PRRS(???)

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??????????

• ?????(???)
• ??????
• ????????
• ???
• ?????????
• ???????
• ??
• PRRS(???)

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?????? Mycoplasma hyopneumoniae (M. hyo)
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• ????????????
• ??95???????100???
• ????????,???????

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• ????
• ?????(ADG) -??5??
• ?????(FCR)?? -??9??
• ??????
• ????
• PRDC ??????????
• ????????????

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• M. Hyopneumoniae ??????
• 0.2 0.5 µm small genome ??????
• No cell wall ????
• Pleomorph ???
• Sensitive in the environment ?????
• Resistant to antibiotics that interfere with the
  cell-wall synthesis (penicillins,
  cephalosporins)
• ????????????(?????????)????
• Difficult to cultivate expensive, time-consuming
• ??????????

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????

1. ??/??????????(????????????)
2. ???????????? ???????????
3. ?????????????(????)

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????????????????

• ???????,1014????????
• ???????(46?),??????
• ???????,??????????

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????????

• ?????????????
• ???26?,????,??????

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• Ciliated epithelium in the respiratory tract
  ??????????

Not infected ???
Infected with M.hyo ??M.hyo
10
????????

• ????????????????????
• ???????????????(APP?PM)???,????APP/PM???????
• ?????????????(????)

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??????????????????

• MH???PRRSV???????
• --??????????????
• --MH?????????????PRRS
• PRRS???????????
• PRRS??????????(??????)

????,38????????? ??PRRSV??,3 ????????
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• PRV?????????????
• ??????????MH?????????,?????????????

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????

• ????????(??????)??????
• 10???????--???????????
• ????????????3 km?
• ?????????????????????????

14
???
AIAO ???? Continous ???
? ?

• Example of infection pattern in a single site
  herd with either AIAO or continous production
  system ????????????????M.hyo ?????(Maes,2001)

15
?????

• ?????????????????
• ??
• ??????

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? ? ? ? ? ? ? ?
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??????????????????????????????,???????????
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? ?

• ???????????????????
• ??????
• ???IHA, CF, ELISA
• PCR?????
• ????????,???

32
???????
?????????
????
??????
?????????
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• ?????????
• AIAO
• MEW(medicated early weaning)
• SEW (segregated early weaning)

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?????????????
?? ????
?????? 10-13
???????? 20-28
?????(???) 9-14
???????(??) 8-10
????(??) 10
???? 11-16
???? 20
?? 14-20
PRRS(???) 9-16
??????(TGE) 20
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• ?????
• ????????????????? ??
• ????CTC/OTC

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• ????
• ???
• ????????

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• Vaccination ????
• ???????????????,????????M.hyo???
• ??????????????????????????,???????????????????

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• The most used MH vaccines in the US and EU
• ????????????????
• in the US RespiSure, Ingelvac, MPAC
• in EU Ingelvac, Stellamune

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3????????
?? ???? ???? ???? ???? ????? ????(week) ??????(hr)
RespiSure Stellamune 2 Oil-in-water 4 lt24
Ingelvac M.hyo 1 Water-in-oil - 2-3 500-900
MPAC 2 Oil-in-water 4 lt24