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Chronic Kidney Disease For the PCM

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Title: Chronic Kidney Disease For the PCM


1
Chronic Kidney DiseaseFor the PCM
  • YOU Can Make a Difference!

2
Goals and Objectives
  • Review the K/DOQI definition and classification
    of chronic kidney disease (CKD)
  • Review the prevalence and causes of CKD in the
    US.
  • Understand the primary evaluation and management
    of patients with CKD.

3
Defining CKD
  • Kidney damage for 3 months, defined by
    structural or functional abnormalities of the
    kidney, with or without decreased GFR, manifest
    by either
  • Pathologic abnormalities, or
  • Markers of kidney damage, such as abnormalities
    of the blood or urine, or in imaging tests (but
    NOT HTN).
  • GFR lt 60 mL/min/1.73 m2 for 3 months with or
    without kidney damage.

4
Defining Kidney Damage
  • Pathologic Abnormalities?
  • By Radiology (US, CT, MR, etc)--e.g.
  • Multiple cysts consistent with PKD
  • Extensive scarring
  • Small kidneys--but be careful of the term
    medical renal disease.
  • REMEMBER Renal masses or cysts that are not
    simple should be referred to a UROLOGIST!!
  • By Histology--ie, renal biopsy

5
Defining Kidney Damage
  • Markers of Kidney Damage?
  • Proteinuria
  • Microalbuminuria
  • Hematuria (especially when seen with proteinuria)
  • Isolated hematuria has a long differential
    infection, stone, malignancy, etc.
  • Casts (especially with cellular elements)

6
NKF-K/DOQI Stages of CKD
Stage Description GFR (mL/min/1.73m2)
1 Kidney damage with normal or ? GFR gt 90
2 Mild ? GFR 60-89
3 Moderate ? GFR 30-59
4 Severe ? GFR 15-29
5 Kidney Failure lt 15 or dialysis
Primary Care Focus is here!
7
Prevalence of GFR Categories in the USA(There is
a lot of CKD!)
Stage 3 CKD
8
Prevalence of CKD by GFR in the USA(There is a
lot of CKD!)
Stage Description GFR (mL/min/1.73m2) Prevalence Prevalence ()
1 Kidney damage with normal or ? GFR gt 90 5.9 million 3.3
2 Mild ? GFR 60-89 5.3 million 3.0
3 Moderate ? GFR 30-59 7.6 million 4.3
4 Severe ? GFR 15-29 400,000 0.2
5 Kidney Failure lt 15 or dialysis 300,000 0.2
Coresh, et al, Am J Kidney Dis. 2003 41 1-12
9
Causes of ESRD in the USA Prevalent Counts and
Adjusted Rates by Primary Diagnosis
2006 ADR USRDS
10
Trends in the size of the Medicare CKD
population, by diabetic statusFigure 1.1
USRDS
700,000
600,000
Non-diabetic
500,000
en
f
400,000
b
Diabetic
300,000
num
And the numbers are increasing
200,000
ma
s
E
100,000
0
92-93
93-94
94-95
95-96
96-97
97-98
98-99
99-00
00-01
Cohort defining Period
Patients continuously enrolled in Medicare Part A
Part B in any two consecutive calendar years
from 1992 to 2001 (entry period), alive on the
last day of the entry period. Patients enrolled
in an HMO or diagnosed with ESRD any time during
the entry period are excluded. Estimates of the
general Medicare population are based on the 5
percent Medicare sample.
11
CKD Patients Are More Likely to Die than to
Progress to ESRD
5 year follow-up
N27998
Keith, et al, Arch Int Med 2004 164659-663
12
The Patient with early stage CKD is 5 to 10 times
more likely to die from a cardiovascular event
than progress to ESRD.
  • Foley RN, Murray AM, Li S, Herzog CA, McBean AM,
    Eggers PW, Collins AJ. Chronic kidney disease and
    the risk for cardiovascular disease, renal
    replacement, and death in the United States
    Medicare population, 1998 to 1999. J Am Soc
    Nephrol 2005 16489-95.

