Therapeutic Peptides for Cardiovascular Disease and Cancer

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Therapeutic Peptides forCardiovascular Disease
and Cancer

• Cam Patterson, MD, MBA, FACC, FAHA
• Ernest and Hazel Craige Distinguished Professor
• of Cardiovascular Medicine
• Chief, Division of Cardiology
• Director, Carolina Cardiovascular Biology Center
• University of North Carolina at Chapel Hill

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Endothelial Progenitor Cells (EPC)from Biology
to Treatment

• ? In 1997, EPC were first identified in adult
  human peripheral blood
• ? EPC are immature cells capable of
  differentiating into mature endothelial cells
• ? EPC can play an important role in the formation
  of new blood vessels
• - mobilization from the bone marrow
• - migration through the
  circulation
• - incorporation into blood
  vessels
• ? Clinically, the number and function of EPC have
  been positively linked with improved endothelial
  function and regeneration

Rosenzweig A., NEJM, 348, 581 (2003).
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Phage Display Technology to Identify
PeptidesSpecific for Endothelial Progenitor Cells
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Peptides Immobilized on a Biomaterial Scaffold to
Improve Cyto- and Blood- compatibility of Implants
Veleva A. et al., Biomaterials, 29, 3656 (2008).
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New Functional Tools to Target Tumor Vasculature

• ? Tumor angiogenesis has a critical role in
  promoting the growth of most carcinomas
• ? EPC play an important role in
  angiogenesis-mediated tumor progression

? To utilize endogenous EPC as natural vectors to
deliver diagnostic and therapeutic reagents to
tumors
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Market Potential

• ? Regenerative Medicine
• - cell separations
• - production of pure cell populations for
  allogeneic stem cell therapies

? Medical Implant Technologies to treat
cardiovascular diseases, off-the-shelf
products - innovative intravascular stent
systems - small diameter vascular grafts -
pacemakers - heart valve repair - arterial
septal repair implants
? Oncology - targeting of tumor-associated
blood vessels - non-invasive detection of
small cancer tissue, primary tumors
metastases - targeted therapeutics, development
of highly specific drug delivery systems -
personalized medicine, monitoring efficacy of
therapies