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A Three-dimensional

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membrane of cells lining the small ... 20 mM GLUT2 Km ~ 5 mM GLUT4 Glucose regulation of insulin secretion by pancreatic cells Regulation by insulin of ... – PowerPoint PPT presentation

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Title: A Three-dimensional


1
Glucose transporter proteins
The Journal of Biological Chemistry, 2001, 276,
44970-44975.
A Three-dimensional Model of Glut1
SGLT -- the Na-dependent glucose co-transporters
-- glucose transport takes place across the
lumenal

membrane of cells lining the small intestine
and the

proximal tubules of the kidneys GLUT family
-- the facilitative Na-independent sugar
transporters
2
Model of glucose transport into erythrocytes by
GLUT1.
3
Wood IS, Trayhurn P. Br J Nutr. 2003 Jan89(1)3-9
Km 15 20 mM
GLUT2
Km 5 mM
GLUT4
normal serum-glucose level
4-8 mM
Km 1 mM
GLUT1 and GLUT3
4
Glucose regulation of insulin secretion by
pancreatic ß cells
5
Regulation by insulin of glucose transport by
GLUT4 into a myocyte
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