13
So what do we do about this?
14
Chronic Kidney Disease
  • In 1999, the NKF approved a proposal for K/DOQI,
    Kidney Disease Outcomes Quality Initiative (an
    evolution of the DOQI (Dialysis Outcomes Quality
    Initiative).
  • The purpose was to develop clinical practice
    guidelines for the spectrum of kidney diseases.
  • In February 2002, Clinical Practice Guidelines
    for Chronic Kidney Disease (CKD) Evaluation,
    Classification, and Stratification were published.

Find the KDOQI guidelines at http//www.kidney.org
/professionals/KDOQI/
15
Guideline 1. Definition and Stages of Chronic
Kidney Disease
  • Adverse outcomes of CKD can often be prevented or
    delayed through early detection and treatment.
    Earlier stages of CKD can be detected through
    routine laboratory measurements.
  • The presence of CKD should be established, based
    on presence of kidney damage and level of kidney
    function (glomerular filtration rate GFR),
    irrespective of diagnosis.
  • Among patients with CKD, the stage of disease
    should be assigned based on the level of kidney
    function, irrespective of diagnosis, according to
    the K/DOQI CKD classification

16
Who should we screen?
17
How should we screen?
18
Serum Creatinine, CrCl, and eGFR--Nothing is
Perfect!
  • Serum Creatinine alone CAN NOT be used to
    accurately assess level of kidney function.
  • S. creatinine is a function of production (muscle
    mass) and excretion (both GFR and tubular
    secretion).
  • Age, sex, and lean body mass have to be taken
    into account.
  • Estimations of eGFR (MDRD equation) and CrCl
    (Cockcroft-Gault equation) were NOT developed in
    subjects with normal renal function or normal
    health.

19
Factors Affecting Serum Creatinine Concentration
Increase Decrease
  • Kidney Disease
  • Ketoacidosis
  • Ingestion of cooked meat
  • Drugs
  • Trimethoprim
  • Cimetidine
  • Flucytosine
  • Some cephalosporins
  • Reduced Muscle Mass
  • Malnutrition

20
Remember. GFR normally decreases with age!
21
Cockcroft-Gault Equation to Predict GFR
  • Developed to predict creatinine clearance, thus
    an overestimate of GFR
  • Prediction based on age, gender, creatinine and
    ideal body weight
  • ClCr (cc/min) 140-age x IBW/72 x SCr x 0.85
    if female
  • Used almost universally as the basis for drug
    dosing!

22
MDRD Equation to Predict GFR
  • Prediction based on age, gender, race and serum
    creatinine. Developed to follow GFR as part of
    the Modification of Diet in Renal Disease (MDRD)
    study. Validated.
  • GFR/1.73m2 186 x Pcr-1.154 x age-0.203 x
    0.742 if female x 1.212 if AfAm

Get it at http//www.kidney.org/professionals/KDOQ
I/gfr.cfm
23
TA-DA!(Your on-line link to the MDRD GFR
calculator)
http//www.kidney.org/professionals/KDOQI/gfr.cfm
24
Cockcroft-Gault vs. MDRD
  • The MDRD equation estimates GFR.
  • eGFR is given per 1.73m2 BSA
  • The Cockcroft-Gault equation estimates CrCl.
  • CrCl is best used for drug dosing decisions--drug
    dosing is usually indexed to CrCl.

25
Comparing the Cockcroft-Gault and MDRD Do these
patients have the same level of renal function?
  • 20 year old AfAm Washington Redskins tackle,
    weighing 144 kg with a SCr 1.2 mg/dl?

ClCr140-20144/72 x 1.2 200 cc/min
MDRD GFR Value99 mL/min/1.73 m2
  • 93 year old Caucasian female nursing home
    resident, weighing
  • 44 kg with a SCr 1.2 mg/dl.

ClCr 140-9344/72 x 1.2 x 0.85 20 cc/min
MDRD GFR Value45 mL/min/1.73 m2
26
Patient meets definition of Chronic Kidney
Disease?
YES NO
Risk Factor Reduction
Determine Stage of CKD Determine underlying
cause Identify risk factors for progression
Identify comorbidites
27
Tools for Determining the Cause of Chronic Kidney
Disease
  • CKD is often silent. Assessment relies on
    laboratory testing and imaging.
  • A Good History! ROS, existence of chronic
    diseases (DM, HTN, CHF, cirrhosis), medication
    review, accurate PMH and FH of kidney disease.
  • Helpful Physical Examination! BP, evidence of
    co-morbid conditions and complications of CKD.

