Winthrop University Nov '05 SC EAS INBRE Presentation

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Winthrop INBRE Update Presented to
SC-INBRE External Advisory Committee November
2005
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CHE Research Performance Data for South Carolina
State Teaching Universities

• Teaching University FY03-04 Sponsored
  Research
• S.C. State Univ. 3,470,643
• College of Charleston 3,418,957
• Coastal Carolina Univ. 1,382,317
• U.S.C. Aiken 699,707
• Francis Marion Univ. 284,113
• U.S.C. Upstate 220,597
• Winthrop University 217,617
• Citadel 101,570
• Lander Univ. 11,713
• U.S.C. Beaufort 7,613
• Total 9,814,840
• based upon CHE Step 2 Research numbers
  (representing 30 of FY 03-04 sponsored research
  expenditures) obtained from http//www.che.sc.gov/
  Finance/Fin/MRRManual/MRR_Booklet05-06_II.pdf,
  accessed Nov 20, 2005.

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Defining The Winthrop ExperienceWhat We
Promise Students and Families

• As a predominantly residential learning
  university, Winthrop focuses on fully engaging
  students in developing the capacity to become
  leaders in their professions and leaders in their
  communities. Over their years of undergraduate
  study, Winthrop students have the opportunity to
  participate in a highly personalized, engaging
  and progressively developmental series of
  experiences that will build within them the
  capacity to read, write and think about
  themselves and the world around them in ever more
  meaningful and purpose-driven ways, both
  personally and professionally.
• Slide from President DiGiorgios Education by
  Design April 2005 Presentation to Winthrop

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Defining The Winthrop ExperienceWhat We
Promise Students and Families

• At Winthrop, a high-achieving, diverse
  student body interacts with talented,
  national-caliber faculty and staff in ways
  intentionally designed to prompt thought,
  reflection and a life-long quest for knowledge
  and understanding. Conversations that begin in
  classrooms extend across the campus community,
  complemented by an extraordinary range of
  cultural events, service-learning activities,
  guided research and other transformational
  opportunities.
• That is The Winthrop Experience.
• Slide from President DiGiorgios Education by
  Design April 2005 Presentation to Winthrop

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Winthrops INBRE Objectives

• Dramatically expand biomedical research capacity
• 2) Increase the competitiveness of faculty for
  external biomedical research funding
• 3) Establish a strong biomedical research
  infrastructure core
• 4) Provide students with a strong
  interdisciplinary foundation in the biomedical
  sciences
• 5) Increase the number and the percentage of
  biology and chemistry graduates that enter
  biomedical research fields
• 6) Recruit, train, and mentor students from
  underrepresented groups to increase the number
  and the percentage of female and minority
  graduates that pursue biomedical research

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Winthrop University Organization

• President (Dr. Anthony J. DiGiorgio)
• VP for Academic Affairs (Dr. Moore) INBRE
  Steering Committee ex-officio nonvoting member
• Dean, College of Arts and Sciences (Dr. Boyd)
  INBRE Steering Committee ex-officio nonvoting
  member
• Chairs, Departments of Biology (Johnston)
  Chemistry (Owens) Winthrop INBRE Project
  Co-Directors
• Chemistry Faculty (Lammi, Parker, and Sumter-
  INBRE Investigators Calloway INBRE Core Lab
  Director)
• Biology Faculty (Dimaculangan, Glasscock, and
  Westover- INBRE Investigators)

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The Winthrop INBRE Experience

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Winthrop Steering Committee (Meeting Dates of
Sep 9, 2004 Dec 2, 2005)

• Ralph Meyer Director, Biology Division,
  Orthopaedic Research Laboratory,Carolinas Medical
  Center,Charlotte, NC
• Frank Berger Director, Center for Colon Cancer
  Research and Professor, Department of Biological
  Sciences, USC
• Merle Schuh Councilor, Council of Undergraduate
  Research and Professor of Chemistry, Davidson
  College
• Gary Schwartz Scientific Director, Prostate
  Cancer Center for Excellence, Comprehensive
  Cancer Center of Wake Forest University, Winston
  Salem, NC
• Debra Boyd (ex-officio nonvoting member) Dean of
  the College of Arts and Sciences, Winthrop
  University
• Tom Moore (ex-officio nonvoting member)
  Vice-President for Academic Affairs, Winthrop
  University

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Project Investigators (Mentors)

