Euploidy

1
(No Transcript)
2
???????????????????
?????/?? ???????????????????? ???? triploid (3n)
, tetraploid (4n)

• Euploidy

3
Aneuploidy
Trisomy 21
Down syndrome 1/700-800 ??
?????? ??????????????? 21 ??????
????? ?????????????? , ????????????????????
??????? ??????????? ??????? ??????????
??????? I.Q. ?????? 25-49 ????????? 75
Mongolism
?.?. ???????
??????? 32 ???????????????? trisomy 21
?????????????? 19 ??? 3 ????
4
?????????????? ???????????? ???????
??????????? ??????? ?????????? ??????? I.Q.
?????? 25-49 ????????? 75
chromosome 21
5
Aneuploidy
Klinefelter syndrome
?????? ???????????????? X ?????? (2n
47) autosome 44 sex chromosome XXY
????? ?????????????????????? ????????
??????????? ???????? ????????
????????????????????? ??????????????????
?????????????
6
?????????????????????? ???????? ???????????
???????? ???????? ?????????????????????
?????????????????? ?????????????
7
Aneuploidy
Turner syndrome
?????? ????????????????? X ????? 1 ???? (2n 45)
monosomy X autosome 44 sex chromosome X
????? ??????????????????????? ???????????
????????? ?????? ????????? ????????
8
??????????????????????? ??????????? ?????????
?????? ????????? ????????
9
(No Transcript)
10
???????????????????

• Aneuploidy

?????/?? ????????????????????

• monosomy (2n - 1)
• trisomy (2n 1)
• tetrasomic (2n 2)

11
Euploidy
Triploid(3n)
???????? 17 ??????????????
?????? 80 ????????????????????? 2 ??? ????
polar bodies ??????????????????
????? ?????????????????? ?????????????????
???????????????? ?????????????????? ?????????? 2
?????
12
(No Transcript)
13
Euploidy
Tetraploid(4n)
?????????????? ?????????

• ???????????????????????? ???? polyploid ????
• ???
• bronchial epithelium
• amniotic membrane ??????????????