The Cell Cycle

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The Cell Cycle
Dpp
Vg
CycE
stg
2
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3
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Insulin receptor is required for growth
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dFOXO
6
Insulin receptor is required for cell growth
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dFOXO
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PTEN mutants grow bigger
PTEN
WT
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PTEN mutants have more PIP3
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PTEN loss growth of imaginal cells
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PTEN loss rescues InsR loss
InsR
InsR PTEN
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PTEN/PTEN AktPH / AktPH
WT
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dFOXO
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The Cell Cycle
Dpp Inr
CycE
stg
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The Cell Cycle
Wg
Dpp Myc Inr
CycE
stg
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Ras upregulates Myc and CycE postranscriptionally
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The Cell Cycle
Wg
Ras
Dpp Myc Inr
CycE
stg
Wg
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Nitric Oxide is expressed when division stops
time
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NO levels control cell division
wt
Green dividing cells
Low NO
High NO
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WT
Reduced NOS
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References

• Hafen (2004) Swiss Med Wkly 134 711-719 (review)
• And from Fridays Lecture
• Martin-Castellanos and Edgar (2002) Devedlopment
  129 1003-1013