PowerPointPrsentation

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Glycine Free Amino Acid or Integrated into
Proteins Precursor Serine
Serine hydroxy-
methylase
(folate dependent)
Glycine
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Presynapse Serine
Glycine
(sotrage ???) ------------------------------------
------------------------------------ Synaptic
cleft Na-dependent
transporter --------------------------------------
----------------------------------
Glycine
A-receptor Postsynapse
ionotropic
Cl- channel, inhibitory

Glycine B-receptor
Gly binding site of
the NMDA
receptor
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Release inhibitor Tetanus toxin Agonists at the
Gly A-R Gly, beta-alanine, taurine Antagonists
strychnine picrotoxin (Cl- channel blocker)
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Agonists at the Gly B-R Gly binding site of
NMDA-R Gly, D-serine, HA 966 Gly transporter
inhibitors Under development Antagonists Dichloro
kynurenate MNQX
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Physiology Gly A-R Presynaptic inhibition Spinal
cord Feed-back-inhibition of motoneuron
activity Gating Habituation Inhibitory on brain
stem activity on ARAS In the retina Pathophysiolo
gy Reduced activity muscular convulsions
(for example strychnin
poisening) Enhanced activity inhibition of
motoneurons
inhibition of ARAS (narcosis)
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Glycinerig Renshaw neuron
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Anatomy Glycin-A-receptor Spinal cord
Renshaw-inhibition (only in vertebrates) Supraspi
nal brain stem retina
Glycin-B-receptor Corresponds to
the distribution of NMDA-receptors
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Physiology of Gly B-Receptor Allosteric
modulation of the NMDA receptor Pathophysiology
Enhanced activity Enhances affinity for
Glutamate and channel opening frequency. Facilitat
es learning Anti-schizophrenic ??? Reduced
activity Some simailarities with weak
NMDA-R-antagonists Psycic and motor
activation (in Alzheimers disease Gly-R density
is reduced)