Progesterone during pregnancy and repeat breedingembryonic death

1
Progesterone during pregnancy and repeat
breeding/embryonic death
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Corpus luteum
Follicle
Pregnancy
Embryonic death
Progesterone
17 days
Irregular return to heat
42 days
Heat, insemination
Return after 21 days
2
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• CVM, DUMS,1/29 translocation, STAT5A mutation.
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• Bacteria, virus, fungus, protozoa (Neospora
  caninum)
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• ??- ?????
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3
Example of a gene causing embryonic death or
pregnancy loss. Trial in American Holstein with
DUMS (Deficiency of uridine monophosphate
synthase)
9 homozyg.normal
0 homozyg. abnormal born
14 heterozyg.

• After Shanks and Robinson, 1989

4
Spreading of mutations - illustration
5
The origin of CVM
PENSTATE IVANHOE STAR Born 1963
Carlin-M Ivanhoe Bell
6
Progesterone during pregnancy and repeat
breeding/embryonic death
Corpus luteum
Follicle
Pregnancy
Embryonic death
Progesterone
17 days
Irregular return to heat
42 days
Heat, insemination
Return after 21 days
7
Embryonic lethality related to prevalence of
deleterious alleles in a population
Carriers