605 Topoisomerases PPTs View free & download

DNA topoisomerases in vivo PowerPoint PPT Presentation

DNA topoisomerases in vivo - in vivo Dr. Sevim I k Type II mechanism Reactions catalysed by topoisomerases Prokaryotes: Reactions catalysed by topoisomerases Eukaryotes: Functions of ...

in vivo Dr. Sevim I k Type II mechanism Reactions catalysed by topoisomerases Prokaryotes: Reactions catalysed by topoisomerases Eukaryotes: Functions of ...

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Local unwinding during replication results in overwinding or supercoiling of surrounding regions PowerPoint PPT Presentation

Local unwinding during replication results in overwinding or supercoiling of surrounding regions - Local unwinding during replication results in overwinding or supercoiling of ... Wasserman & Cozzarelli, Science 1986. Topoisomerases. Type I topoisomerases: ...

Local unwinding during replication results in overwinding or supercoiling of ... Wasserman & Cozzarelli, Science 1986. Topoisomerases. Type I topoisomerases: ...

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Topological Problems in Replication PowerPoint PPT Presentation

Topological Problems in Replication - Topological Problems in Replication Linear Chromosomes: Telomerase for replication of the ends Topoisomerases to relieve strain of untwisting and supercoiling

Topological Problems in Replication Linear Chromosomes: Telomerase for replication of the ends Topoisomerases to relieve strain of untwisting and supercoiling

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Single Supercoiled DNAs PowerPoint PPT Presentation

Single Supercoiled DNAs - Single Supercoiled DNAs DNA Supercoiling in vivo In most organisms, DNA is negatively supercoiled (s ~ -0.06) Actively regulated by topoisomerases, ubiquitous and ...

Single Supercoiled DNAs DNA Supercoiling in vivo In most organisms, DNA is negatively supercoiled (s ~ -0.06) Actively regulated by topoisomerases, ubiquitous and ...

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PROPERTIES OF DNA II. PowerPoint PPT Presentation

PROPERTIES OF DNA II. - PROPERTIES OF DNA II. Supercoiling and Topoisomerases The E. coli chromosome 2 puzzles 1. It was circular and twisted 2. Chromatograph showed evenly spaced bands ...

PROPERTIES OF DNA II. Supercoiling and Topoisomerases The E. coli chromosome 2 puzzles 1. It was circular and twisted 2. Chromatograph showed evenly spaced bands ...

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Indenoisoquinolines PowerPoint PPT Presentation

Indenoisoquinolines - and polarity (5' vs. 3' tyrosyl linkage) of human topoisomerases ... 200X enlargement. 200X enlargement. Samples from 4 mice (40X) ...

and polarity (5' vs. 3' tyrosyl linkage) of human topoisomerases ... 200X enlargement. 200X enlargement. Samples from 4 mice (40X) ...

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From antimalarial to antibacterial PowerPoint PPT Presentation

From antimalarial to antibacterial - Inhibition of topoisomerases a family of enzymes responsible for maintaining ... Torsades de pointe: paroxysm of ventricular tachycardia in which the ...

Inhibition of topoisomerases a family of enzymes responsible for maintaining ... Torsades de pointe: paroxysm of ventricular tachycardia in which the ...

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Single and Doublestrand PowerPoint PPT Presentation

Single and Doublestrand - 1.5 x 105 per cell per day. Andrew J. Pierce. TOX 780. Polb ... Rag 1/2. Spo11. Enzymatic Failure. Topoisomerases. Replication forks ...

1.5 x 105 per cell per day. Andrew J. Pierce. TOX 780. Polb ... Rag 1/2. Spo11. Enzymatic Failure. Topoisomerases. Replication forks ...

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Biology is based on the most complex chemical systems known to man' PowerPoint PPT Presentation

Biology is based on the most complex chemical systems known to man' - Helicase DnaB unwinds OriC fragments (DnaC helps to load helicase DnaB) ... unwind the double helix. Topoisomerases reduces torsional stress during unwinding of ...

Helicase DnaB unwinds OriC fragments (DnaC helps to load helicase DnaB) ... unwind the double helix. Topoisomerases reduces torsional stress during unwinding of ...

