Avastin 100mg - Anticancer drugs | view uses, side effects and price | MHP

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BEVACIZUMABAVASTIN100mgMHP
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DESCRIPTION

• Bevacizumab is a drug sold under the name
  of Avastin 100mg(BEVACIZUMAB) and which is
  categorized as monoclonal anti-body
  anti-angiogenesis.
•  
• When Avastin 100mg tablet concomitant use with
  human monoclonal antibody IgG1, that circumstance
  and prohibits the biological action of human
  vascular endothelial growth factor (VEGF).

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USAGE

• Avastin 100mg is indicated for the treatment of
  some of the conditions like Metastatic colon or
  rectal cancer Non-squamous, non-small cell lung
  cancer Glioblastoma Metastatic renal cell cancer.
• Metastatic cervical cancer Epithelial ovarian,
  fallopian tube or peritoneal cancer.

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MECHANISM OF ACTION

• Avastin 100mg tablet comprises an active compound
  like Bevacizumab which binds to VEGF and avoid
  the communication of VEGF to its receptors like
  Flt-1 KDR) present on the surface of the cells
  This interaction prevents endothelial cell
  multiplication and new blood vessel production
  occurs Hence in counts cessation of metastatic
  cancer cells development happens.

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PROPERTIES

•       Ingredients  Bevacizumab
•     Strength  100mg/4ml 
•     Package  400mg of Bevacizumab containing
  vial

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ADME PROPERTIES

• Distribution
• The volume of distribution is 2.9 (22) L
• Elimination
•  
• The Bevacizumab half life period is 20days (11 to
  50days)

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DOSAGE MANAGEMENT

• KEY POINT
•                    Avoid administration
  of Avastin 100mg tablet before at least 28 days
  following surgery and the wound is completely
  cured.

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METASTATIC COLORECTAL CARCINOMA

•                Concomitant use with
  5-fluorouracil based chemotherapy is the usual
  dosage of Avastin 100mg 

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• While concomitant use with bolus IFL the dose is
  5mg/kg of Avastin for every 2 weeks IV. While in
  combination with FOLFOX4 the dose is 10mg/kg of
  Avastin for every 2 weeks IV 5mg/kg IV Avastin
  for every 2 weeks or 7.5 mg/kg Avastin as IV
  every 3 weeks by concurrently used with
  fluoropyrimidine Irinotecan or fluoropyrimidine
  oxaliplatin based therapy.

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NON-SMALL CELL LUNG CANCER

• While combining with carboplatin and paclitaxel
  The Avastin 100mg tablet usual dosage is 15mg/kg
  IV for every 3 weeks by

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NON-SMALL CELL LUNG CANCER
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GLIOBLASTOMA

•                     For every 2 weeks 10mg/kg
  of Avastin 100mg administered IV

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METASTATIC CERVICAL CANCER

•                   Combining with paclitaxel and
  cisplatin or with paclitaxel and topotecan The
  drug Avastin 100mg tablet usual dosage is 15mg/kg
  of Avastin 100mg given intravenously for every 3
  weeks

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METASTATIC RENAL CELL CANCER

•                       Concurrent use with
  interferon alfa The Avastin 100mg tablet usual
  dosage is 10mg/kg IV for every 2 weeks

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EPITHELIAL OVARIAN, FALLOPIAN TUBE OR PERITONEAL
CANCER

•                     Platinum opposing Concurrent
  use with paclitaxel, pegylated liposomal
  doxorubicin or topotecan The Avastin
  100mg regular dosage is 10mg/kg of Avastin for
  every 2 weeks Or Combining with topotecan
  The Avastin 100mg regular dosage 15mg/kg
  of Avastin 100mg given through IV for every 3
  weeks Platinum responsive concomitant with
  carboplatin and paclitaxel for 6 to 8 cycles

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• The drug Avastinrecommended dosage of is 15mg/kg
  given IV for 3 weeks Combining with gemcitabine
  carboplatin for 6 to 10 cycles The Avastin
  100mg tablet recommended dosage is 15mg/kg of
  Avastin given IV for 3 weeks.

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PREPARATION ADMINISTRATION

•    Avastin 100mg tablet is intravenous solution
  At initial infusion given IV infusion over 90
  minutes Following infusions give second infusion
  over 60 minutes, if tolerated Administer all
  following infusion over 30minutes Avastin
  100mg IV infusion is prepared in aseptic
  condition Avastin 400mg containing 16ml solution
  whereas 100mg containing 4ml Avastin dilute into
  100ml of 0.9 NS Do not dilute with dextrose
  solution Dispose the remaining portion of
  medicine which is left in a vial.

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PRECAUTIONS

• There are some complications occurred during
  treatment with Avastin , care should be taken
  Arterial thromboembolic events cessation of
  treatment with Avastin 100mg tablet in patients
  who are suffered with severe ATE. Venous
  thromboembolic events Toxicity Incidence should
  be detected If severe condition therapy should
  be stopped. 

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•             Hemorrhage While on Avastin
  100mg treatment some Serious hemorrhages will
  occur like GI hemorrhage, hemoptysis,
  Hematemesis, CNS hemorrhage, nose bleeding
  vaginal bleeding. Hence Discontinue the
  treatment. Hypertension Bp is increased in
  patients who are receiving Avastin therapy, must
  be frequently check up with blood pressure and
  provided with alternative medication for correct
  the pressure. In hypertension crisis or
  encephalopathy should be discontinue the
  treatment. 

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• Posterior reversible encephalopathy syndrome
  Embryo fetal toxicity occurs During pregnancy
  condition Avastin 100mg is contraindicated which
  produce fetal harm. Ovarian failure The patients
  who are receiving Avastin may have a chance of
  getting ovarian failure. Congestive heart
  failure the drug combination with anthracycline
  based chemotherapy, treatment with Avastin 100mg
  tablet must not be used. Avastin treatment should
  be stopped while CHF occurs.

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SIDE EFFECTS

•         Gastrointestinal perforation and fistulae
  Surgery and wound healing complication Hemorrhage
  Arterial thromboembolic events Venous
  thromboembolic events Hypertension Posterior
  reversible encephalopathy syndrome Renal injury
  Proteinuria Infusion reactions Ovarian failure
  Congestive heart failure Neutropenia, mucosal
  inflammation, infection, neuropathy, Epistaxis,
  erythrodysaesthesia

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• PREGNANCY LACTATION
• Pregnancy category 
•          D While administrating Avastin 100mg in
  pregnant women, positive evidence on fetal risk
  depends on human studies but potential benefits
  by using the drug may have common risk against
  fetus.Avastin 100mg tablet is excreted into
  breast milk taking account on this, discussion
  should done on whether to discontinue the breast
  feeding or the drug. The drug is risky during
  mother breast feeding to their infants.

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• STORAGE
•     The drug stored at 2 to 8C (36 to 46F)
  Single use vial Dispose the left out vial under
  the guidance of pharmacists.
• MISSED DOSE
•       The dose missed by patient should have the
  dose immediately before the next dose timing
  reaches, or leave the missed dose and continue
  the regular schedule. Remember do not have double
  dose at a time Please consult with doctor for
  further details

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CONTACT US

• MAIL ID        millionhealthpharmaceuticals_at_
  gmail.com 
•    PHONE NO   91-9940472902
•    WEBSITE      https//millionpharma.com/bevaciz
  umab.php

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