?? (Myoinositol) ? Phosphatidylinositol ? Diacylglycerol ? Inositolpolyphosphate - PowerPoint PPT Presentation

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?? (Myoinositol) ? Phosphatidylinositol ? Diacylglycerol ? Inositolpolyphosphate

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Title: ?? (Myoinositol) ? Phosphatidylinositol ? Diacylglycerol ? Inositolpolyphosphate


1
???????
  • ???
  • ????

2
??????????
  • ????????????

3
??????????????
  • ?? (Myoinositol) ?Phosphatidylinositol ?
    Diacylglycerol ?
    Inositolpolyphosphate

4
??????????????
  • ??????????? ? ?? ???????,???? ?
    ????????

5
??????????????
  • ?????
  • ????
  • ????
  • ????

6
??????????????
7
??????????????
  • ??????
  • ???????

8
??????????????
  • ??????
  • ???????
  • ????????(???????!)

9
??????????????
  • ??????
  • ???????
  • ????????
  • ??????????
  • ??????
  • ??????????,?????,????????????(?????Charcot joint)

10
Charcot Foot(????)
  • ????? (Rocker-Bottom Foot)

11
Charcot Foot(????)
12
(No Transcript)
13
Charcot Foot(????)
14
??????????????
  • ????????????????????
  • ?????????????????????????
  • ??????
  • ????????????????
  • ?????????????

15
?????
16
?????????????
17
?????????????
18
?????????????
19
??????
20
??????
  • ????????? (A/B)
  • 0.9-1.2 ??
  • lt0.9 ????
  • lt0.5 ?????
  • gt1.2 ???? ??

21
Fontaines Clinical Classification of Peripheral
Arterial Occlusive Diseases
Fontaines Classification
ABI Value
Cold sensation, numbness Intermittent
Claudication Pain at rest Ulcer,
necrosis (spontaneous gangrene)
0.9 0.7
Grade I Grade II Grade III Grade IV
0.7 0.4
0.4 0
0.2 0
??/???????????????????????(????), p39, ????,
2000(????)
22
Prevalence Rate with PAD - NIDDM patients with at
least 1 risk factors -
ABI Taiwan ( Population 690 ) Asia ( Population 6768 )
gt 0.9 81.9 83.2
? 0.9 0.7 13.0 ---
? 0.7 0.4 4.3 ---
? 0.4 0.2 0.1 ---
PAD lt 0.9 17.5 16.8
2004 Hong Kong PAD SEARCH Meeting
23
(No Transcript)
24
(No Transcript)
25
(No Transcript)
26
(No Transcript)
27
??????
28
??????Rydel-Seiffer?????
29
??????5.07,10??Semmes-Weinstein??????
  • ?????
  • 0????
  • 1????
  • 2????,??
  • 3??????
  • ????358???????,??32???42???,??2?3??(Rith-Najarian
    et al. D iabetes Care 1992 15 1386-9)

30
???
  • ???????
  • ????(chemotaxis)??
  • ?????????????????
  • ??????
  • GLUT4?

31
??????
  • ????????????,?????????(collagen)
  • ?????????????,?????
  • ???????,???????? (Yue et al. Diabetes 198736
    296-299)

32
Streptozotocin ???????????? (Yue et al. Diabetes
1987 36 296-299)
  • ????4?????
  • ???11?,2059 g,?? 945mg/dl,GHb
    9.53.6,????34.05.0N
  • ????9?,163 10 g,??54477,GHb 19.62.8,????
    13.74.3N

33
???????20??????? (Gottrup and Andersen, J Surg
Res 1981 31 61-68)
34
???????Wagner????
35
????
36
???? ?????
  • ????????(??? lanolin)
  • ???????????????
  • ??,?????
  • ????????
  • ??????????????????????
  • ??????????

37
???????
  • ???????????,??
  • ?????,??????????,????????

38
???????
  • ??????????????12?
  • ?????,?? total contact cast?????????
  • ??????
  • ????????

39
??????
  1. ??,???????

40
??????
41
??????
42
??????
43
???????????
44
?????
  • ??
  • ??????????,???
  • ?????????????

45
?????
  • ???????,??????????

46
?????
  • ????????,??????????

47
?????
  • ?????????????,????????
  • Betadine
  • ????
  • ???????
  • ?????,?????

48
?????
  • ????????,???????,?????????????

49
?????
  • ??????????????

50
?????
  • ???????????????
  • Comfeel
  • Tegasorb
  • Regranex
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