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HOMOLOGY MODELLING OF HUMAN TOPOISOMERASE IIa USING YEAST TOPOISOMERASE II AS A TEMPLATE PowerPoint PPT Presentation

HOMOLOGY MODELLING OF HUMAN TOPOISOMERASE IIa USING YEAST TOPOISOMERASE II AS A TEMPLATE - DNA topoisomerases are ubiquitous molecular machines that regulate the topology ... Biochemistry. 2001 Dec 18;40(50):15153-63. Liu L. Unpublished data ...

DNA topoisomerases are ubiquitous molecular machines that regulate the topology ... Biochemistry. 2001 Dec 18;40(50):15153-63. Liu L. Unpublished data ...

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DenaturationRenaturation PowerPoint PPT Presentation

DenaturationRenaturation - Denaturation/Renaturation. Denaturation: separation of the 2 strands of the ... Toroid or. spiral. Example: DNA wraps around. histone protein core within nucleosomes; ...

Denaturation/Renaturation. Denaturation: separation of the 2 strands of the ... Toroid or. spiral. Example: DNA wraps around. histone protein core within nucleosomes; ...

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DNA Topology DNA has to be coiled to fit inside the cell PowerPoint PPT Presentation

DNA Topology DNA has to be coiled to fit inside the cell - Stabilizes topoisomerase I-DNA intermediate, preventing DNA strand re-ligation ... There are enzymes that will cut DNA, ligate DNA, and change the topology of DNA. ...

Stabilizes topoisomerase I-DNA intermediate, preventing DNA strand re-ligation ... There are enzymes that will cut DNA, ligate DNA, and change the topology of DNA. ...

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Molecular Basis for PowerPoint PPT Presentation

Molecular Basis for - Molecular Basis for Relationship between Genotype and Phenotype DNA genotype DNA sequence transcription replication RNA translation amino acid sequence

Molecular Basis for Relationship between Genotype and Phenotype DNA genotype DNA sequence transcription replication RNA translation amino acid sequence

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Supercoiling of DNA PowerPoint PPT Presentation

Supercoiling of DNA - E. Unraveling the DNA at one position changes the superhelicity ... A. Gel electrophoresis. i. 1 dimensional. ii. 2 dimensional. B. Density sedimentation ...

E. Unraveling the DNA at one position changes the superhelicity ... A. Gel electrophoresis. i. 1 dimensional. ii. 2 dimensional. B. Density sedimentation ...

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Camptothecin PowerPoint PPT Presentation

Camptothecin - Strand unwinding at the replication fork during DNA replication, causes the ... The torsional stress at the pre-fork region must be relieved or the strand ...

Strand unwinding at the replication fork during DNA replication, causes the ... The torsional stress at the pre-fork region must be relieved or the strand ...

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What is cancer? PowerPoint PPT Presentation

What is cancer? - Cancer is the biggest concern in nowadays, In USA every one person in four dies due to cancer. There are various treatment options are available to treat Cancer

Cancer is the biggest concern in nowadays, In USA every one person in four dies due to cancer. There are various treatment options are available to treat Cancer

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REPLICATION - GENETICS

GENETICS

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Part Two of BMB 400 PowerPoint PPT Presentation

Part Two of BMB 400 - ... Replicon = unit that controls replication Theta-form replication intermediates visualized in EM for polyoma virus Labeling of ... 21 Protein gene function ...

... Replicon = unit that controls replication Theta-form replication intermediates visualized in EM for polyoma virus Labeling of ... 21 Protein gene function ...

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Nucleic Acid Chemistry PowerPoint PPT Presentation

Nucleic Acid Chemistry - Biochemistry

Biochemistry

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Genomes, DNA Structure and Topology PowerPoint PPT Presentation

Genomes, DNA Structure and Topology - DNA structure/topology. Genomes are longer than the cells in which they are packaged ... Review of Watson/Crick DNA Structure. major groove. minor groove. 34 ...

DNA structure/topology. Genomes are longer than the cells in which they are packaged ... Review of Watson/Crick DNA Structure. major groove. minor groove. 34 ...

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DNA - Parent strands transfer information to an intermediate, then the. intermediate gets copied. ... DNA helicase moves along one strand of the DNA ...

Parent strands transfer information to an intermediate, then the. intermediate gets copied. ... DNA helicase moves along one strand of the DNA ...

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Genome Organisation I PowerPoint PPT Presentation

Genome Organisation I - Positive supercoiling is in the same direction as the helix. Negative supercoils, when unwound, cause the helix to become partly strand-separated ...

Positive supercoiling is in the same direction as the helix. Negative supercoils, when unwound, cause the helix to become partly strand-separated ...