28
A Simple Laboratory Evaluation!
29
Simplified Classification of CKD by Diagnosis
  • Diabetic Kidney Disease
  • Nondiabetic Kidney Disease
  • Glomerular disease
  • autoimmune, sytemic infections, drugs, neoplasia,
    idiopathic
  • Vascular disease
  • ischemic renal disease, hypertensive
    nephrosclerosis, microangiopathy
  • Tubulointerstitial disease
  • UTO, stones, UTI, drug toxicity
  • Cystic disease
  • Post-Transplant

30
Differential Diagnosis of Chronic Kidney Disease
  • Everyone deserves a diagnosis!
  • This is especially true for Stage 1 or 2 CKD!
  • When in doubt, consult a nephrologist!
  • Initial evaluation will guide further
    diagnostics, decisions about renal biopsy and
    often decisions about treatment and prognosis.

31
So Now What Do You Do? (Theres a lot you can
do!)
32
CKD Clinical Action Plan On-Line
http//www.kidney.org/professionals/kdoqi/cap/inde
x.html
33
Primary Goals of CKD Care
  • To prevent cardiovascular events and death
  • Heart Attacks
  • Congestive Heart Failure
  • Sudden Cardiac Death
  • Stroke
  • To prevent the progression of CKD to Kidney
    Failure or ESRD
  • To prevent complications of CKD
  • To prepare for dialysis/transplantation in a
    timely manner

34
Clinical Action Plan
  • A Clinical Action Plan should be developed for
    each patient, based on the stage of CKD (see
    Table 33).
  • Patients with CKD should be evaluated to
    determine
  • Diagnosis
  • Comorbid Conditions
  • Severity, assessed by level of kidney function
  • Complications, related to level of kidney
    function
  • Risk for loss of kidney function
  • Risk for cardiovascular disease
  • Review of medications should be performed at all
    visits.
  • Self-management behaviors should be incorporated
    into the treatment plan at all stages of chronic
    kidney disease.

35
Management of Patients with Chronic Kidney Disease
36
PROGRESSIVE RENAL DAMAGE The Final Common
Pathway
RENAL INJURY
Reduction in nephron mass
Glomerular capillary hypertension
Increased glomerular permeability to
macromolecules
Increased BP
Increased filtration of plasma proteins
Proteinuria
Excessive tubular protein reabsorption
Tubulointerstitial inflammation
RENAL SCARRING
37
Patient characteristics associated with increased
rate of GFR decline
Nonmodifiable Modifiable
  • African American race
  • Male gender
  • Older age
  • Lower baseline level of kidney function
  • Higher level of proteinuria
  • Higher BP
  • Poor glycemic control
  • Smoking

38
  • GUIDELINE 13. LOSS OF KIDNEY FUNCTION IN CKD
  • Interventions to slow the progression should be
    considered in all patients with CKD
  • Interventions proven to be effective include
  • Strict glucose control in diabetes
  • Strict blood pressure control
  • ACEI and ARBs
  • Interventions that may be effective, but studies
    are inconclusive, include
  • Dietary protein restriction
  • Lipid-lowering therapy
  • Partial correction of anemia.
  • Attempts should be made to prevent acute renal
    failure
  • Volume depletion
  • IV contrast
  • Some antibiotics (for example, aminoglycosides
    and amphotericin B)
  • NSAIDs, including COX 2 inhibitors
  • Other drugs ACEI, ARBs, calcineurin inhibitors
  • Obstruction.

