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Title:

Transplantation

Description:

CTLA-4 gene B7-CD28 CD40-CD40L microchimerism * * Title: PowerPoint Author: Billgates – PowerPoint PPT presentation

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Title: Transplantation


1
?????
????????????
????? ????
  • ????
  • Transplantation
  • ?? ????
  • ???????
  • ??????
  • ????

Back
2
?????
????????????
3
?????
????????????
3. ???????? ???? no
rejection ??????? ?????? rejection ????
???? ???
4
?????
????????????
5
?????
????????????
6
?????
????????????
  • ????????(HVGR) HVGD
  • ????????(GVHR) GVHD
  • ?? donor
  • ?? recipient

7
?????
????????????
?????????? ??????????????? ??HVGR?GVHR
8
?????
????????????
  • ?????????MHC??
  • ????
  • ??????
  • ?????????

9
?????
????????????
  • ?????????(mHS)
  • ????(ABO??)
  • ??H-Y??
  • ???

10
?????
????????????
11
?????
????????????
  • ???????????????
  • ???T?????????(MHC??)??
  • ???????HVGR
  • GVHR

12
?????
????????????
13
?????
????????????
14
?????
????????????
??????(??)
15
?????
????????????
  • ????(direct recognition)
  • ??T???????(??APC)???MHC??
  • ??MHC????(??)????

T
TCR
??
????Tc ??????????? ????????????
16
?????
????????????
17
?????
????????????
2. ????(indirect recognition)
??T?????APC???MHC??? ???MHC??(??)
MHC MHC
T
APC
TCR
??
??
????CD4 Th ??????
18
?????
????????????
19
?????
????????????
20
?????
????????????
21
?????
????????????
  • ????????????????
  • ????
  • ???-??????
  • ??
  • ??Ab?????????(?????)

22
?????
????????????
  • ????
  • 1?3?????
  • ??
  • Th1?Tc??????
  • B????????
  • AgAb???????
  • ??Th1

23
?????
????????????
  • ????
  • 3???-??(??????)
  • ??
  • Th1?Mf???

24
?????
????????????
25
?????
????????????
  • ??????
  • ?????????,???GVHR,
  • ????????

26
?????
????????????
  • ??????
  • ?????????
  • ?????????
  • (??????,????????)
  • ??(??)?????
  • ???????????

27
?????
????????????
????????????? 1. HLA??
28
?????
????????????
????????(MLR)
29
?????
????????????
30
?????
????????????
  • 3. ??????
  • CTLA-4?gene
  • ??B7-CD28
  • CD40-CD40L
  • ??????(microchimerism)
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