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Nucleic acids Part 2' PowerPoint PPT Presentation

Nucleic acids Part 2' - Wind or unwind. Rejoin ends. There is both positive and negative. supercoiling. ... provides energy for local unwinding.. Local unwinding is necessary for ...

Wind or unwind. Rejoin ends. There is both positive and negative. supercoiling. ... provides energy for local unwinding.. Local unwinding is necessary for ...

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Genetic Engineering Lab PowerPoint PPT Presentation

Genetic Engineering Lab - ... genes -lactamase can destroy penicillin and other -lactam antibiotics Kanamycin interferes with Ribosomes Plasmids can be cut with restriction enzymes ...

... genes -lactamase can destroy penicillin and other -lactam antibiotics Kanamycin interferes with Ribosomes Plasmids can be cut with restriction enzymes ...

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DNA Replication I: Basic Mechanism and Enzymology PowerPoint PPT Presentation

DNA Replication I: Basic Mechanism and Enzymology - Mix DNA containing nomal isotope of nitrogen(14N) and DNA labeled with a heavy ... Autoradiograph of replicating embryonic Triturus vulgaris DNA ...

Mix DNA containing nomal isotope of nitrogen(14N) and DNA labeled with a heavy ... Autoradiograph of replicating embryonic Triturus vulgaris DNA ...

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SURVEY OF BIOCHEMISTRY Nucleic Acids PowerPoint PPT Presentation

SURVEY OF BIOCHEMISTRY Nucleic Acids - Number of times one strand makes a complete revolution about the helical axis. ... Function of the new gene product on the host ...

Number of times one strand makes a complete revolution about the helical axis. ... Function of the new gene product on the host ...

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DNA, chromatin and the nucleus PowerPoint PPT Presentation

DNA, chromatin and the nucleus - This allows DNA to unwind for duplication and transcription (S = sugar; P ... for transcription and replication; unwinding/unpairing must occur so that ...

This allows DNA to unwind for duplication and transcription (S = sugar; P ... for transcription and replication; unwinding/unpairing must occur so that ...

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DNA Replication PowerPoint PPT Presentation

DNA Replication - Describe the cellular mechanisms that help avoid error ... Hexameric ring. Separate DNA strands. Use ATP hydrolysis for Energy. Primase. Activated by helicase ...

Describe the cellular mechanisms that help avoid error ... Hexameric ring. Separate DNA strands. Use ATP hydrolysis for Energy. Primase. Activated by helicase ...

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The Organic Chemistry of Drug Design and Drug Action PowerPoint PPT Presentation

The Organic Chemistry of Drug Design and Drug Action - The Organic Chemistry of Drug Design and Drug Action Chapter 6 DNA-Interactive Agents DNA-Interactive Agents Cancer Cells Structure-Based Design of Potential Drugs ...

The Organic Chemistry of Drug Design and Drug Action Chapter 6 DNA-Interactive Agents DNA-Interactive Agents Cancer Cells Structure-Based Design of Potential Drugs ...

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Maintenance and expression of genetic information PowerPoint PPT Presentation

Maintenance and expression of genetic information - Maintenance and expression of genetic information Central Dogma: DNA RNA Protein ssDNA binding proteins are required to iron out the ...

Maintenance and expression of genetic information Central Dogma: DNA RNA Protein ssDNA binding proteins are required to iron out the ...

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Section C - Properties of Nucleic Acids PowerPoint PPT Presentation

Section C - Properties of Nucleic Acids - Section C - Properties of Nucleic Acids Contents C1 Nucleic Acid Structure Bases, Nucleosides, Nucleotides, Phosphodiester bonds, DNA/RNA sequence, DNA double helix ...

Section C - Properties of Nucleic Acids Contents C1 Nucleic Acid Structure Bases, Nucleosides, Nucleotides, Phosphodiester bonds, DNA/RNA sequence, DNA double helix ...

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DUPLICACION DEL MATERIAL GENETICO PowerPoint PPT Presentation

DUPLICACION DEL MATERIAL GENETICO - Pol III holoenzyme of E. coli can synthesize hundreds of ... Also most bacteria that cause enteritis: Salmonella, Shigella, E. coli. ...

Pol III holoenzyme of E. coli can synthesize hundreds of ... Also most bacteria that cause enteritis: Salmonella, Shigella, E. coli. ...