39
Slowing Progression The Earlier, the Better
40
Interventions that delay progression of CKD ACEI
and ARBs
  • Mechanisms
  • Lower systemic blood pressure
  • Lower glomerular capillary blood pressure and
    protein filtration
  • Reduce AT II mediated cell proliferation and
    fibrosis

Should be employed in all proteinuric kidney
diseases!
41
Measuring ProteinuriaGet into the right spot!
When you get to this point, Dont continue to get
microalbumin!
42
PROGRESSIVE RENAL DAMAGE The Final Common
Pathway
RENAL INJURY
ACEI ARB
Reduction in nephron mass
Glomerular capillary hypertension
Increased glomerular permeability to
macromolecules
ACEI ARB
Increased BP
Increased filtration of plasma proteins
Proteinuria
Excessive tubular protein reabsorption
Tubulointerstitial inflammation
ACEI ARB
RENAL SCARRING
43
Interventions that delay progression of CKD ACEI
and ARBs
  • Diabetic Kidney Disease
  • ACEI or ARB in all diabetic patients with
    microalbuminuria
  • ACEI (alt ARB) for Type 1 Diabetics with
    macroalbuminuria
  • ARB (alt. ACEI) in Type 2 Diabetics with
    macroalbuminuria
  • Nondiabetic Kidney Disease
  • ACEI/ARB recommended in all proteinuric (gt200
    mg/g Cr on spot urine) patients with CKD
  • May tolerate creatinine rise of 35 above
    baseline
  • lt130/80 is goal
  • 3 or more drugs may be required! One will
    probably be a diuretic (thiazide first, then
    loop)
  • ACEI and ARB may be used in combination

-KDOQI Guideline 8, Table 110 -JNC 7, 2003
http//www.nhlbi.nih.gov/guidelines/hypertension/e
xpress.pdf
44
Controlling HypertensionGUIDELINE 7. ASSOCIATION
OF LEVEL OF GFR WITH HYPERTENSION
  • HTN is both a cause and a complication of CKD.
  • HTN may develop early during the course of CKD
    and is associated with adverse outcomesin
    particular, faster loss of kidney function and
    development of CVD.
  • Blood pressure should be closely monitored in all
    patients with chronic kidney disease.
  • Treatment of high blood pressure in CKD should
    include specification of target BP levels,
    nonpharmacologic therapy, and specific
    antihypertensive agents for the prevention of
    progression of kidney disease and development of
    cardiovascular disease.

45
Pathogenic Mechanisms of High Blood Pressure in
CKD
  • Pre-existing essential hypertension
  • Extracellular fluid volume expansion
  • Renin-agniotensin aldosterone system stimulation
  • Increased sympathetic activity
  • Alteration in endothelium-derived
    factors(NO/endothelin)
  • Increased body weight
  • Erythropoietin administration
  • PTH secretion/hypercalcemia
  • calcified arterial tree
  • renal vascular disease and renal artery stenosis

46
Relationship between BP and progression of
diabetic nephropathy. BP, albumin excretion
rate, and GFR in patients with type 1 DMs
randomly assigned to a reduction in MAP of 10 mm
Hg using metoprolol at 100 to 400 mg/d,
hydralazine at 50 to 200 mg/d, and furosemide at
80 to 500 mg/d versus no antihypertensive
therapy. Solid circles represent the treated
group. Open circles represent the control group.
Vertical lines represent standard error. Study
was stopped earlier in the control group because
of faster decline in GFR. Reprinted with
permission.253
Controls
Controls
Controls
Controls
GFR vs. Time
BP vs. Time
AER vs. Time
47
Relationship between MAP and GFR decline
(Non-diabetic Pts). Mean GFR decline and
achieved follow-up BP in MDRD Study A (patients
with baseline GFR 25 to 55 mL/min/1.73 m2).
Regression lines relating the estimated mean GFR
decline over 3 years to mean follow-up MAP for
groups of patients defined according to baseline
proteinuria. Within each group, a 3-slope model
was used with break points at 92 and 98 mm Hg.
Reprinted with permission.255
Nephrotic
48
JNC-7 recommends a goal blood pressure of lt130/80
mm Hg for individuals with high blood pressure
and CKD.
http//www.nhlbi.nih.gov/guidelines/hypertension/e
xpress.pdf
49
Recommendations for Controlling HTN in
Non-Diabetic CKD
Population BP Goal Nondrug Rx Drug RX CKD
gt200mg/g lt130/80 Reduce salt ACEI/ARB Prot/Cr
Ratio BMI25 kg/m2 Then diuretic Mod
EtOH Then BB or CCB Stop Smoking Exerci
se CKD no proteinuria lt130/80 Same Thiazide/
Loop Then ACEI/ARB Then BB or CCB
KDOQI Table 118, Guideline 9
50
Interventions that delay progression of CKD
Strict Glycemic Control
  • 80 Type I DM with microalbuminuria develop DN in
    10-15years, 50 to ESRD
  • DCCT, benefit of tight control in reducing
    occurrence subclinical and overt DN(40-60)
  • 20-40 Type II DM with microalbuminuria develop
    DN, 20 to ESRD
  • UKPDS 33, 25 reduction in microvascular events
  • Kumamoto
  • Steno Type 2, 73 reduction in clinical
    proteinuria

