Avastin 100mg - Anticancer drugs | view uses, side effects and price | MHP

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AVASTIN 100mg
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DESCRIPTION

•  Bevacizumab is a drug sold under the name
  of Avastin 100mg and which is categorized as
  monoclonal anti-body anti-angiogenesis
• When Avastin concomitant use with human
  monoclonal antibody IgG1, that circumstance and
  prohibits the biological action of human vascular
  endothelial growth factor (VEGF)

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Usage

• Avastin is indicated for the treatment of some
  of the conditions like Metastatic colon or rectal
  cancer Non-squamous, non-small cell lung cancer
  Glioblastoma Metastatic renal cell cancer
  Metastatic cervical cancer Epithelial ovarian,
  fallopian tube or peritoneal cancer

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Mechanism of Action

•  Avastin 100mg comprises an active compound like
  Bevacizumab which binds to VEGF and avoid the
  communication of VEGF to its receptors like Flt-1
  KDR) present on the surface of the cells This
  interaction prevents endothelial cell
  multiplication and new blood vessel production
  occurs Hence in counts cessation of metastatic
  cancer cells development happens

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Avastin 100mg

• Brand Avastin
• Ingredients Bevacizumab
• Strength 400mg/16ml 100mg/4ml
• Manufactured Roche
• Package 400mg of Bevacizumab containing vial

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ADME PROPERTIES

• Distribution
• The volume of distribution is 2.9 (22) L

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Elimination

• The Bevacizumab half life period is 20days (11
  to 50days)

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Dosage Management

• Avoid administration of Avastin 100mg Injection 
  before at least 28 days following surgery and the
  wound is completely curedMETASTATIC COLORECTAL
  CARCINOMA
•  Concomitant use with 5-fluorouracil based
  chemotherapy is the usual dosage of Avastin
  While concomitant use with bolus IFL the dose is
  5mg/kg of Avastin for every 2 weeks IV. While in
  combination with FOLFOX4 the dose is 10mg/kg
  ofAvastin for every 2 weeks IV 5mg/kg IV Avastin
  for every 2 weeks or 7.5 mg/kg Avastin as IV
  every 3 weeks by concurrently used with
  fluoropyrimidine Irinotecan or fluoropyrimidine
  oxaliplatin based therapyNON-SMALL CELL LUNG
  CANCER

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Dosage Management

• While combining with carboplatin and paclitaxel
  The Avastin 100mg Injection usual dosage is
  15mg/kg IV for every 3 weeks byGLIOBLASTOMA
•  For every 2 weeks 10mg/kg of
  Avastinadministered IVMETASTATIC CERVICAL CANCER
•  Combining with paclitaxel and cisplatin or with
  paclitaxel and topotecan The drug Avastin usual
  dosage is 15mg/kg of Avastin 100mg given
  intravenously for every 3 weeks

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METASTATIC RENAL CELL CANCER

• Concurrent use with interferon alfa The
  Avastinusual dosage is 10mg/kg IV for every 2
  weeks

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EPITHELIAL OVARIAN, FALLOPIAN TUBE OR PERITONEAL
CANCER

•  Platinum opposing Concurrent use with
  paclitaxel, pegylated liposomal doxorubicin or
  topotecan The Avastin regular dosage is 10mg/kg
  of Avastin 100mg Injection for every 2 weeks Or
  Combining with topotecan The Avastin regular
  dosage 15mg/kg ofAvastin given through IV for
  every 3 weeks Platinum responsive concomitant
  with carboplatin and paclitaxel for 6 to 8 cycles
  The drug Avastinrecommended dosage of is
  15mg/kg given IV for 3 weeks Combining with
  gemcitabine carboplatin for 6 to 10 cycles
  The Avastin recommended dosage is 15mg/kg of
  Avastin given IV for 3 weeks

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PREPARATION ADMINISTRATION

• Avastin is intravenous solution At initial
  infusion given IV infusion over 90 minutes
  Following infusions give second infusion over 60
  minutes, if tolerated Administer all following
  infusion over 30minutes Avastin IV infusion is
  prepared in aseptic condition Avastin 400mg
  containing 16ml solution whereas 100mg containing
  4ml Avastindilute into 100ml of 0.9 NS Do not
  dilute with dextrose solution Dispose the
  remaining portion of medicine which is left in a
  vial

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