthritis9
• Double-Blind versus placebo over 6 months.
• 62 experienced significant reduction in pain
  over 6 months.

• Statistically significant results
• Pain and discomfort
• Functional Index
• Patients opinion of results
• Doctors assessment

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Medical Publications

• 1998. Randomised Trial in Rheumatoid and
  Osteoarthritic patients. 11
• Double-Blind Comparison of whole stabilised
  powder and separated ETAs in 60 chronic patients
  for 6months.

• Assessments
•  AI Articular Index of joint stiffness
• LU Limbering up time
• VA Grip strength in each hand.
• FUI Functional Index.

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1998 Glasgow Trial Results

• Overall, 76 of rheumatoid and 70 of
  osteoarthritic patients benefited and improved.
• Statistically significant improvements were seen
  in Functional Index and Articular Index after
  only one month.
• AI LUT and FI statistically significantly
  improved over 3 months.
• Grip straight improved in many individuals but
  not significantly as a whole group.
• No adverse affects were observed.
• No changes in blood profile were observed

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Safety profile vs. NSAIDs

• Concerns or Problems Of Side-effects
• NSAID JOINT-AID
• Gastro-toxicity yes no
• Platelet aggregation yes no
• Liver Disease yes no
• Renal problems yes no

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NSAIDs And Safety

• A 1997 study investigating the association of
  upper gastro-intestinal toxicity of NSAIDs with
  their continued exposure concluded that,
• .. toxicity persisted with continuous use of
  these drugs and that there seem to be carry-over
  toxicity after the end of prescribing2
•  Another paper.
• This gastro-toxicity has led to NSAIDs being the
  most widely reported drug cause of adverse
  events.3.
•  In 2000,
• A recent report indicated that up to 2,000 people
  a year die from the side effects of NSAIDs 4.

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How Does INVIGORATE Compare With Glucosamine Type
products?

• Glucosamine and chondroitin are being promoted
  for Joint Care.
• Glucosamine will have an effect BUT is slow and
  may not be obvious for 3 months.
• Even Glucosamine products instructions state
  if no effect is seen in 6 weeks keep giving the
  large starting dose.
• Glucosamine is a cartilage nutrient and has to be
  metabolised in the joints.
• Glucosamine is useful but only over the
  long-term.
• Glucosamine has no anti-inflammatory activity.
• Chondroitin is a very large molecule broken down
  by digestion.
• The role of chondroitin is not universally
  supported scientifically.
• Chondroitin is made in the body anyway from
  nutrients like glucosamine.
• Chondroitin is produced from Bovine, Porcine
  lungs and tracheas and Shark Cartilage!!
• Catching sharks for cartilage is banned now in
  the USA.

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INVIGORATE in Summary

• Pronounced anti-inflammatory activity- works
  within the first seven to ten days.
• Contains higher quantities Omega-3
  Polyunsaturated Fatty Acids (PUFAs).
• These are known as Eicosatetraenoic Acids or
  ETAs for short.
• Extensive independent scientific studies have
  shown excellent results, even when compared to
  well known pharmaceutical compounds.
• Medical studies has shown that products such as
  INVIGORATE soothe stiff joints and help maintain
  optimum mobility. INVIGORATE produces visible
  mobilisation, usually within the first two weeks
  which continues over time.
• Recent studies have demonstrated great benefits
  of INVIGORATE over long-term use helping to
  prevent joint deterioration and even reverse
  joint damage.

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INVIGORATE raw material is produced in the
Pacific Ocean under strict conditions, Govern
ment controlled Environmentally
sustainable Human health standards In water
tested and monitored daily! Each
bay is chosen for water cleanliness and rich
nutrients. We have our own dedicated Mussel
farms to ensure high quality. We have invested
in our own factory to ensure our methods are
protected and we can supply to
forecast.
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How Are INVIGORATE Mussels Grown? INVIGORATE
mussels are produced under Government License and
To Government GMP/COSH standards. They are
grown on ropes inside cotton sheaths. The tiny
mussels attach to algae on the ropes and stick
there. They are harvested after 12 18
months.
The ropes are suspended vertically from
floating booms.
It takes 8 tons of mussel meat to
produce 1 ton of INVIGORATE.
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How is INVIGORATE manufactured? The
mature mussels are collected and chilled to below
4oc within 2-4 hours. The
Temperature is kept below 4oc for our whole
process. Steam is never used to



extract the mussel thus the percent of
Fatty Acids in INVIGORATE remains much higher
than


the competition.
The mussels are separated from shells and washed
a number of times with various



natural stabilizers. In the final
process, they are GENTLY freeze dried.
Because of the combination of cold
processing and stabilization, we can ensure that
our Mussels contain a much higher quantity of the
important Fatty Acids (ETAs) than any of the
competition. This process is exclusively used by
our company to produce our INVIGORATE.
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