51
Interventions that delay progression of CKD
Strict Glycemic Control
  • Recommended Therapy
  • HgbA1c lt 7
  • Additional information in 2001 ADA Clinical
    Practice Guidelines
  • www.diabetes.org/clinicalrecommendations/Supplemen
    t101/S3.htm

52
Management of Patients with Chronic Kidney Disease
53
When to Expect Complications
54
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55
Anemia and CKD
  • Anemia usually develops during the course of
    chronic kidney disease and may be associated with
    adverse outcomes.
  • Anemia is one of the modifiable complications of
    CKD.
  • All individuals with hemoglobin (Hb) levels lower
    than physiologic norms are considered anemic.
  • Erythropoietin deficiency is the primary cause of
    anemia of CKD.
  • The NKF recommends that evaluation for anemia
    should occur when GFR lt60 mL/min/1.73 m2
    measurement should include Hb level.
  • Anemia should be treated according to the
    K/DOQITM guidelines for anemia of CKD.

56
K/DOQI Evaluation and Management of Anemia
  • For Adults with Stage 3 CKD
  • Assess Hemoglobin level
  • If anemia (HgB 12)
  • RBC indices/CBC
  • Reticulocyte count
  • Iron studies
  • Test for occult GI bleeding as indicated
  • Medical evaluation of comorbid conditions
  • Erythropoetin levels are usually NOT indicated.

57
Prevention of Uremic ComplicationsAnemia Therapy
  • Subcutaneous administration of erythropoietin
    once to thrice weekly (sometimes less).
  • Supplemental oral or IV iron to keep ferritin gt
    100 and iron saturation gt20.
  • Monthly monitoring of Hgb, iron stores.
  • Monthly adjustments in EPO dose and frequency to
    meet target Hgb 11-12 g/dl (HCT 33-36).

58
GUIDELINE 10. ASSOCIATION OF LEVEL OF GFR WITH
BONE DISEASE AND DISORDERS OF CALCIUM AND
PHOSPHORUS METABOLISM
  • Bone disease and disorders of calcium and
    phosphorus metabolism develop during the course
    of chronic kidney disease and are associated with
    adverse outcomes.
  • -Patients with GFR lt60 mL/min/1.73 m2 should be
    evaluated for bone disease and disorders of
    calcium and phosphorus metabolism.
  • -Patients with bone disease and disorders of bone
    metabolism should be evaluated and treatedsee
    K/DOQI Clinical Practice Guidelines on Bone
    Metabolism and Disease in Chronic Kidney Disease
    (October, 2004).

59
Prevention of Uremic ComplicationsOsteodystrophy
  • Osteitis fibrosis cystica, due to 2o HPT, is
    major form of bone disease.
  • Check indices of bone and mineral metabolism at
    GFR lt 60 cc/min/1.73m2
  • iPTH the earliest marker
  • Hypocalcemia, hyperphosphatemia
  • Phosphorus control is cornerstone of treatment

60
Prevention of Uremic ComplicationsOsteodystrophy
Therapy
  • Restrict dietary phosphorus to 800-1,000 mg/d
  • Calcium-based phosphate binders (but not with Vit
    D!) to combat hypocalcemia and bind phosphorus
  • Assure repletion of Vitamin D 25
  • Avoid acidosis, HCO3gt 23 mEq/l

