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Vaclav Kirsner, PhD, Founder CEO

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Title: Vaclav Kirsner, PhD, Founder CEO


1
Transforming Female Reproductive Health Management
  • Vaclav Kirsner, PhD, Founder CEO
  • bioZhena Corporation
  • http//www.biozhena.com/
  • vaclav_at_biozhena.com
  • (970) 484-1272

Auguste Rodin, The Kiss
Profits from the already FDA-cleared application
of the Ovulona will support the introduction of
the next applications
2
Prolog THIS SLIDE IS WITHOUT MY VOICE WITHOUT
AUTO-ADVANCE. CLICK TO ADVANCE OR USE NAVIGATION
BUTTONS (BOTTOM LEFT) Broad electrometric
applicability of the Ovulona There is solid
precedent for observing differences between
electrometric signatures of normal healthy
cervical tissues (epithelia) and those of
aberrant tissues (e.g. pre-cancerous CIN
epithelia) as significant as those obtained from
analyzing Pap smear tests. The differences are
due to changes in the external and internal
structure of the cervical tissue cells. The same
holds for other physiological changes in the
tissues - including folliculogenesis and
pregnancy. Note these key words in the titles of
randomly selected 3 publications 1. impedance of
the cervix in non-pregnant and pregnant women 2.
cervical impedance in the prediction of the
course and outcome of labor 3. uterine and
cervical electromyography in monitoring pregnant
patients Conclusion of publication 3 The
potential benefits include a reduction in the
rate of preterm birth, improved maternal and
perinatal outcome, better monitoring of
treatment
3
What does Ovulona do?
It tracks folliculogenesis in vivo
(FIV)
Folliculogenesis is central to womens health,
well-being, and lifestyle.
Ovulona Personal Fertility Smart
Sensor Photo of a rapid prototyping model Note
This is not a real prototype. Real details are
not shown. The planned internally worn telemetric
cervical ring is not shown either.
4
What Is Folliculogenesis?
The biological foundation of a womans well-being.
5
Detecting the 3-day fertile window for getting
pregnant
What FIV does for women and for family planning
6
Different peak sizes show the different speed of
maturation of the egg in different menstrual
cycles (maturation of dominant follicle)
Unprecedented wealth of information inherent in
the signature FIV cyclic profile
These are follicular waves preparing for the next
cycle. They relate to how fast the woman
approaches menopause. They disappear upon
conception.
Ovulation is
detected as estrogen dominance switches to
progesterone dominance
This is the ovarian I am ready signal
7
Technology Overview
  • Disruptive technology
  • FOLLICULOGENESIS IN VIVO
  • Designed to improve quality and reduce costs of
  • womens reproductive and general health -
    from
  • adolescence to menopause
  • - Help women to conceive
  • - Help plan babys gender
  • Built-in detection of pregnancy and
  • Early Pregnancy Loss
  • - Forecast Expected Date of Delivery
  • - Help with natural birth control
  • - Help manage other conditions such as
  • menstrual cramps
  • PMS
  • menopause
  • screen for cervical cancer, STDs

8
Transformational Technology
MOSTLY GIRLS BORN 69
MOSTLY BOYS BORN 77
  • Unprecedented accuracy
  • Clear diagnostic indications no guessing
  • Easy to use
  • Automatically detects monitors pregnancy,
    computes Expected Delivery Date
  • Automatically screens for cervical cancer, STDs
  • Requires no chemical work, no graphing, no
    interpretation of data by the user
  • Provides folliculogenesis profile history data to
    healthcare system

9
Absence of the peaks anticipates failure to
ovulate. Ovulona anticipates LPD Luteal Phase
Defect, which often causes failure to conceive by
healthy women
Ovulonas diagnostic power will save healthcare
costs
  • This
  • cannot be matched
  • by ovulation kits
  • or by any other
  • such product

10
Ovulation prediction products
11
Comparison of technologies in the
trying-to-conceive self-help market This is
Ovulona monitors first application, FDA-ready
for market
Characteristics Ovulona BBT Thermo meters LH kits urine chemistry Saliva magnifying glasses Body fluid Conductivity
Accuracy High Low Low Low Low
Reliability High Low Low Low Low
Immediacy of results Yes Yes No Yes No
Convenience of use Yes No No Yes No
Low cost of ownership Yes Yes No Yes Yes
Information content High Low Low Low Low
Can be used for birth control? Yes No No No No
Can be used to preselect babys sex? Yes No No No No
Can it do built-in pregnancy check? Yes No No No No
Can it compute date of delivery? Yes No No No No
Folliculogenesis profile for healthcare? Yes No No No No
Multi-purpose long-term use? Yes No No No No
The Ovulona provides the most value, the
most quality per dollar spent
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