III%20????,%20II%20????? - PowerPoint PPT Presentation

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III%20????,%20II%20?????

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Title: III%20????,%20II%20?????


1
?????????? ????????????. ??????????????? ?
??????????
?????????? ???????? ??? ?? ????? ??????? ??
???????????? ? ????????????
  • ???? ?????????
  • III ????, II ?????
  • ????? ? 2012

2
???????????
  • ?????????????? ?? ?????????, ????? ?? ????????
    ??? ???????? ???????????? ?????? ??????????.
    ?????????????? ?? ????????? ?? ???????????
    ???????????, ????? ?? ????????? ?????
    ?????????? ?????? ???????? ??????????? ??????
    ??? ??????? ????, ???????? ? ???????? ??????????
    ????????? ??? ???????? ????????.

3
??????????
4
????????????
5
???????????????
6
Clozapine (Leponex)
  • ?????????? ? ?????????????????? ??????????
  • ??????? ?? ? D1, D2, D3, D4, D5,
  • 5-HT1a/1c, 5-HT2a/2c, 5-HT3, 5-HT6,
  • a1 , a2 ???????????? ?????????,
  • ?1 ?????????

7
???????????????
  • ?????????? ?? ??????? ??????
  • ?????????? ?? ???????????? ?? CYP1A2 ??
    ???????????.

8
???
  • ??????????????
  • ???????
  • ???????? ? ????????? ?????????
  • ???
  • ?????????????
  • ??????????? ?? ?????? ??????????

9
Olanzapine (Zyprexa, Lazapix)
10
???????????????
11
???????????????
  • ??????????? ?? ??????? ?????????
  • ??????????? ?? ???????????? ?? CYP1A2 ? CYP2D6

12
???
  • ???
  • ??????? ? ????????
  • ????????? ?? ????????????? ????????????
  • ?????????? ?? QT ?????????

13
Risperidone (Rispolept)
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