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A Critical Role for AADR in Shaping the Future
of Academic Dental and Craniofacial Research
AADR PRESENTATION TO ADEA NEW DEANS
Rena DSouza, AADR President Christopher Fox,
AADR Executive Director
Nov 10th, 2012
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Topics

• How Dentistry Evolved
• - The Discoveries of Dentists that Shaped Health
  Care
• Challenges and Opportunities for Dentistry
• - Can we Shape the Future?
• Translational and Clinical Research
• - What ? Why ? How ?
• Signature Initiatives from NIDCR/NIH
• What is AADRs Role?

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The Beginnings. Barbers and Blacksmiths
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Past 150 yrs

• Horace Wells
• William Morton
• G.V. Black
• Edward Angle
• Truman Brophy
• Willoughby
• Miller (1890)
• -Bacterial basis for
• Oral Diseases
• -Disease Prevention

(JADA 140, 2009)
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The Scientific Evolution of Dentistry

• William J. Gies and the 1926 Carnegie Foundation
  Report on Dental Education
• Dental Schools Incorporated as part of Health
  Sciences/Medical Centers and Universities
• Development of Dental Scientific Journals and
  Publications in Medical and other Scientific
  Journals
• The role of immigrant dental scientists from
  Europe
• Opening of National Institute of Dental Research
  in 1948

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The Challenges are Great Too !!!
Those closest to the clinical challenges will
generate the most pertinent and relevant
questions. Hence a robust body of dental and
craniofacial research findings should be
emanating from our dental institutions
How to translate discoveries about the DOC
complex into better treatment and prevention of
diseases and disorders while pushing the
frontiers of basic science yet further ?
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Our Needs Are Great!!!!
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Challenges and Opportunities for Dentistry

• Research is becoming more difficult to support
• Grants are difficult to obtain
• Higher of NIDCR Funding outside dental schools
• New schools with minimal infrastructure for
  research
• Lack of formal training in clinical research
  methods
• Need for better diagnostics, point-of-care
  therapeutics
• Several studies available for translation
• Increase in evidence-based instruction

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Back to the Future..
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NIDCR, 2012
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Personalized MedicinePredictive, Preventive,
Precision Care

• Personalized medicine in the sense of the right
  treatment for the right patient at the right
  time-has been practiced for millennia (Steele,
  F. Pers. Med. 2009.6,1-5)
• Provides the ability to classify individuals into
  sub populations based on their susceptibility to
  a disease or response to a specific treatment

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NIDCR 2012
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NIDCR 2012
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• NCRR Supports the Continuum of Biomedical Research

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Definition of Translational Research

• Translational research fosters the
  multidirectional integration of basic research,
  patient-oriented research, and population-based
  research, with the long-term aim of improving the
  health of the public (Rubio et al., 2010)

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NIH definitions of clinical research

• Clinical Research. NIH defines human clinical
  research as
• (1) Patient-oriented research. Research conducted
  with human subjects (or on material of human
  origin) for which an investigator (or colleague)
  directly interacts with human subjects.
  Patient-oriented research includes
• (a) mechanisms of human disease,
• (b) therapeutic interventions,
• (c) clinical trials, and
• (d) development of new technologies.
• (2) Epidemiologic and behavioral studies.
• (3) Outcomes research and health services
  research.

NIDCR, 2012
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Clinical Research

• Traditional epidemiology studies
• Mechanistic studies using patient samples
• Other studies, such as cohort studies following
  subjects to determine outcomes of treatment(s).
  An example would be a study following individuals
  with diabetes and dental implants to determine if
  poor glucose control is associated with shorter
  implant survival.

NIDCR, 2012
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Educational and training opportunities

• NIH CTSA program
• Many translational training programs developed
  at CTSA institutions, many focused on training
  clinicians, but others focused on training basic
  scientists
• CTSA institutions working to develop common
  training standards and best practices--core
  competencies under development
• CTSA consortium creating a repository of
  programs (on-line and traditional) available at
  institutions around the countryNational CTSA
  Educational Resource Program

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2010-Building a National CTSA Consortium 55 CTSA
sites in 28 states and the District of Columbia
NJ
PR
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National Dental Practice- Based Research Network
NDPRN
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NIDCR, 2012
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NIDCR, 2012
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NIDCR 2012
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NIDCR, 2012
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NIDCR, 2012
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NIDCR, 2012
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How can AADR Help?

• Organize Information Transfer Sessions and
  Training Workshops at AADR Annual Sessions??
• Clinical Research Methodology ?
• Research Mentoring Teams for Junior Faculty?
• Practice-Based Research Network Forums ?
• Meetings with Program Officers from Funding
  Agencies ?
• Year-long AADR- Sponsored Activities ???
• Visits of President and Board Members to Schools
  ?
• Activation of Local Chapters/Sections?
• Dean Participation???

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IADR/AADR Global HQ, Alexandria, VA
Rena DSouza, AADR President, rdsouza_at_bcd.tamhsc.e
du Christopher Fox, AADR Executive Director,
cfox_at_iadr.org