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Research Interests PowerPoint PPT Presentation

Research Interests - ... K, Seki M, Enomoto T, Saitoh H, tsutsui K, 'The SUMO pathway is required for ... The SUMO pathway is required for selective degradation of DNA topoisomerase IIb ...

... K, Seki M, Enomoto T, Saitoh H, tsutsui K, 'The SUMO pathway is required for ... The SUMO pathway is required for selective degradation of DNA topoisomerase IIb ...

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35 Proofreading Repair by Klenow Fragment of DNA pol I PowerPoint PPT Presentation

35 Proofreading Repair by Klenow Fragment of DNA pol I - However, pol III in a multi-protein aggregate termed the ... on lagging strand must bind and dissociate constantly, yet keep at same pace as leading strand ...

However, pol III in a multi-protein aggregate termed the ... on lagging strand must bind and dissociate constantly, yet keep at same pace as leading strand ...

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Topoisomerase Poisons Bound at a DNA Junction-like Quadruplex PowerPoint PPT Presentation

Topoisomerase Poisons Bound at a DNA Junction-like Quadruplex - Topoisomerase Poisons Bound at a DNA Junction-like Quadruplex ... directly influence the helix cross-over and intercalation site, they are ...

Topoisomerase Poisons Bound at a DNA Junction-like Quadruplex ... directly influence the helix cross-over and intercalation site, they are ...

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Techniques Used in Molecular Biology - Techniques Used in Molecular Biology

Techniques Used in Molecular Biology

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Nucleophilic sites on DNA PowerPoint PPT Presentation

Nucleophilic sites on DNA - ... all N and O sites are capable of being alkylated by a strong enough electrophile ... Accessibility of electrophile to sites in major and minor groove. Eg. ...

... all N and O sites are capable of being alkylated by a strong enough electrophile ... Accessibility of electrophile to sites in major and minor groove. Eg. ...

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PRIMING OF DNA SYNTHESIS BY PowerPoint PPT Presentation

PRIMING OF DNA SYNTHESIS BY - PRIMING OF DNA SYNTHESIS BY. SHORT SEQUENCES OF RNA (RED) DNA POLYMERASE USES THE ... Unwinding of DNA leads to tightening of the helix. ...

PRIMING OF DNA SYNTHESIS BY. SHORT SEQUENCES OF RNA (RED) DNA POLYMERASE USES THE ... Unwinding of DNA leads to tightening of the helix. ...

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Enzymes other than polymerases needed for replication PowerPoint PPT Presentation

Enzymes other than polymerases needed for replication - In addition, helicases move along single stranded DNA with a specific polarity; ... 'Sewing machine' model. Types of enzymes at the replication fork ...

In addition, helicases move along single stranded DNA with a specific polarity; ... 'Sewing machine' model. Types of enzymes at the replication fork ...

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Genes - Genes

Genes

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UNIT 11 DNA REPLICATION PowerPoint PPT Presentation

UNIT 11 DNA REPLICATION - REPLICATION INITIATION IN EUKARYOTES. Five DNA polymerases are known in mammalian cells: ... is involved in nuclear DNA replication and has not been shown ...

REPLICATION INITIATION IN EUKARYOTES. Five DNA polymerases are known in mammalian cells: ... is involved in nuclear DNA replication and has not been shown ...

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Techniques Used in Molecular Biology - ... here presented as a great American epiphany - its recipient struck by a flash of ... to note the exact spot, if not the month - the epiphany arrives. ...

... here presented as a great American epiphany - its recipient struck by a flash of ... to note the exact spot, if not the month - the epiphany arrives. ...

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The Nature of the Gene PowerPoint PPT Presentation

The Nature of the Gene - CHAPTER 10 The Nature of the Gene and the Genome Sequencing Genomes: The Footprints of Biological Evolution (5) Structural Variation Segments of the genome can change ...

CHAPTER 10 The Nature of the Gene and the Genome Sequencing Genomes: The Footprints of Biological Evolution (5) Structural Variation Segments of the genome can change ...

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Fig. 1.12 - Departamento de Agroqu mica y Bioqu mica Departament D Agroqu mica i Bioqu mica Genetic information (DNA) mRNA proteins. Transmission of genetic information ...

Departamento de Agroqu mica y Bioqu mica Departament D Agroqu mica i Bioqu mica Genetic information (DNA) mRNA proteins. Transmission of genetic information ...

