Hemostasis

1
Hemostasis

• platelet plug formation
• vasoconstriction
• blood coagulation

2
PlateletFormation
Fig. 18.20
Fig. 27-2 Ganong
3
Platelet Activation and Platelet PlugFormation
Fig. 18.21
4
CoagulationMechanisms
Fig. 18.23
5
Common Mechanism
Fig. 18.23
Fig. 18.22
6
Extrinsic Mechanism
Fig. 18.23
7
Intrinsic Mechanism
Fig. 18.23
8
CoagulationMechanisms
positive feedback
Figure 2724 Ganong. The clotting mechanism. a,
active form of clotting factor. TPL, tissue
thromboplastin TFI, tissue factor pathway
inhibitor. For other abbreviations, see Table
278.
9
Hemostasis Various Topics

• Clot retraction
• Clot dissolution
• plasmin /
• plasminogen activator
• Thrombus / Thrombotic Embolus
• Anticoagulants
• aspirin
• heparin
• oxalate/citrate/EDTA
• coumarins

Fig. 27-25, modified Ganong