61
Management of Renal Osteodystrophy is Very
Complex!
http//www.kidney.org/professionals/KDOQI/guidelin
es_bone/index.htm
62
GUIDELINE 9. ASSOCIATION OF LEVEL OF GFR WITH
NUTRITIONAL STATUS
  • Protein energy malnutrition develops during the
    course of chronic kidney disease and is
    associated with adverse outcomes. Low protein and
    calorie intake is an important cause of
    malnutrition in chronic kidney disease.
  • Patients with GFR lt60 mL/min/1.73 m2 should
    undergo assessment of dietary protein and energy
    intake and nutritional status
  • Guideline 23. Panels of Nutritional Measures for
    Nondialyzed Patients "For individuals with CRF
    (GFR lt20 mL/min) protein-energy nutritional
    status should be evaluated by serial measurements
    of a panel of markers including at least one
    value from each of the following clusters
  • (1) Serum albumin
  • (2) Edema-free actual body weight, percent
    standard (NHANES II) body weight, or subjective
    global assessment (SGA) and
  • (3) Normalized protein nitrogen appearance
    (nPNA) or dietary interviews and diaries.
    (Evidence and Opinion)"
  • Guideline 26. Intensive Nutritional Counseling
    for Chronic Renal Failure "The nutritional
    status of individuals with CRF should be
    monitored at regular intervals."

63
Prevention of Uremic ComplicationsMalnutrition
  • Contributors to protein-energy malnutrition(PEM)
    in CKD
  • low protein and calorie intake
  • metabolic acidosis
  • resistance to insulin, GH, IGF-1
  • proinflammatory cytokines
  • Assessment of nutritional status requires
    multiple markers to assess protein status, fat
    stores, body composition and dietary protein and
    energy intake.

64
Prevention of Uremic ComplicationsNutrition
Guidelines
  • Protein intake
  • 0.75g/kg/d (RDA)
  • GFR lt 25 cc/min(Stages 4-5) consider 0.6g/kg/d
  • Energy intake
  • RDA depends on energy expenditure
  • GFR lt 25 cc/min(Stages 4-5) 30-35kcal/kg/d
  • Patients with less than recommended intake need
    frequent follow-up of nutritional status

65
Prevention of Uremic ComplicationsJust a Word
About Immunizations
  • Dont forget to continue routine immunizations,
    e.g.
  • Tetanus
  • Pneumococcus
  • Influenza
  • Hepatitis B
  • Check for immunity first--ie, hepatitis B sAb,
    sAg, cAb
  • Those who are immune or have chronic infection do
    not need the vaccine.
  • All others should receive the vaccine. Dont
    wait for dialysis! Patients with advanced chronic
    kidney disease are less likely to gain immunity
    from the vaccine. Consider for all Stage 3 or
    greater CKD patients!

66
Management of Patients with Chronic Kidney Disease
67
GUIDELINE 15. ASSOCIATION OF CHRONIC KIDNEY
DISEASE WITH CARDIOVASCULAR DISEASE
  • Patients with CKD, irrespective of diagnosis, are
    at increased risk of cardiovascular disease
    (CVD), including coronary heart disease,
    cerebrovascular disease, peripheral vascular
    disease, and heart failure. Both traditional
    and chronic kidney disease related
    (nontraditional) CVD risk factors may contribute
    to this increased risk.
  • -All patients with CKD should be considered in
    the highest risk group for CVD, irrespective of
    levels of traditional CVD risk factors.-All
    patients with CKD should undergo assessment of
    CVD risk factors, including
  • Measurement of traditional CVD risk factors in
    all patients
  • Individual decision-making regarding measurement
    of selected CKD-related CVD risk factors in
    some patients.
  • -Recommendations for CVD risk factor reduction
    should take into account the highest-risk
    status of patients with chronic kidney disease.

