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Noeplasia II Epidemiology of Cancer
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Noeplasia II Epidemiology of Cancer Husni Maqboul, M.D Epidemiology Of Cancer EVERY BODY HAS HIS CANCER, HE JUST HAS TO LIVE LONG ENOUGH TO GET IT Cancer, Endogenous ... – PowerPoint PPT presentation
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Title: Noeplasia II Epidemiology of Cancer
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Noeplasia IIEpidemiology of Cancer
- Husni Maqboul, M.D
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Epidemiology Of Cancer
- Cancer A significant health problem, second only
to heart disease with regard to morbidity and
mortality - Responsible for 564,000 deaths in 1998
- Accounted for 23 of all deaths
- Residents of U.S.A. have a one in five chance of
dying of cancer - Over 1,000,000 new cases each year (excluding 1
mln. cases of non-melanoma skin cancer )
- EVERY BODY HAS HIS CANCER, HE JUST HAS TO LIVE
LONG ENOUGH TO GET IT
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Cancer, Endogenous Exogenous factors
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Cancer, Exogenous endogenous factors
- The only certain way of avoiding cancer is
not to be born !!!!!
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Environmental Carcinogens
- Drugs antineoplastic, immune suppressing etc..
- Organic chemicals Insecticides, herbicides,
aromatic hydrocarbons, etc.. - Cigarette Smoke
- Ethanol
- Heavy Metals
- Sexually transmitted viruses HTLV-I, Herpes
simplex, Human papilloma virus - Radiation Ultraviolet light
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Age and Cancer
- Cancer Mortality by Age for Males
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Cancer Mortality by Age for Females
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Heredity and Cancer
- Hereditary predisposition
- Clustering of environmentally induced cancers in
families. - Close relatives of cancer patients have three
times greater risk of developing the same
neoplasm. - Close relatives of patients with breast, colon,
or endocrine cancers have greater than three
times risk for developing the same neoplasm. - Increased cancer risk with inherited mutations of
cancer suppressor genes such as Rb and p53.
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Heredity and Cancer
- Inherited Cancer Syndromes
- Specific sites and tissue involved in each
syndrome - Tumors often associated with specific marker
phenotype ( benign tumors, café-au-lait spots ) - Incomplete penetrance and variable expressivity
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Heredity and Cancer
- Familial Cancers
- Early age of onset
- Tumors arise in two or more close relatives
- Some times multiple and bilateral
- No specific marker phenotype
- ? Inherited or mutant genes e.g BRCA-1 BRCA-2
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Heredity and Cancer
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Acquired Preneoplastic Syndromes
- Proliferative lesions
- Regenerative cell replication
- Hyperplastic proliferation
- Neoplastic - Villous and tubular adenomas
- Dysplastic lesions
- Clinically correlated
- Atrophic gastritis
- U.C and Crohns disease
- Leukoplakia
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