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Nucleic acid chemistry part 3 : DNA replication - Nucleic acid chemistry part 3 : DNA replication

Nucleic acid chemistry part 3 : DNA replication

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SECTION C - The diffraction pattern from the DNA optical transform shows the central ... (A and G) bases to the ribose ring are broken ], can be generated by formic acid ...

The diffraction pattern from the DNA optical transform shows the central ... (A and G) bases to the ribose ring are broken ], can be generated by formic acid ...

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Welcome to My Molecular Biology Lecture PowerPoint PPT Presentation

Welcome to My Molecular Biology Lecture - Dedicated to the structure of DNA and the processes that propagate (??) ... 3. Two different models illustrate structure a DNA double helix. Schematic model ...

Dedicated to the structure of DNA and the processes that propagate (??) ... 3. Two different models illustrate structure a DNA double helix. Schematic model ...

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Fig. 1.12 - Title: Fig. 1.12 Author: Particular Last modified by: Emma Created Date: 1/25/2005 10:57:58 PM Document presentation format: A4 (210 x 297 mm) Company

Title: Fig. 1.12 Author: Particular Last modified by: Emma Created Date: 1/25/2005 10:57:58 PM Document presentation format: A4 (210 x 297 mm) Company

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??????????(Microbial Genetics and Biotechnology) PowerPoint PPT Presentation

??????????(Microbial Genetics and Biotechnology) - Title: Author: Ho Last modified by: sam Created Date: 2/17/2004 6:08:16 AM Document presentation format: Company

Title: Author: Ho Last modified by: sam Created Date: 2/17/2004 6:08:16 AM Document presentation format: Company

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Welcome to My Molecular Biology Lecture - Dedicated to the structure of DNA and the processes that propagate (??) ... are displaced by base-base interactions, which creates disorder/hydrophobicity ...

Dedicated to the structure of DNA and the processes that propagate (??) ... are displaced by base-base interactions, which creates disorder/hydrophobicity ...

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Genes and Chromosomes PowerPoint PPT Presentation

Genes and Chromosomes - Central Dogma: DNA to RNA to Protein. ... Promotion of cruciform structures by DNA underwinding. Mechanism of Type I topoisomerase action ...

Central Dogma: DNA to RNA to Protein. ... Promotion of cruciform structures by DNA underwinding. Mechanism of Type I topoisomerase action ...

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DNA: Structure, Dynamics and Recognition PowerPoint PPT Presentation

DNA: Structure, Dynamics and Recognition - Bond vibrations 1 fs (10-15 s) Sugar repuckering 1 ps (10-12 s) DNA bending 1 ... DNA: global and local 3'3' stretching. TBP induced deformation. X-ray Model ...

Bond vibrations 1 fs (10-15 s) Sugar repuckering 1 ps (10-12 s) DNA bending 1 ... DNA: global and local 3'3' stretching. TBP induced deformation. X-ray Model ...

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Learning Objectives PowerPoint PPT Presentation

Learning Objectives - Title: PowerPoint Presentation Author: karlm Last modified by: Emaneini Created Date: 11/25/2002 2:35:13 AM Document presentation format: On-screen Show (4:3)

Title: PowerPoint Presentation Author: karlm Last modified by: Emaneini Created Date: 11/25/2002 2:35:13 AM Document presentation format: On-screen Show (4:3)

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All you need to know about Chemotherapy. PowerPoint PPT Presentation

All you need to know about Chemotherapy. - All you need to know about Chemotherapy. Lynne Cormode What is Chemotherapy? Systemic treatment against malignant cells to try and prevent growth, invasion ...

All you need to know about Chemotherapy. Lynne Cormode What is Chemotherapy? Systemic treatment against malignant cells to try and prevent growth, invasion ...

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truktra a Topolgia DNA PowerPoint PPT Presentation

truktra a Topolgia DNA - X-ray diffraction data showed that DNA has the form of a regular helix, making a ... introduce knots in DNA and can catenate two circular molecules so that they are ...

X-ray diffraction data showed that DNA has the form of a regular helix, making a ... introduce knots in DNA and can catenate two circular molecules so that they are ...

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ACKNOWLEDGMENTS PowerPoint PPT Presentation

ACKNOWLEDGMENTS - BCG would like to thank the Association of International Cancer Research for their ... containing a fused tricyclic aromatic moiety and a cationic carboxamide side ...

BCG would like to thank the Association of International Cancer Research for their ... containing a fused tricyclic aromatic moiety and a cationic carboxamide side ...

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Topoisomerases PowerPoint PPT Presentations