Introduction to biological thermodynamics' Entropy, temperature and free energy

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Biological and Medical Physics PHY 615
Student Presentation (Lecture 22)Lab-on-Chip
Technology November 15th, 2007 Philip
Rafferty plraffer_at_syr.edu
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Biological and Medical Physics - PHY 615 -
Lecture 22
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A Short History of LOC

• Once miniaturization was discovered (late
  1950s), many devices were developed. First were
  electrical, then mechanical. Examples
  electrical and pressure sensors.
• 1975 - S.C. Terry of Stanford developed a gas
  chromatograph on LOC technology (silicon wafer).
• Late 1980s - 1990s Explosion in LOC
  Development/Use mainly in microfluidics
  (flowsensors, micropumps, etc).
• 1990s Advancements in Genomics made possible by
  LOC technology (capillary electrophoresis, etc.).
  Governmental interest for weapons/chemical
  detection systems (portable systems).
• Still a very novel technology.

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Pros and Cons

• Very low volume required.
• Very low volume consumed.
• High analysis control (heat, distance, mixing
  times, reaction speed).
• Fast system response (due to high analysis
  control).
• Rapid analysis of many samples/tests in parallel.
• Safety.
• Size.
• Disposable.
• New Technology.
• Smaller size/volume has different set of rules
  than full scale laboratory interactions.
• Often have high noise.
• Sample preparation.
• Reliability, Sensitivity, and Accuracy.

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Major Source

• Monthly, peer-reviewed publication.
• Can be accessed through SUs Online Library
  Database.

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Literature Discussion 1
Leach, J. et al, Lab-on-Chip, 2006, v6, p735-739
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Literature Discussion 1, cont.
Leach, J. et al, Lab-on-Chip, 2006, v6, p735-739
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Literature Discussion 1, cont.
Leach, J. et al, Lab-on-Chip, 2006, v6, p735-739
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Literature Discussion 2
Brunner, C. et al, Lab-on-Chip, 2007, v7,
p1263-1271
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Literature Discussion 2
Brunner, C. et al, Lab-on-Chip, 2007, v7,
p1263-1271
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Literature Discussion 2, cont.
Brunner, C. et al, Lab-on-Chip, 2007, v7,
p1263-1271
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Literature Discussion 2, cont.
Brunner, C. et al, Lab-on-Chip, 2007, v7,
p1263-1271
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Literature Discussion 3
Zagnoni, M. et al, Lab-on-Chip, 2007, v7,
p1176-1183
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Literature Discussion 3, cont.
Zagnoni, M. et al, Lab-on-Chip, 2007, v7,
p1176-1183
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Biological and Medical Physics - PHY 615
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Literature Discussion 3, cont.
Zagnoni, M. et al, Lab-on-Chip, 2007, v7,
p1176-1183
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Literature Discussion 3
Zagnoni, M. et al, Lab-on-Chip, 2007, v7,
p1176-1183
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Biological and Medical Physics - PHY 615
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Literature Discussion 3, cont.
Zagnoni, M. et al, Lab-on-Chip, 2007, v7,
p1176-1183
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References

• Brunner, C., Wahnes, C., Vogel, V. (2007).
  Cargo Pick-Up From Engineered Loading Stations by
  Kinesin Driven Molecular Shuttles. Lab-On-Chip,
  v7, 1236-1271.
• Leach, J., Mushfique, H., Leonardo, R., Padgett,
  M., Cooper, J. (2006). An Optically Driven Pump
  for Microfluidics. Lab-On-Chip, v6, 735-739.
• Zagnoni, M., Sandison, M.E., Marius, P., Lee,
  A.G., Morgan, H. (2007). Controlled Delivery of
  Proteins into Bilayer Lipid Membranes on Chip.
  Lab-On-Chip, v7, 1176-1183.
• Lab-on-a-chip. (2007, November 10). In Wikipedia,
  The Free Encyclopedia. Retrieved from
  http//en.wikipedia.org/w/index.php
  ?titleLab-on-a-chipoldid170549425

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