Piama birth cohort

1
Piama birth cohort
Gerard H. Koppelman Pediatric Pulmonology and
Pediatric Allergology Beatrix Childrens
Hospital, University Medical Center Groningen,
the Netherlands
Groningen Research Institute for Asthma and COPD
2
Piama part of the Allergenic study

• A nation wide Dutch collaborative study on atopy
  development in three birth cohorts
• Piama
• Prevask
• KOALA

3
The ALLERGENIC study
PREVASC KOALA
PIAMA
Bottema et al, Eur Respir J 2008 32 593602
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ALLERGENIC
5
IgE in Allergenic
0
3 mnd
1 jr
4 jr
6 jr
8 jr
2 jr
PR
Spec IgE N 1206 Total IgE N1242
Spec IgE N1093 Total IgE N1093
Spec IgE N1732 Total IgE N1899
Spec IgE N212 Total IgE N212
Spec IgE N714 Total IgE N748
6
IL13 / 3UTR and serum IgE
Bottema et al, Eur Respir J 2008
7
PIAMA study

• 1)  general overview2)  what are the
  strengths3)  what resources do you have4)  what
  areas would you be interested in collaborating
  on?

8
PIAMA study - overview

• a placebo controlled intervention study in which
  the effect of mite impermeable mattress covers
  was studied
• a natural history study
• Recruitment took place in 1996-1997
• Total n 4,146

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Measurements in Piama
0
1 jr
4 jr
6 jr
8 jr
2 jr

• House visit
• Exposure
• LPS
• Der P1
• Eczema

Cord blood IgE

• Clinic visit
• Total IgE
• Sp IgE
• FEV1
• BHR
• NO

• Clinic visit
• Total IgE
• Sp IgE
• FEV1
• BHR
• NO

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PIAMA study - age 4

• All 1,327 children of allergic mothers
• a random sample of 663 children of non-allergic
  mothers
• Medical examination 1,288 children
• DNA was collected from 1,046 of these children

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PIAMA study strenghts

• Excellent follow up, now untill age 11
• Homogeneous Dutch population
• Potential to pool data with 2 other Dutch birth
  cohorts
• Environmental data LPS, Der P1 in subset
• Air pollution based on address information

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CD14 -550, dog and IgE
Dog
Age (years)
Bottema et al, Eur Respir J 2008 32 593602
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PIAMA study resources

• DNA is now available of over 2,000 children
• GWAS data in n 400 (GABRIEL)
• DNA genomic / amplified DNA
• Follow up investigations ongoing

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PIAMA study collaboration

• Field of interests
• Phenotype
• Bronchial hyperresponsiveness / lung function /
  NO
• Early wheezing phenotypes
• G x E
• Passive smoking, intervention study
• Air pollution
• Pooling of data LPS, Der P1
• Open towards collaborations

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Acknowledgement

• UMCG / University Groningen
• N.E. Reijmerink
• R.W.B Bottema
• D.S. Postma
• M. Kerkhof
• J. Gerritsen
• Erasmus MC Rotterdam
• J. de Jongste

• IRAS, Utrecht
• B. Brunekreef
• RIVM, Bilthoven
• H.A. Smit

• University Hospital / University Maastricht
• C.P. van Schayck
• F. Stelma
• C. Thijs