Histology of the Male Reproductive System (Repro 5)

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Histology of the Male Reproductive System(Repro
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• PROF. DR. FAUZIAH OTHMAN
• DEPT OF HUMAN ANATOMY

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Contents

• Histology of testes
• Histology of vas deferens
• Histology of seminal vesicle
• Histology of prostate gland
• Histology of the Bulbourethral gland

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Histology of testes
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• Tunica albuginea-
• dense white fibrous capsule
• composed of dense irregular connective tissue,
• forming septa that divide each testis into series
  internal compartments called lobules.

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Spermatogenesis in seminiferous tubules
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Seminiferous tubules

• Stratified germinal epithelium
• Surrounded by a layer CT with fibroblast and an
  inner basement membrane (bm).
• Consist Supporting (Sertoli cell)
• Slender, elongated cells with irregular outlines
  that extend from the bm.
• Primary spermatocytes
• Spermatocytes
• Spermatids

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Spermatogenesis

• Process where the spermatogenic cells in the
  seminiferous tubules divide, differentiate, and
  produce sperm.
• 3 phases
• Mitotic division of spermatogonia
• Meiotic division of spermatocytes, somatic
  chromosome no. spermatids
• Spermiogenesis morphological transformation
  spermatids sperm.

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Testes produce both testosterone and sperm

• LH and FSH are produced by the pituitary gland.
• LH binds to receptors on the interstitial cells
  (Leydig cells) and stimulate testosterone.
• FSH stimulates Sertoli cells to synthesize and
  release ABP (androgen-binding protein) into
  seminiferous tubules to stimulate
  spermatogenesis.
• ? concentration of testosterone essential for
  proper spermatogenesis.

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Sertoli cells

• Supportive cells in the seminiferous tubules
  located among the spermatogenic cells
• Fx physical support, protection and nutrition of
  the developing sperm (spermatids)
• Phagocytosis of cytoplasm developing sperm
  (spermatids)
• Produce and release ABP.

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Seminiferous tubule, straight tubules, rete
testis ductuli efferentes
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Ductuli efferentes of the ductus epididymis
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Histology of vas deferens
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Vas deferens

• A narrow and irregular lumen with longitudinal
  mucosal folds.
• Psuedostratified columnar epithelium with
  stereocilia.
• Thin lamina propria
• consists of compact colagen fibers and fie net
  work of elastic fibers.
• Thick muscularis
• 3 SM layers
• Inner longitudinal
• Middle circular
• Outer longitudinal
• Adventitia.
• Abundant of blood vessels

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Ampulla of the vas deferens

• Terminal portion of the vas deferens enlarges
  into an ampulla
• Lumen of ampulla larger than vas deferens.
• Numerous irregular branching mucosal folds
• Deep glandular diverticula or crypts
• Simple columnar or cuboidal epithelium.
• Lamina propria
• 3 layers of SM
• Thin inner longitudinal
• Thick middle circular
• Thin outer longitudinal

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Ampulla of the vas deferens
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Accessory reproductive glands

• Seminal vesicles
• Yellowish viscous fluid high in fructose
• Energy source for sperm motility
• Produce most fluid found in semen
• Prostate gland
• Porduce thin, watery slightly acidic fluid
• The enzyme fibrinolysin liquefies the semen after
  ejaculation.
• Bulbourethral glands
• Produce clear, viscid, mucus-like secretion
  during erotic stimulation
• As lubricant for thr penile urethra.

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Histology of seminal vesicle
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Glandular epithelium of seminal vesicles normally
varies low pseudostratified, low columnar or
cuboidal.
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Prostate gland prostate urethra
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• Prostate gland
• Prostetic urethra
• Psuedostratified epithelium
• Glandular acini vary in size
• Lumina of acini normally wide and irregular
• Protrusion of epithelium-covered connective
  tissue folds
• Proteinaceous secretions sometimes prostatic
  concretions.
• Glandular epithelium simple-columnar or psuedot
  Fibromuscular stroma
• Characteristic feature of prostate gland
• SM bundles and CT fibers blend together in the
  stroma throughout the gland.
• ratified, cells lightly stain, some region
  squamous or cuboidal.

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Histology of prostate gland
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Histology of the Bulbourethral gland