Insulin Therapy for Alzheimer

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Insulin Therapy for Alzheimers Disease
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It all began in 1983

• A group in Sweden noticed that there were
  differenced in blood glucose and insulin levels
  in patients with AD.
• Bucht 1983 Changes in Blood Glucose and Insulin
  Secretion in Patients with Senile Dementia of
  Alzheimer Type

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Alzheimers and Diabetes

• LSUHSCS Librarys OVID database searched
• Alzheimers cross-referenced with Diabetes
• Found 486 articles
• Over 300 evaluated
• 231 reports retrieved and reviewed

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And Every Year We Learn More
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Why Would Anyone Want to Treat Alzheimers With
Insulin??

• Because Alzheimers disease (AD) and Diabetes
  have the same underlying cause.
• AD is now being called Type 3 Diabetes

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Alzheimers ? ? Diabetes

• Hoyer 1998
• Is Sporadic Alzheimer Disease the Brain Type of
  Non-Insulin Dependent Diabetes Mellitus? (yes)
• Steen 2005
• Impaired InsulinExpression and Signaling
  Mechanisms in Alzheimers Disease is this Type
  3 Diabetes? (yes)
• De La Monte 2006
• Therapeutic Rescue of Neurodegeneration in
  Experimental Type 3 Diabetes Relevance to
  Alzheimers disease
• Kroner 2009
• The Relationship Between Alzheimers Disease and
  Diabetes Type 3 Diabetes? (yes)

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OK, So Why Isnt Insulin Already Being Used to
Treat AD?

• It is!
• Diabetic medicines, subcutaneous insulin,
  intravenous (IV) insulin, and even intranasal
  insulin have all been used.

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IV Insulin Therapy (non-pulsatile)(Suzanne
Crafts Laboratory - U. Washington, Seattle) 

• 1993 Effects of Hyperglycemia on Memory in AD
• 1996 Memory Improvement Following Induced
  Hyperinsulinemia in AD
• 1999 Enhancement of Memory in AD With Insulin
• 2000 Insulin Effects on Glucose Metabolism,
  Memory, and Plasma Amyloid Precursor Protein in
  AD
• 2003 Insulin doseresponse effects on memory and
  plasma amyloid precursor protein in AD
• 2004 Modulation of memory by insulin and glucose
  in AD
• 2006 Modulation of plasma ß-amyloid by Insulin in
  Patients With AD

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Intranasal Insulin Therapy (Suzanne Crafts
Laboratory - U. Washington, Seattle)

• 2004 (Germany) Intranasal insulin improves memory
  in humans
• 2006 Effects of intranasal insulin on cognition
  in memory-impaired older adults Modulation by
  APOE genotype
• 2008 Intranasal insulin improves cognition and
  modulates ß-amyloid in early AD
• 2008 Intranasal Insulin Modulates Verbal Memory
  and Plasma Amyloid-ß in Memory-Impaired Older
  Adults
• 2010 Clinical Trial of Intranasal Insulin Shows
  Some Benefits in Alzheimer's and MCI

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So Why Do Pulsatile IV Insulin for AD?

• Because non-pulsatile IV and intranasal insulin
  therapy
• Are disease modifying agents, yes
• Slow progression of AD, yes
• Even improve AD in some cases, yes
• BUT DO NOT address the underlying metabolic
  dysfunction.

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Pulsatile IV Insulin Therapy is Distinctly
Different

• This is an absolutely critical distinction to
  make
• Pulsatile IV insulin is a different drug than
  insulin delivered any other way, even
  non-pulsatile IV insulin!
• It addresses the underlying metabolic dysfunction
  ? decision made to call it Cellular Activation
  Therapy

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Pulses of insulin were discovered to be the
normal mode of pancreatic insulin delivery to the
liver

• Insulin is secreted from beta cells in the
  pancreas almost exclusively in pulses.
• The results of the study show that very large
  pulses of insulin go into the portal vein and
  then directly into the liver
• Prior to this study, no one had shown this effect
  in human beings
• Insulin release in the human portal vein occurs
  at a mean periodicity of 4.4 0.2 min with a
  high signal-to-noise ratio (pulse amplitude 660
  of basal).
• Peter Butler and Soon Song received the Endocrine
  Society's first prize for best clinical paper
  published in The Journal of Clinical
  Endocrinology and Metabolism in the year 2002.
• Butler, et al Direct Measurement of Pulsatile
  Insulin Secretion from the Portal Vein in Human
  Subjects, Am J Physiol Endocrinol Metab 2002
  Mar282(3)E695-E702

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Diabetics Metabolism Returns to Normal
CAT changes diabetics from unable to metabolize
glucose, to able to burn, store and release
glucose, thereby reducing the high levels of
lipid oxidation.
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Cellular Activation Therapy (CAT) Bionica
MicroDose Pump Mimics the Pancreas

• Provides what a healthy persons pancreas
  provides to a non-diabetic liver, pulses of
  insulin in the presence of glucose.
• Proven safe and effective way to reawaken the
  liver to provide the enzymes for proper
  metabolism
• The Bionica MicroDose FDA approved delivery
  system is unique and has been in continuous use
  for almost 20 years
• In over 100,000 treatments there has never been
  an adverse reaction, and never been a pump
  failure or injury
• This is because the treatment provides the
  stimulation that a normal body needs and
  receives.

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• The Bionica pump delivers extremely precise
  pulses of insulin at pressure.
• This special delivery is required to stimulate
  the liver and reawaken dormant metabolism.
• The unique Bionica pump is the only FDA CE pump
  labeled (authorized) for IV Pulsed Insulin.

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What to Expect During Treatment
One 6 hour treatment per week starting in the
early morning. The Bionica Pump delivers the
pulses tailored to mimic a normal
pancreas. Special software ensures proper
treatment and tracks results. Patients see
their metabolismrestored to normal healthy
levels. I would have been dead 3 years ago
without CAT. My doctor gave me six months.
(E. Iaconis)
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Now We Know

• Alzheimers (AD) and Diabetes Mellitus (DM) are
  essentially the same disease, in different organs
• Standard Insulin therapy helps with DM, but there
  are still problems
• Pulsatile IV Insulin ? Cellular Activation
  Therapy ? greatly improves DM
• IV or inhaled insulin helps AD, but there are
  still problems
• Cellular Activation Therapy for ADis what we
  need to do next!