P1258758026TUvVu - PowerPoint PPT Presentation
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Title: P1258758026TUvVu
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Lecture 29
- Hand in LP 9/10
- Quiz 8 Review
- Course evaluation
- Next Lecture
- Quiz 8
- This Week in Lab
- Synthetic 2 Final Report Due
- Remember to bring all graded PreLabs and Aldrich
to lab - Clean up and check-out!
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Quiz 8
- Questions on
- Reactions/synthetics that were gone over in
class - Mechanisms of reactions from lecture
- Special topics
- Drug discovery
- Retrosynthetic analysis
- Molecular modification
- Sweeteners (saccharin, aspartame, sucralose)
- Lab application questions - comprehensive
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Quiz 8
Reactions Nitrile reaction (synthesis of
creatine) Substitution (Sn2) reactions (plant
hormone norleucine) Acyl substitution reaction
(synthesis of OFF)
- Reductions
- Of alkenes (hydrogenation of olive oil)
- Of carbonyls (with hydride ion)
- Esterifications
- Transesterification (synthesis of
3-carbethoxycoumarin) - Fisher esterification (benzocaine others)
- Alternative (with anhydrides synthesis of
aspirin) - Enolate Chemistry
- Aldol Condensation (synthesis of
3-carbethoxycoumarin)
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Quiz 8
- Reactions
- Be able to draw out the mechanisms of only those
- that were given in lecture. Know the reagents
- used for each reaction.
- Special topics
- Drug discovery process (nakadomarin A taxol)
- Retrosynthetic analysis
- Molecular modification (cocaine related
compounds) - Sweeteners know the synthetic pathways to
aspartame - and sucralose
- Be able to identify a compound
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Quiz 8
- Lab Application Sample Questions
- Susie is running out of time, but she wants to
obtain a melting point - reading before the end of the lab period. She
turns the dial on the - Mel-Temp up to 7, and the temperature rises at
about 10C per minute. - Is this proper technique to obtain an accurate
melting point? - Why or why not?
- 2. You run a TLC to determine if your reaction
has run to - completion, and you observe the results shown on
the plate below. - Did your reaction run to completion? How do you
know?
SM CO Rxn
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Practice Quiz Problems
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LP 9/10
1
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LP 9/10
2. Identify the nucleophile electrophile.
Circle the sites of reactivity on each.
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