Developmental Bio

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Anabolic Steroids
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Anabolic Steroids

• Synthetic molecules created with the goal of
  creating a complete separation of androgenic and
  myotropic (anabolic) activities
• Androgenic activity characterized by effects on
  prostate and seminal vesicles
• Myotropic effects characterized by effects on
  levator ani muscle

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Physiological dose ?
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Side Effects of Anabolic Steroids

• Virilizing side effects
• Prepubertal Masculization of fetus
  (pseudohermaphrodism), premature epiphyseal
  closure
• Men LH FSH ?, testes size ?, sperm prodn.? ,
  sterility
• Women hirsutism, acne, deepened voice,
  hypertrophy of clitoris, male pattern baldness

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Side Effects of Anabolic Steroids

• Feminizing Side Effects in Males
• Gynecomastia
• Possible mechanism metabolism of anabolic to
  estrogenic compound (the compound you take isnt
  necessarily the one that ends up at the target
  tissue)
• Other Possible Side Effects
• ? HDL ? LDL (severe),? blood pressure,
  cardiovascular disease, Aggression?
• Jaundice, Gallstones, Peliosis hepatitis (blood
  filled cysts in the liver), Hepatoma (benign or
  malignant), Prostatic hypertrophy (benign or
  malignant)

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600 mg testosterone enanthate i.m./week x 10 weeks
600 mg testosterone enanthate i.m./week x 10 weeks
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600 mg testosterone enanthate i.m./week x 10
weeks
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New England J. of Med. Vol. 335
600 mg testosterone enanthate i.m./week x 10 weeks
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Plt 0.05
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