Prsentation PowerPoint

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• Disturbances in Arterial Blood Gases Exchanges
  in Treated Asthmatic Patients.

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• Authors Ebrahim Razi, Gh.A. Moussavi
• Institution Kashan University of Medical
  Sciences, Kashan, Iran.

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• Introduction
• In asthma, arterial blood gases exchanges
  is a common findings, that hypoxemia is the most
  common form of it.
• The mechanism of hypoxemia is
  ventilation/perfusion mismatch.
• The incidence of hypoxemia in attack free
  asthmatic children is reported 71 (1).
• he mechanism of hypoxemia in asthmatic
  patients in remission period is related to
  hyperaeration and ventilation/perfusion mismatch
  (2).
• If hypoxemia does not manage exactly, it
  may to be leads to irreversible obstruction of
  airways and pulmonary hypertension.

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• Aim of study
• The aim of this study was evaluation of
  Arterial Blood Gases exchanges disturbances in
  referred acute asthmatic patients, seven days
  after treatment with anti-asthmatic drugs, and
  comparison the results with normal subjects.

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• Material Methods
• The study was carried out on 122 acute
  asthmatic patients (FEV1 lt 60 pred.).
• The results were compared with ABG of 121
  normal subjects.

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• The patients underwent with routine
  anti-asthmatic drugs for one week as
• Spray salbutamol 2 puffs QID
• Capsule Chromolyn Sodium TDS
• Tab. Prdnisone 1mg/kg/day
• All of the patients one week after treatment
  underwent spirometry and ABG analysis.

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• Results

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• Conclusions
• In treated asthmatic patients after 7 days of
  treatment, hypoxemia is a common complication,
  which necessitates further supervision and
  monitoring after the occurrence of acute
  asthmatic attacks.

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• References
• 1- Wolf B, et al. Hypoxemia in attack free
  asthmatic children relationship with lung volume
  s and lung mechanics. Bull Eur Physiopathol
  Respir 1988 19471
• 2- Palmer KNV, et al. Pulmonary function in
  asthmatic patients in remission. Br Med J 1975
  1 471

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• The Effect of Position on Spirometric Values in
  Obese Asthmatic Patients.

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• Authors Ebrahim Razi, GH.A. Moussavi
• Institution Kashan University of Medical
  Sciences, Kashan, Iran.

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• Introduction
• The obesity as a common health risk is increasing
  all over the world.
• In obese individuals the effects of increased
  abdominal fat tissue might be expected to
  increase the effects of body position on lung
  volume (decreased FRC)1.
• In normal obese individuals, body position
  reported that has not significant differences
  between sitting and standing position (2).
• In another study that was carried out in massive
  obese young adults, no differences from predicted
  vital capacity on change of position were seen
  (3).

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• Aim of study
• The aim of this study was to determine the
  effects of body position (standing vs sitting
  position), in obese asthmatic patients with
  compared to obese normal subjects.

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• Material Methods
• The study was conducted on
• 49 obese asthmatic patients,
• 51 obese normal subjects without asthma.
• Obesity was defined as BMI 30 kg/ m2

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• Spirometry was performed with Fukuda spirometer
  (ST 95), according to ERS recommendation.
• In both groups the spirometry was performed
  alternately in standing and sitting position.
• Comparison of mean values of the differences
  between two groups of subjects in sitting and
  standing position was determined, using
  Mann-Whitney test and paired t test.
• p value 5 was considered significant.

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• Calculation of change percent was down as below
  formula
• (Sitting value standing value) / sitting
  value 100

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• Conclusions
• Spirometric values in obese asthmatic patients
  with BMI 30 kg/ m2 in compared with normal
  obese subjects is not affected by the position.

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• References
• 1. Tucher, D. H., and H. O. Sieker. 1960. The
  effect of change in body position on lung volumes
  and intrapulmonary gas mixing in patients with
  obesity, heart failure and emphysema. Am. Rev.
  Respir. Dis. 1960 82 787
• 2- Gudmundsson G, et al.
• Spirometric values in obese individuals.
  Effects of body position.Am J Respir Crit Care
  Med. 1997 Sep 156(3 Pt 1)998.
• 3. Ray, C. S., et al. Effects of obesity on
  respiratory function. Am. Rev. Respir. Dis. 1983
  128 501

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