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Picornaviruses Enteroviruses

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Picornaviruses. Enteroviruses. Molecular Classification of enteroviruses ... With the Polio MLV (Sabin Oral PV vaccine) significant disease can arise by back ... – PowerPoint PPT presentation

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Title: Picornaviruses Enteroviruses


1
PicornavirusesEnteroviruses
Molecular Classification of enteroviruses (by
genome sequence)
2
Genetic relatedness of Picornaviruses
3
Polio Eradication and Vaccination
Poliovirus disease 2006 Jan-May 06 452 Cases
Poliovirus disease 2007 Jan-May 07 183 Cases
4
VDPV Vaccine-derived Polio viruses
  • With the Polio MLV (Sabin Oral PV vaccine)
    significant disease can arise by back mutation in
    areas of low rates of vaccination Afganistan,
    Pakistan, India and Nigeria

5
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6
Recent data with Hepatovirus (Hep A) Vaccine
7
Recent data with Hepatovirus (Hep A) Vaccine
8
Genome organization Picorna- compared to Calici-
Picronaviridae
Caliciviridae
9
Genome organization Hepeviridae Hep E
Another viral gene Methyl Transferase
10
Hepatitis viruses
11
Togavirus Genomes
Review ns gene functions
12
Togaviruses
13
Arthropod-Borne virusesMosquito-borne
Vector Competence Sufficient virus is taken up
in a blood meal Virus Replicates
Virus is transmitted via Salivary Gland
14
An Example of an RNA virus Recombinant
WEE has ns genes from New world Alphaviruses,
but structural genes from old world
Alphaviruses
15
Gene Expression Glycoprotein Maturation Golgi
Proteases, Miristylation, Oligomerization,
Glycosylation
16
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17
Transmission Cycles The virus alternates between
insects and birds or insects and mammals
YF Yellow Fever Dengue Flaviviruses
An EEV Cycle, a Togavirus
18
The ARBOviruses of Toga- and Flaviviruses are
geographically delineated
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