???????? Solid dispersions and pills

1
???????? Solid dispersions and pills
2
?????????

• 1. ??
• ?????(solid dispersions)??????????????????????
  ?????

?????
????
?????
??
?????
????????
?????
?????
3
?????????

• 1961?Sekiguch???????
• 1963?Levy?????????????
• ?????????????????????
• ???????????????????????,??????????????

4
?????????

• ????????
• ???????????????
• ?????????????
• ??????
• ?????
• ????????????,??????????????,?????????

5
?????? Carrier materials

• ???????????
• ???????
• ??????????
• ???????????
• ???????????????
• ????????????????????

6
?????? Carrier materials

• ??????
• ???
• ??? ???
• ???
• ???????????,?????????????????

7
?????? Carrier materials

(?)???????
??????
?????
??
???
??????
8
?????? Carrier materials

(?)??????? 1.???? 2.??????? 3. ??? ???
ß-??? ????
9
??????????

• ???3???
• 1. ????????
• ????????????,?????,???????????????,??????????????
• ????????????????????????,?????????????

10
??????????

2. ???? ????????????????,??????
?????????? (1)?????PEG 6000????????????
(2)?PEG6000????????PEG a-????
(3)??????PEG6000?????? ß-????
(4)????????42??? ????????
11
??????????

• (?)????
• ????(????)????????????????,?????????,?????????,???
  ????????????????
• ????? ?? PVP
• ??????(AD)?PVP?18??????,AD????PVP????????,??????
  PVP???????????????

12
????????????

???????6 ? ??????????,?????
(1)????? (2)?????????????
(3)??????
13
????????????

• 1.???
• ??????????,?????,?????????????,????????????????,??
  ????????????
• ????????,?????????????

14
????????????
?????? ???????,??????????,??????????????????????
??? ?? PEG???????? ???????????????,?????????
?????? ???????????????????,????
????????????????????

15
????????????

2.??? ????????????????????????,??????????????????
?,????????????????????,????? ??????????????????
????? PVP???????????? ??????,???????????????
16
????????????

3.????? ???????????,??????????????????????,??????
??? ?????????????10(w/w),????????????? ?????????
???????A?D?E,?????????50mg??? ?????,????,???
17
????????????

4.????(??)??? ??????????????,?????????,??????
? ????C1C4?????????? ??????????????????
????PVP??PEG??ß????????????????????????????
18
????????????

5.??? ????????????????,???????????,???????????
???????,???????????????,??????? ??????????? ????
?????????PVP??PEG?
19
???????????????

(?)???? 1.????????? ?????????????????????????
20
???????????????

(?)???? 2.?????????????? (1)
?????????????? (2) ??????????????
(3) ????????????
21
????????????
???????? ???????????,??????????? ????
??????? X????? ???????????,????????? ?????
??????????????,???????? ?????? ?????

22
??????????

• ?? pills
• ???????????????????,???????????,??????????????????
  ??????????
• ??
• ?????????????,?????
• ????????,??????????
• ???????,????????
• ???????????????
• ?????????????-???

23
???

1. ??????????
2. ??????????
3. ?????????????
4. ????????????