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National Diabetes Research Group. Chin J Int Med 20:678,1981

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Title: National Diabetes Research Group. Chin J Int Med 20:678,1981


1
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2
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3
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National Diabetes Research Group. Chin J Int Med
20678,1981 Pan XR, et al. Diabetes 201664,
1997 Gu D, et al. Diabetologia 461190,
2003Wenying Yang, et al. N Engl J Med
20103621090-101.
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4
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?????(?????)
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??,????(???)
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  • Diabetes Statistics. October 1995 (updated 1997).
    NIDDK publication NIH 96-3926.
  • Harris MI. In Diabetes in America. 2nd ed.
    19951-13.

5
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?????????
1 ?????(?????????,????????) ?
1)????(??????????,??????????) ? 11.1mmol/l (200mg/dl)
2)????(???????8????????) ? 7.0mmol/l (126mg/dl)
3)75g??????2???? 11.1mmol/l (200mg/dl)
2 ???????,?????????????
1.??2????????.2007?. 2.Organization WH.
Definition, Diagnosis and Classification of
Diabetes Mellitus and its Complications. Report
of a WHO Consultation.WHO/NCD/NCS/99.2.
GenevaWHO,1999 1999.
6
??2???????????
??
HbA1c () lt6.5
???? (mmol/L) 4.4-6.1
????? (mmol/L) 4.4-8.0
??2????????.2007?.
7
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8
??2????????????
??70???2??????HbA1c???
27
73
Curr Med Res Opin. 2009 Jan25(1)39-45.
9
IMPROVE????????2???????????????
??? ????????? ?OAD?? ??? OAD (???????lt1??)
???? 21,729 7,012 12,890 1,769
?????? - 32.3 59.3 8.1
??HbA1c SD () 9.5 2.1 9.9 2.2 9.2 1.9 9.6 2.3
??1??????? 24.0 11.1 29.6 34.1
??1???? ??? 40.5 21.6 49.2 52.5
????????,HbA1c????
????????????
10
2009 ADA/EASD?????????????????

???? ?????HbA1c ???() ??
????????????
???????
?????? 1.0-2.0 ????
???? 1.0-2.0 ????????
?????????
??? 1.5-3.5 ??????,????,?????
??? 1.0-2.0 ????

Nathan DM. Diabetes Care 2009 32 193-203.
11
2007???2????????2?????????????
???????(BMI24kg/m2)
????? (BMIlt24kg/m2)
?????????? ????
?????????? ???????????????????????????????(????
)?a-??????
3???HbA1cgt6.5
????????????? ??????? ????????(????)? a-??????
3???HbA1cgt6.5
3???HbA1cgt6.5
?????
?????
??BMI 24kg/m2,??BMI 28kg/m2
??2????????.2007?.
12
DCCT/EDIC ???????????1????????????????
A
B
????????????????????????
????????????
Conventional treatment
P0.02
P0.02
??????42
??????57
Conventional treatment
Intensive treatment
Intensive treatment
Years since Entry
Years since Entry
  • DCCT/EDIC group. N Engl J Med. 2005 353(25)
    26432653.

13
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  • Holman RR et al. N Engl J Med 20083591577-1589.
  • UKPDS Study Group. Lancet, 1998

14
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15
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16
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19
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20
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Peacock I.et al? The Lancet, January 1983 149-152
21
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24
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25
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26
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27
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28
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(?) 27????????????????
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1.2008 IMS Data. 2.Internal Sales Data, 2008
29
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30
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31
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32
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33
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34
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35
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36
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37
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38
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39
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41
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P Kurtzhals P, et al. Diabetes 2000 49 999-1005
42
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43
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44
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Polonsky KS et al. N Engl J Med 1996334777
45
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46
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47
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48
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49
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51
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52
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53
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54
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55
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56
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57
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58
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59
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60
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61
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62
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63
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64
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65
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66
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67
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68
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69
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70
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Agency for the Evaluation of Medicinal
Products,???????)????
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71
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2007?????????
72
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74
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75
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76
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77
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78
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?? ??? 32G 6mm ??? 32G 6mm ??? 30G 8mm ??? 30G 8mm
??/????(BMIgt18kg/m2) 45???? ????? ???? ??
??-???? 90???? ????? ???? ??
??-??(BMIgt27kg/m2) 90???? 1. ????????? 2. ??????,?????? 90???? ????? ????
79
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80
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81
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82
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83
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