The Acute Phase Response

1
The Acute Phase Response

• Activated in response to alarm cytokinesIL-1,
  IL-6.
• Enhances host resistance, minimizes tissue
  injury, promotes resolution and repair of
  inflammatory lesion.

2
The Inflammatory Response

• Produced through(I) Ab Independence(a) Tissue
  Injury(b) Alternate complement pathway(II) Ab
  Dependence(a) Classical complement(b) Mast cell
  degranulation

3
Mediators of Inflammation
4
Mast Cell Mediators
5
Chemokines

• Function Stimulates chemokinesis and chemotaxis
  (a chemotactic cytokine.)
• Two types
• C-C (produced mainly by activated T cells - acts
  mainly on subsets of m/ps and TH cells). e.g.
  RANTES
• C-X-C (produced mainly by m/ps, endothelial
  cells, fibroblasts - acts mainly on neutrophils).
  e.g. IL-8

6
(No Transcript)
7
The Complement Pathway
8
Biological Functions of Complement
9
Biological Functions of Macrophages

• Phagocytosis
• Antigen-presenting cell
• Cytokine production

10
Innate vs Acquired Immunity
11
Innate-Adaptive Immunity
12
The Antiviral Response
13
Fc Receptors
14
Antiviral Immunity
15
TNF?
16
Delayed-Type Hypersensitivity I
17
T Cell Receptor
18
Mechanism of T Cell Triggering
19
Successful Effector Cell Stimulation Requires
Accessory Molecules
20
TH1 vs TH2
21
TH1 vs TH2