Introduction to Bioengineering Presented to Chabot College ENGR10

1
Introduction to BioengineeringPresented to
Chabot College ENGR10 Nov06
Ovijit Chaudhuri PhD candidate Department of
Bioengineering, University of California Berkeley
2
What is Bioengineering?

• Applying engineering techniques/analysis and
  technology to biological and medical problems.
• Some areas (biomedical engineering) are focused
  on medical applications and using technology for
  solutions to healthcare problems (traditional).
• Others are focused on using engineering
  principles and ideas to understand the way
  biological systems are constructed.
• Bioengineering is very interdisciplinary
  encompassing various fields.

3
Prosthetics Hip replacement
4
Medical Imaging

• MRI, PET, CAT, etc

Cuellar Clinic website
5
Biomechanics

• How stiff does the hip replacement need to be?
• What kind of loads will it experience?

6
Biomaterials

• Mechanical properties?
• Materials that are easy to mold?
• What kind of materials are biocompatible?
• Wear, tear, corrosion.
• Immune Response?

www.machinedesign.com
7
Improving healthcare Lab on a chip Devices
El-Ali, et al., Nature, 2006
Yager, et al., Nature, 2006
Whitesides, Nature, 2006
8
Drug Delivery
Microjet injection device Fletcher lab, UC
Berkeley
Glucose sensor/ delivery device Gough lab, UCSD
9
Industry

• Hip replacement
• Other prosthetic devices
• Cardiac stents (Guidant, Johnson and Johnson)
• Other cardiac devices
• Drug delivery devices

10
Understanding the engineering of biological
systems - Computational Biology
Max Delbrueck Center Berlin-Buch
11
Understanding the engineering of biological
systems - Synthetic Biology
Keasling lab, UC Berkeley
12
Understanding the engineering of biological
systems -Tissue Engineering
Engler, et al., Cell, 2006
Kurpinski, et al., Cell, 2006
Nelson, et al., Science, 2006
13
Understanding the engineering of biological
systems cell mechanics and motility
David Rogers, Vanderbilt U.
14
Atomic Force Microscopy
15
Our Atomic Force Microscope
16
Growing actin networks power cell movement and
provide rigidity
Svitkina, et al.,JCB, 1999
17
Our studies of actin networks
Parekh, et al., Nat. Cell Bio. 2005
18
Questions?