ADLUBE - PowerPoint PPT Presentation

Title: ADLUBE


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WELCOME
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• What makes you
• "REFRESH"
• every Morning?

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(No Transcript)
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(No Transcript)
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Lets you sleep on your DRY EYE
symptoms
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IN THE MORNING
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Awake with your EYES feeling REFRESHED
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Refresh Your Dry Eyes With

• ADLUBE

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DRY EYE

• Dry eye is a disease of the ocular surface
  attributable to different disturbances of the
  natural function and protective mechanisms of the
  external eye, leading to an unstable tear film
  during the open eye state.

Surv Ophthalmol 2001 45(2), S199-202
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Dry eye

• Also known as
• Keratoconjunctivitis sicca (KCS)
• Dry Eye Disease (DED)
• Dry Eye Syndrome (DES)
• Ocular Surface Disease (OSD)

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Symptoms

• Irritation
• Redness
• Burning/ Stinging
• Itchy eyes
• Sandy- gritty feeling (foreign body sensation)
• Blurred vision
• Tearing
• Contact lens intolerance.
• Increased frequency of blinking
• Mucous discharge.
• Photophobia (less frequent symptom)
• Symptoms worsen in windy or air-conditioned
  environments.
• As day progresses.
• After prolonged reading, working on computers

Supl PT Digest 2003, 28(12), 1-45
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• Dry eye can be a chronic, debilitating condition.
• Persistent, uncontrolled dry eye can lead to
  corneal erosions, corneal defects and in severe
  cases corneal ulcers.

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Dry eye may be sight-threatening

• Bacterial Keratitis

Corneal ulcer
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• Dry Eye
• Affects Quality of Life

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Dry Eye Main Causes
Clin Exp Optom 2001 84 1 4-18
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DRY EYE MANAGEMENT
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Management of Dry Eye
Late KCS
Lubricating eye ointment
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ADLUBE
Introducing for the first time , preservative
free
STERILE PRESERVATIVE FREE OCULAR
LUBRICATING OINTMENT

• White Soft Paraffin ( 57.3) and Liquid
  Paraffin (42.5)

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PHARMACOLOGY

• When white soft paraffin is applied to the
  lower eyelid, it melts at skin temperature and
  gradually moves over the skin on to the ocular
  surface in a time released fashion. This movement
  of petrolatum is termed supracutaneous.
• Forms an occlusive film over the surface of
  the eyeball and improve the composition of the
  tear film by enhancing the mucin and aqueous
  layers.
•  

http//dry.org/petrolatum.html ,
http//www.drugstorenews.com
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PHARMACOLOGY (Contd.)

• Slows evaporation of the tear film.
• Thus, it breaks the vicious cycle in which dry
  eye leads to blepharitis which leads to dry eye.
• Prevents frictional damage to the ocular surfaces
  secondary to lid movement or extra ocular
  movements.
• Acts by retaining fluid and maintaining hydration
  of the ocular surface.
•  

http//dry.org/petrolatum.html , Soosan Jacob and
et al, Management Miscellaneous Modalities, Dry
Eye, 2006 pg183
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PHARMACOKINETICS

• Onset of action begins within 10 minutes of
  application, peak at 30 minutes, while
  concentrations at 6 hours were still at levels
  near 20 of peak concentration.
• White soft paraffin remains in the eye for a
  longer time.

http//dry.org/petrolatum.html
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AD-LUBE EFFICACY

• There are studies and case histories evaluating
  efficacy of white soft paraffin . These conclude
  that

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ADLUBE EFFICACY HIGHLIGHTS

• Effective in reducing evaporation rate and
  blinking rates in patients with dry eye.
• Prevents dessication from corneal tear film.
• Statistical significant improvement observed in
  subjective symptoms of vital staining of ocular
  surface.

British Journal of Ophthalmology, 1999 83
767-770
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ADLUBE EFFICACY HIGHLIGHTS

• Reduces burning sensation in patients with dry
  eye and blepharitis.
• Reduces reflex tearing in patients with dry eye
  and blepharitis.
• Reduces the need for artificial tears and warm
  compressors.

http//dry.org/petrolatum.html
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ADLUBE EFFICACY CONCLUSION

• Well tolerated by the patients, and provides a
  totally new therapeutic approach providing steady
  levels of medication to the ocular surface which
  offers additional benefits in the management of
  dry eye.

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ROLE OF WHITE SOFT PARAFFIN IN CRITICALLY ILL
PATIENTS

• Microbial keratitis has been reported among
  critically ill patients and the need for
  effective eye care in the intensive care unit
  (ICU) has been recognised for some time.
• A recent survey in UK found that 25 of ICUs
  used ocular lubricants as eye care.

