Surface Concentration of Antimicrobial Function

1
Surface Concentration of Antimicrobial Function
Kenneth J. Wynne, Virginia Commonwealth
University, DMR 0207560
Polymer Surface Modifier
A
B
A
B
PAB
Bulk polyurethane

• Fluorous side chain A surface-concentrates
  biocidal C-12 alkylammonium B (n 0.11)
• Only 2wt PAB polyurethane modifier effects
  complete kill in 30 min of aerosol spray of E.
  coli, S. aureus, and P. aeruginosa
• Potential applications catheters, gloves

Complete kill on 2wt modified polyurethane
Control 464 colonies P. aeruginosa

• Collaborative, interdisciplinary research Grad
  student, Pinar Kurt (CLSE) Drs. D. Ohman, Lynn
  Wood, VCU School of Medicine, Department of
  Microbiology and Immunology
• Kurt, P. Wood, L. Ohman, D. E. Wynne, K. J.,
  Langmuir (Letter) 23(9) 4719-4723, 2007.

2
Functional Polymer Surfaces
Kenneth J. Wynne, Virginia Commonwealth
University, DMR 0207560

• Outreach
• Collaborative international training for
  graduate students from Kyoto Univ. (Prof. Chujo)
  and Univ. of Pisa (Prof. Chiellini and Prof.
  Galli).
• Collaborative international training in surface
  science for undergrads from Koç Univ. (Prof.
  Yilgor)
• Panel member, May 07, NSF STC Center on
  Materials and Devices for Information Technology
  Research, University of Washington, Seattle
• Co-Organizer, K-12 Workshop / Symposium Polymer
  Science of Everyday Things, Boston ACS, August
  07.

• Education
• Two Ph.D.s Dr. Janelle Uilk (Phillip Morris)
  and Dr. Umit Makal (Novion)
• One post-doctoral Professor Tomoko Fujiwara (U.
  Memphis)
• REU undergrads 06 Ms. R. Wickham (Grad School
  U. Md, Fall 07).
• Three Ph.D. graduate students are being trained
  Ms. Pinar Kurt (4th yr), Ms. Allison Mullins (3rd
  yr and Mr. Kennard Brunson (2nd yr).
• Grad course development Polymers in Medicine