Cochrane Collaboration

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Presentation Objectives

• Provide Overview of Cochrane Collaboration
• Demonstrate Cochrane Database of Systematic
  Reviews (CDSR)
• Invite Participation

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Cochrane Collaboration

• International non-profit organization that
  prepares, maintains, and disseminates systematic
  up-to-date reviews of health care interventions.

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Archie Cochrane

• It is surely a great criticism of our
  profession that we have not organized a critical
  summary, by specialty or subspecialty, adapted
  periodically, of all relevant randomized
  controlled trials.

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The Cochrane Collaboration
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Cochrane Collaboration Aims
Information that is

• Evidence-Based
• Easily Accessible
• Internationally Developed
• Quality Controlled
• Clinically Useful
• Periodically Updated

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Systematic Review

• Structured process involving several steps
• Well Formulated Question
• Comprehensive Data Search
• Unbiased Selection and Abstraction Process
• Critical Appraisal of Data
• Synthesis of Data

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Cochrane Collaboration
Review Groups
Centres
Steering Group
Methods Groups
Fields
Consumer Network
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Cochrane Collaboration
Review Groups
Centers
Steering Group
Methods Groups
Fields
Consumer Network
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Cochrane Centres
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Cochrane Centres

• Help Organize and Register Review Groups
• Facilitate Collaboration Among Reviewers
• Provide Training and Consultation
• Establish Liaisons
• Promote Cochrane Collaboration
• Provide Unique Contribution

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Cochrane Centres Unique Contributions

• Australasian Internal Communications
• Brazilian
• Canadian Internet Communication
• Chinese
• Dutch Placebo-Effects
• French Registry
• German
• Italian Dissemination and Media

• Nordic Methodology
• New EnglandStatistical MethodsResearch/Software
  DevelopmentRCT Searching/Registry
• South African
• San Antonio Training
• San Francisco Quality Control
• Spanish
• United Kingdom Database of
  Reviews

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Cochrane Collaboration
Review Groups
Centers
Steering Group
Methods Groups
Fields
Consumer Network
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Review Groups45 Registered, 3 Possible

• Focus
• Treatment of Disease or Health Problems
• Emphasis on Clinical Outcomes
• Emphasis on Rigorous Data

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Registered Review Groups include

• Neonatal
• Oral Health
• Infectious Diseases
• Pregnancy Childbirth
• Schizophrenia
• Stroke
• Tobacco Addiction
• Wounds

• Acute Respiratory Infections
• Breast cancer
• Dementia Cognitive Impairment
• Diabetes
• Effective Practice and Organisation of Care
• Muskuloskeletal

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Review Group Products

• Reviews
• Specialized Registry

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Review Groups

• Reviewers
• International Group
• Review Relevant Trials on Specified Health
  Care Problems
• Long-term Commitment

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Collaborative Review Group Process
Systematic Reviewer
Systematic Reviewer
Systematic Reviewer
Editors
Coordinator
Systematic Reviewer
Systematic Reviewer
Cochrane Database of Systematic Reviews
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Review Manager (RevMan)

• Cochrane Collaboration Software For
• Submitting Review Protocol
• Entry of Data For Analysis
• Publishing Completed Reviews on CDSR

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RevMan Statistical Options

• Peto Method
• Odds Ratio
• Mantel-Haenzel Fixed Effect and
  Dersimonian/Laird Random Effects
• Odds Ratio, Relative Risk, Risk Difference
• Weighted and Standardized Mean Differences

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The Cochrane LibraryIssue 1/99 January
1999CDROM and Internet

• Cochrane Systematic Reviews (522 Reviews, 492
  Protocols)
• Abstracts of Reviews of Effectiveness -York CRD
  (1895 items)
• Review Methodology Database (866)
• Cochrane Controlled Trials Register (218,355
  items)

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Cochrane Collaboration
Review Groups
Centers
Steering Group
Methods Groups
Fields
Consumer Network
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Fields7 Registered, 2 Possible

• Represent a population, group, or type of care
  that overlaps multiple Review Group areas
• Examples Primary Care, Elderly, Complementary
  Medicine

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Methods Groups9 Registered, 7 Possible

• Develop methods and products integral for
  internal functioning of Collaboration
• Develop state of the art methods for systematic
  reviews
• Examples Informatics, Statistics, Coding and
  Classification

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Consumer Network

• Provides Consumer Input
• Helps Set Priorities
• Helps With Dissemination

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Cochrane Collaboration
Review Groups
Centers
Steering Group
Methods Groups
Fields
Consumer Network
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Steering Group

• Function
• Policy making body of Cochrane Collaboration
  
• Who
• Elected representatives of each of the
  Collaboration entities (e.g. Review Groups,
  Centers, Etc.)

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Summary of Cochrane Collaboration

• International Collaboration
• Prepares, Maintains, Disseminates Systematic
  Reviews
• Diverse Internal Structure (Review Groups,
  Centers, Fields, Methods, Consumers)

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How to Participate

• Establish or Join a Collaborative Review Group
• Join a Field, Methods Group, or Consumer Network
• Hand search a Journal
• Identify or Provide Funding

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Future Challenges

• Recruitment of large numbers of reviewers in all
  areas of Health Care
• Clinically useful presentation of the Database
  of Systematic Reviews
• Efficient and effective communication within
  the Collaboration
• Financial solvency of the organization

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Cochrane Collaboration
For More Information on the Cochrane Collaboration

• Contact your nearest Cochrane Center
• Web page http//www.cochrane.org

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The Cochrane Collaboration
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