British Journal of Ophthalmology,
2005891068-1069
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ROLE OF WHITE SOFT PARAFFIN IN CRITICALLY ILL
PATIENTS

• A condition where the Patient does not close its
  eyes completely when sleeping, causing the drying
  of the cornea, Inflammation and irritation of the
  cornea.
• Studies documenting in ICU patients who developed
  exposure keratitis using white soft paraffin
  proved that it is effective.

British Journal of Ophthalmology,
2005891068-1069
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ADLUBE

• FIRST PRESERVATIVE FREE OCULAR OINTMENT

PET Done
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RESULTS OF PRESERVATIVE EFFICACY TEST

• CONCLUSION
• The sample is preserved efficiently.
• REULTS
• As evident from preservative efficacy data,
  ADLUBE is self preserved and does not require any
  additional preservative.

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INDICATIONS

• For the temporary relief of burning, irritation
  and discomfort due to dryness of the eye or due
  to exposure to wind or sun.
• Also may be used as a protectant against further
  irritation.

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OTHER INDICATIONS

• Exposure keratitis
• Decreased corneal sensitivity
• Recurrent corneal erosions
• Blepharitis
• Lids and conjunctival problems
• Tearfilm problems

http//www.internationalebforum.org/upload/The_ey
es_and_EB.pdf , http//www.emc.medicine.org.uk
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Dosage and administration

• For topical Ocular administration.
• Wash the hands before use.
• Pull down the lower lid of the affected eye and
  apply a small amount (one fourth inch) of
  ointment to the inside of the eyelid. (Ideal for
  use at bedtime).
• There is no variation in dosage for age.
• To avoid contamination, do not touch tip of the
  container to any surface. Replace cap after
  using.

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CONTRAINDICATIONS

• Contraindicated in patients hypersensitive to any
  of the ingredient in the product or lanolin
  alcohols.
• Contraindicated for use in bacterial, viral or
  fungal infections in the eye, unless used along
  with an anti infective medicine.

http//www.talkmedical.com/medications/print-5289,
http//www.emc.medicine.org.uk
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PRECAUTIONS AND WARNINGS

• To avoid contamination during use, do not touch
  the tube tip to any surface.
• If irritation, pain, redness and changes in
  vision occur or worsen, treatment discontinuation
  should be considered and a re-evaluation of the
  patient's condition should be made.

http//www.emc.medicine.org.uk
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PRECAUTIONS AND WARNINGS

• Contact lenses should not be worn during
  instillation of the drug. After instillation
  there should be an interval of at least 30
  minutes before reinsertion.
• Concomitant topical ocular medication if
  necessary, there should be an interval of at
  least 5 minutes between the two medications.
  AD-LUBE should always be the last medication
  instilled.

http//www.emc.medicine.org.uk
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DRUG INTERACTIONS

• No interactions have been observed with
  ADLUBE, since the constituents have a well
  established medicinal use, no interactions are
  anticipated.

http//www.emc.medicine.org.uk
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SAFETY IN SPECIAL POPULATION

• IT IS SAFE FOR USE IN
• Pregnancy
• Breast feeding
• Women of child bearing age
• Children
• Elderly Patients

http//www.talkmedical.com/medications/print-52
89, http//www.emc.medicine.org.uk
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ADVERSE EFFECTS

• ADLUBE is safe for ophthalmic use.
• It is non-toxic and proved for food and medicinal
  use.
• It causes temporary blurring of eye vision which
  may last for 1-15 minutes.
• Irritation, stinging and burning sensations have
  been observed rarely (1/10,000,
• Allergic reactions, pain hyperemia and
  conjunctivitis have been reported very rarely
  (
• Isolated reports of oedema and pruritus have been
  seen.

http//www.petrogel.com/msds-c.pdf ,
http//www.emc.medicine.org.uk
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HIGHLIGHTS

• FIRST STERILE PRESERVATIVE FREE ocular
  lubricating ointment.
• One of the BEST ocular lubricant combination.
• It has no preservative hence, gentle enough to
  be used as often as needed without damaging the
  eye vision.
• Thicker and greasier and hence, stays in eye for
  a much longer time than eye drops.
• Safe and effective for dry eye.

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HIGHLIGHTS

• Provides long lasting relief for dry eye.
• Prevents abrasion at night.
• Reduces need for artificial tears and warm
  compressors.
• A new therapeutic approach to provide steady
  levels of medication to ocular surface.
• Prevents brittleness and / or breaking of
  eyelashes.

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• THANKYOU