Geographical Distribution of DF and/or DHF

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Geographical Distribution of DF and/or DHF
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?? ??????????          ????2008/03/19 0433
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? ? ? (???)

• ?????(classic dengue)
• ??????(primary dengue)
• ?????(dengue hemorrhagic fever, DHF)
• ???????(dengue shock syndrome,DSS
• ??????(secondary dengue)
• ????3-10 ????
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• ???????RNA??,???45nm
• ?????(nucleocapsid)???????
• ?????????????(envelope)
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• ?????RNA(ssRNA),RNA??????
• ????????(core protein, C)?????RNA
• ?????(capsomer)????,????14kd
• ??????(membrane protein, M),????8Kd
• ???????????54Kd???????(E)
• ?E???????????????(epitope)?

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Flaviviridae ????? Flavivirus ????
Structure of mature virion
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? ? ? ? ?
???? dengue virus ?????(???) ???? DEN-1 ????
DEN-2 ???? DEN-3 ???? DEN-4 ??????????? ???????
????
?????40 nm
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I
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II
III
IV
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• ??????????,????? (common antigen)
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• ????????????,???????????????(immunocomplex)?????
  ?????(Type ? complex-mediated hypersensitivity),??
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• ???(Halstead)
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• ?,????Fc??(receptor)???
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Mosquitoes
Primate
Sylvate maintenance cycle for dengue virus
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Primate
Mosquitoes
Human
Maintenance cycle for dengue virus
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  ??,??1-2????????????????,?????????????????????
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Human
Mosquitoes
Urban transmission cycle of dengue virus
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• ?????????(viremia),?????????,??????????
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???????????

• ???? Aedes aegypti
• ???? Aedes albopictus
• (Ae. polynesiensis)
• (Ae. scutellaris)
• ???? ????????????
• ???? ????????1500???????

?????????????
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Vector mosquitoes
Africa Aedes (Dicermmyia)
Aedes (Stegomyia) Asia Aedes
(Finlaya) Aedes
(Stegomyia) Americas Aedes sp.
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Sylvate cycle ????????
High vertical transmission rate of dengue virus
in Aedes mediovittatus ( gt 95 vertical
transmission rate)
Reproductive tissues suitable
(Freier Rosen 1988)
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Urban cycle
Mosquitoes
Mosquitoes
?
Vector transmission cycle of dengue virus
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Vertical transmission Transstadial transmission
Venereal transmission
Urban transmission cycle of dengue virus
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(Khin Than 1983)
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(Rosen et al. 1983)
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1 1-3 1-2 1-4
2 4-7 3-5 5-9
3 8-17 6-9 10-19
4 18-28 10-14 20-24
5 29-37 15-20 35-49
6 38-49 21-27 50-74
7 50-59 28-31 75-99
8 60-76 32-40 100-199
9 77 41 200
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