High level of low density lipoprotein cholesterol in adult children of patients

1
High level of low density lipoprotein cholesterol
in adult children of patients with premature
coronary heart disease relation to own and
parental characteristics MV. Konnov, LM.
Dobordzhginidze, AD. Deev, NA. GratsianskyCenter
for Atherosclerosis, Institute Of
Physico-Chemical Medicine, Moscow, Russian
Federation
Table 1. Results of univariate analysis
Table 2. Results of multivariate analysis
Factors related (with plt0.1) to high LDL-C in adult children OR 95 CI P
LDL cholesterol of proband - parent, mmol/l 1.46 1.12 to 1.91 0.005
LDL cholesterol of consort - parent, mmol/l 1.83 1.17 to 2.86 0.008
metabolic syndrome of consort parent 2.66 1.22 to 5.81 0.014
BMI of consort - parent, kg/m2 1.10 1.02 to 1.18 0.015
own smoking 0.74 0.59 to 0.95 0.016
waist circumference of consort - parent, cm 1.04 1.01 to 1.08 0.017
own diastolic BP, mm Hg 1.03 1.00 to 1.06 0.054
own BMI, kg/m2 1.06 0.99 to 1.12 0.086
Independent predictors of high LDL-C in adult children OR 95 CI P
LDL cholesterol of proband - parent, mmol/l 1.46 1.12 to 1.91 0.005
LDL cholesterol of consort - parent, tertile 3 (4.42 mmol/l) vs tertile 1 (lt3.71 mmol/l) 5.18 1.72 to 15.6 0.003
BMI of consort - parent, tertile 3 (29.4 kg/m2) vs tertile 1 (lt25.5 kg/m2) 3.36 1.25 to 9.02 0.016
own smoking vs non-smoking 0.46 0.24 to 0.88 0.018
Conclusions

• In this group of adult children with parental
  premature CHD
• LDL-C level of proband-parent was independently
  associated with high LDL-C
• However characteristics of consort-parent (LDL-C
  and BMI) were also independently related to high
  LDL-C in their adult children.

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