Mitochondrial function is essential for life. Increasing attention is paid to mitochondrial dysfunction as this is coupled to many metabolic and age-related diseases such as Cancer, Parkinson

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Interested in Mitochondrial DNA and
mitochondrial function?
Join the Mitogroup at Institute of Clinical
Biochemistry, University of Oslo, Rikshospitalet,
and Centre for Molecular Biology and Neuroscience
INTRODUCTION
Facilities
Mitochondrial function is essential for life.
Increasing attention is paid to mitochondrial
dysfunction as this is coupled to many metabolic
and age-related diseases such as Cancer,
Parkinsons and Alzheimers Disease. At the
institute of Clinical Biochemistry, we are
focusing on the impact of mitochondrial DNA
(mtDNA) on the mitochondrial function.
Accumulation of damages to this DNA increases
with ageing, and result in reduced bioenergetic
capacity. Different genetic and environmental
factors contribute to the speed at which the
mtDNA is erroded. These include oxidative stress,
reduced mtDNA maintenance and life-style-related
metabolism. In collaboration with the Dept.
Medical Biochemistry, we are investigating the
impact of mitochondrial dysfunction in metabolic
diseases.
We are located at Rikshospitalet, 3rd floor in
the B building. The laboratory houses
approximately 20 persons, including Students,
Technicians, PhD students and PostDocs The
research group is an associated member of the
Centre of Molecular Biology and Neuroscience on
of the Centres of Excellence in Oslo.
The Mitogroup members
Projects
Analysis of mitochondrial involvement in
Cockaynes Syndrome Regulation of mtDNA repair
and consequences for apoptosis Bioenergetic
regulation by mtDNA integrity Mitochondrial
dysfunction in Huntingtons Disease Proposed
project Mitochondrial dysfunction in
Hematochromatosis
Contact information Lars Eide, Institute of
Clinical Biochemistry, Rikshospitalet, UiO,
B1.3002 phone [phone],
lars.eide_at_medisin.uio.no