NanoBioIT Where weve been and where we are going - PowerPoint PPT Presentation
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NanoBioIT Where weve been and where we are going
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1965 Mini-Computer (PDP 8, DEC)/1966 Genetic code defined as sequence of codons ... Regenerative Medicine (autographs)** Gene replacement therapy (in utero and adult) ... – PowerPoint PPT presentation
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Title: NanoBioIT Where weve been and where we are going
1
Nano-Bio-ITWhere weve been and where we are
going
- Christopher A. Royse
- Adjunct Professor, GWU
- Student, GMU BIOMAN
- Deputy Task Leader, SAIC-TRSC
2
Nano-Bio-ITWhere Weve Been
- Throughout History there has been a linkage
between advances in Information Technology and
advances in Biotechnology. - Example
- 1944 Mark I Computer Developed Publication DNA
as genetic material in bacteria - 1965 Mini-Computer (PDP 8, DEC)/1966 Genetic code
defined as sequence of codons - 1981 IBM PC/Microsoft DOS/1982 First rDNA drug
approved by FDA (human insulin) - Mid 1990s WWW/1997 Sheep cloning from adult
cells - Simon and Kotler. Building Global Biobrands.
Pg. 9
3
Nano-Bio-ITWhere Weve Been
- Both disciplines push the other yet there is
very little linkage between the two in budgeting
and program management - Linking RD to revenue builds a camp mentality
4
Nano-Bio-ITWhere We Are Going
- Dr. Francis Collins predictions-next 40 years
(Natl Institute of Human Genome Research) - Nano-Bio
- Nano-Bio-IT
- 1-5 Years
- Expansion of molecular diagnostic tests
- Identification of molecular subtypes of major
disease - Simon and Kotler. Building Global Biobrands.
Pg. 10
5
Nano-Bio-ITWhere We Are Going
- 10 Years
- Predictive tests for more than 20 genetic
conditions - Growing number of molecular targeted therapies
- Pharmacogenomic markers tracking a patients
responses to drugs - New imaging probes to assess body functions
- Simon and Kotler. Building Global Biobrands.
Pg. 10
6
Nano-Bio-ITWhere We Are Going
- 15-25 Years
- Populations to be tested to determine genotypes
databases to be created - Tailored drugs for diabetes, hypertension,
cancer, and other illnesses - Mass Market therapies-subdivided-different
genotypes - Regenerative Medicine (autographs)
- Gene replacement therapy (in utero and adult)
- Simon and Kotler. Building Global Biobrands.
Pg. 10
7
Nano-Bio-ITWhere We Are Going
- 30 Years
- Aging will be better understood, trials underway
to increase life span - Genomics-based healthcare
- Simon and Kotler. Building Global Biobrands.
Pg. 10
8
Nano-Bio-ITWhere We Are Going
- So why is everything so interconnected among the
three? - Key areas already being researched
- Drug delivery/discovery
- Tissue and structural repair
- Sensors for monitoring and diagnoses
- Surgical assistance/Robotics
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Nano-Bio-ITWhere We Are Going
- Drug delivery/discovery
- Buckyballs shaped to fit into cell surface
receptorscoated with drugs - Simon and Kotler. Building Global Biobrands.
Pg. 25 - Potential entire new area of physiological
monitoring and data collection
10
Nano-Bio-ITWhere We Are Going
- Tissue and structural repair
- Design and modeling
- Sensors for monitoring and diagnoses
- Implantable/circuit sizes drop to 0.01
micron-DARPA projectmolecules have electrical
and chemical properties - Simon and Kotler. Building Global Biobrands.
Pg. 25
11
Nano-Bio-ITWhere We Are Going
- Surgical assistance/Robotics
- Interview with Drs. Hwang and Moon, first to
clone human embryo - MOON Also, there is something special about Dr.
Hwang's lab. It's something in our Korean
culture. The micromanipulation that we did for
the cloning, it's a very tedious job. But people
from our part of the world are very patient, and
that helped. Our researchers had an almost
Zen-like sense of concentration they could sit
for 10 hours in one spot and carefully manipulate
the eggs. It was almost like a meditation. - Dreifus, C. 2 Friends, 242 Eggs and a
Breakthrough. NYT. 17 FEB 2004, D1
12
Nano-Bio-ITSo, whats the concern?
- Everyone of these
- Key areas already being researched
- Drug delivery/discovery
- Tissue and structural repair
- Sensors for monitoring and diagnoses
- Surgical assistance/Robotics
- Has a potential Application to an Offensive (to
Humans) Biological Warfare Program
13
Nano-Bio-ITSo, whats the concern?
- Drug delivery/discovery
- Research underway potentially improves components
of offensive (to Humans) delivery
techniques-requires advance modeling and large
databases - Tissue and structural repair
- Degeneration-hardware
- Sensors for monitoring and diagnoses
- Potential to circumvent current/emerging
technologies-software - Surgical assistance/Robotics
- Reduces the need for humans in BSL areas for
micromanipulation-wireless
14
Nano-Bio-ITSo, what can be done?
- We are on the edge of a new scientific frontier
combining the advances of the end of the 20th and
the beginning of the 21st centuries-three fields
converging - We should learn from the past-it is no secret
that Bio-IT advances have a historical
relationship - Nor is it a secret that there are people aiming
to obtain or improve upon existing offensive (to
Humans) biological warfare programs
15
Nano-Bio-ITSo, what can be done?
- Should learn from history
- Should develop internationally accepted standards
and protocols for work among these disciplines,
due diligence protocols, and punishments for
nefarious uses - Should fund the development of capabilities to
conduct forensic examinations of items (evidence)
which is derived from a combination of these
disciplines
16
References
- Dreifus, Claudia. 2 Friends, 242 Eggs and a
Breakthrough. The New York Times. February 17,
2004 D1. - Simon, Francoise and Philip Kotler. Building
Global Biobrands. Free Press, NY, NY, 2003. - Yang, Frank ISTN. Presentation Nanotechnology
The Life Sciences. October 3, 2003 Northern
Virginia Technology Council, BioMedTech Committee.
17
Nano-Bio-IT
- Chris Royse
- Adjunct Professor, GWU
- Student, GMU BIOMAN
- Deputy Task Leader, SAIC-TRSC
- Deputy Task Leader
- SAICs Threat Reduction Support Center
- Chrisroyse1_at_comcast.net
- Croyse_at_gmu.edu
- 202-413-4457 Cell
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