68
The most common cause of death among ESRD
patients is CVD
Fig 5. Causes of death among period prevalent
patients 19971999, treated with hemodialysis,
peritoneal dialysis, or kidney transplantation.
Data are from the USRDS 2001 Annual Data Report
(www.usrds.org). Abbreviations MI, myocardial
infarction HD, heart disease.
69
Modification of ComorbidityCardiovascular
Disease
  • CVD is the cause of death in 40-50 ESRD patients
  • ESRD CVD mortality rates 15x higher than general
    population.
  • CVD is leading cause of death in patients with
    CKD, regardless of stage.
  • HDFP, pts with Crgt 1.7mg/dl, 58 deaths CV
  • British Regional Heart Study, 50 deaths CV in
    patients in upper decile of baseline Cr

70
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72
GFR and relative risk for CVD-related death.
Wannamethee625 risk is for SCr ? 1.5 mg vs
SCr ? 1.3 mg. Culleton622 risk is for SCr ? 1.5
mg and ? 1.4 mg vs. lt1.5 and lt1.4 in men and
women respectively. Upper limit for SCr was 3.0
mg. Mann637 risk is for SC ?  1.4 mg vs lt1.4
mg. Ruilope634 risk is for SCr gt1.5 mg vs ?
1.5 mg. Upper limit for SCr was 3.0 mg.
Fried640 risk is for SCr ? 1.5 mg versus SCr ?
0.9 mg. Hemmelgarn642 risk is for SCr gt2.3
mg/dL vs ? 2.3 mg/dL.
73
Proteinuria and relative risk for cardiovascular
disease. Where possible, results presented are
from multivariable analyses. Agewall650,
Ljungman647 Unadjusted results shown. Data not
available to calculate age or multivariable
adjusted risk.
74
Modification of ComorbidityCardiovascular
Disease
  • Patients with CKD should be considered highest
    risk for CVD.
  • Aggressive intervention and management of
    traditional CV risk factors is indicated.
  • This particularly includes dyslipidemias.
  • All adults with Stage1-5 CKD should be evaluated
    for dyslipidemia.
  • Fasting lipid profile with total cholesterol,
    LDL, HDL and triglycerides, at baseline, and at
    least annually.

75
Management of Dyslipidemia in CKD
http//www.kidney.org/professionals/KDOQI/guidelin
es_lipids/index.htm
Expert Panel on Detection Evaluation and
Treatment of High Blood Cholesterol in Adults.
Executive Summary of the Third Report of the
National Cholesterol Education Program (NCEP)
Expert Panel on Detection, Evaluation, and
Treatment of High Blood Cholesterol in Adults
(Adult Treatment Panel III). JAMA, 2001,
2852486-2497.
76
Management of Patients with Chronic Kidney Disease
77
When to Refer!
  • Consider co-management with a nephrologist if the
    clinical action plan cannot be carried out.
  • Consider subspecialty referral when
  • Unexplained proteinuria (gt1gm/day) or
    microalbumin/Cr ratio gt250mg albumin/gCr
  • Unexplained macroscopic or microscopic hematuria
  • Diabetes and macroalbuminuria
  • Multiple and recurring kidney stones
  • Rapidly deteriorating kidney function
  • Difficult to control hypertension
  • Refer to a nephrologist when GFR lt30 mL/min/1.73
    m2 (CKD Stages 4-5)!

Mandatory Referral to Nephrologist guideline,
Niagara Health Quality Coalition, NY
78
Fig 11. Level of GFR at initiation of replacement
therapy (USRDS). Data from Obrador et al.77
Diabetics
Medicare Eligible
Most should have started
79
Preparation for Renal Replacement Therapy(GFR lt
30cc/min/1.73m2)
  • Referral to a Nephrologist allows
  • Early identification of RRT modality.
  • Evaluation for kidney transplantation with goal
    of pre-emptive transplantation.
  • REMEMBER, in eligible patients transplantation
    confers a survival advantage over dialysis!
  • Identification of social, functional or
    nutritional needs.

80
Preparation for Renal Replacement Therapy(GFR lt
30cc/min/1.73m2)
  • Close coordination between PCM and nephrologist
    allows
  • Timely placement of dialysis access
  • Timely initiation of dialysis
  • Timely referral for transplant evaluation with
    preemptive transplant if possible.

81
Conclusions
  • CKD is a public health problem with poor outcomes
    and high cost. CKD is underdiagnosed and
    undertreated in the U.S.
  • Early CKD detection and intervention may increase
    opportunities for the prevention of ESRD and of
    complications of CKD, including death.
  • YOU, the PCM, CAN MAKE A Difference!
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