• Dwight Dimaculangan (Carver - USC)
• Stem Cell-Augmented Repair in a Bioengineered
  Cardiac Model
• Laura Glasscock (Church UNC,Teigland - CMC)
• The Role of Thrombomodulin in Prostate
  Cancer-Associated Angiogenesis
• Robin Lammi (Dawson - USC, Holten - Wash U)
• Monitoring Metal-Ion Concentration and
  Metal-Induced Conformational Change at the Level
  of Single Ions and Enzymes
• Chasta Parker (Sodetz USC, Lebioda - USC)
• Structural Studies of a Recombinant Membrane
  Interacting Region of Complement Component C8a
  and Adiponectin Membrane Receptor 1
• Takita Sumter (F. Berger - USC)
• Functional Mapping of High Mobility Group A1
  (HMGA1) Binding Domains Required for Tumor
  Transformation
• Kristi Westover (Hughes - USC)
• Hepatitis B Virus Adaptive Evolution of Immune
  Recognition and Evasion

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Core INBRE Lab Director Four Scientists

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Infrastructure Objectives Progress

• Procure 100K of biomedical research equipment
  Planning completed and quotes obtained in June,
  orders delayed until August 17, 2005, 117K now
  on order, 2/3 of equipment now at Winthrop
• Install cold room - Ordered and partially
  installed, several parts on backorder, Jan 2006
  expected operational date
• Make necessary facility modifications and equip
  offices for staff scientists Classroom being
  converted (Dec 05 completion), office furniture
  ordered, completion in Jan 06.
• Complete four staff scientist searches - All four
  ongoing
• Two MS Scientists (12 month Research Staff
  Scientist positions, 100 Core time) interviews
  to be conducted soon (Feb 1, 2006 start)
• Two Ph.D. Scientists (9 month Assistant
  Professor of Biology (Chemistry) positions, 50
  core time) Aug 15, 2006 start

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Faculty Development Objectives Progress

• AY06-07 Three Faculty submit research proposals
  AY07-08 and all succeeding years Six biomedical
  research proposals submitted annually
• 165K proposal submitted to NSF RIG program in
  July 2005 by Takita Sumter (PI)
• AY 04-05 Four staff scientist positions
  approved. AY 05-06 Laboratory chemist position
  approved. AY 05-06 Obtain FTE approval for two
  regenerative medicine faculty positions.
• Four Staff Scientist INBRE FTEs submitted by
  Winthrop to South Carolina during AY04-05 were
  disapproved by the State.
• Renewed requests for these four and the remaining
  additional three FTEs have been submitted to the
  Dean for inclusion within Winthrops AY05-06
  request to State.

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Student Development Objectives Progress

• AY 09-10 At least 20 students engaged in
  biomedical research projects
• Summer 2005 12 Students engaged in biomedical
  research, half supported by Winthrop Research
  Council Funds. September 9, 2005 poster session.
• Fall 2005 13 Students engaged in biomedical
  research
• AY 09-10 20 students make conference
  presentations and five students are co-authors on
  peer-reviewed publications from biomedical
  research
• Three student presentations at national
  conferences in AY04-05, six at SCAS in Mar 05
• Three abstracts submitted for spring 2006
  national ACS meeting two abstracts for 2006
  ASBMB submitted, multiple NCUR submissions being
  prepared.
• AY 05-06 Develop a formal recruitment plan. A
  recruitment plan will be developed after the
  initial advisory committee meeting in December
• AY 04-05 Continue discussions and review similar
  programs being implemented. AY 05-06 Develop
  integrated biomedical science curriculum. AY
  06-07 Gain curricula approval for biomedical
  program
• Discussions on the biomedical curriculum will be
  a focus after the advisory committee meeting in
  December 2005. ASBMB and BIO2010 recommendations
  being examined

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Summary of Budget Changes

• 11,916 Balance from Summer Salaries
• Balance due to separate student funding from
  May 15- June 30, INBRE start date of July 1,
  2005, and one Project Investigators maternity
  leave
• These funds being reallocated for equipment
  upgrade (centrifuge accessories), for critical
  supplies, for a spring graduate student stipend,
  and for undergraduate research assistantships
• 3,000 mentor and advisor travel expense budget
  allocation to also be used to cover Winthrop
  Steering Committee meeting Dec 2, 2005

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Investigator-Mentor Interactions and Progress of
Research

• Mentor-Investigator Interactions
• All six projects interacting with mentors through
  emails phone calls
• Four mentor visits to Winthrop Dawson (2),
  Sodetz, and Berger
• Many investigators have made multiple visits to
  mentor sites Parker USC, Dimaculangan USC,
  Sumter USC, Glasscock CMC, Lammi Wash U (Jan
  06), Westover USC
• Project progress reports all providing evidence
  of active mentorship
• Research Progress Lessons Learned to Date
• Investigator time is a critical commodity
• At risk ordering is a must, shift procurement
  burden from investigators
• Need for staff scientist core support
• Increased availability of Core Lab Director
  during summer
• Service contracts on critical equipment items
• Need to replace obsolete equipment to improve
  research productivity
• Need for improved communications with facilities
  management

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Equipment Infrastructure Continuous Modernization
Plan

• Funds Required to Sustain Equipment
  Infrastructure
• Annual funds to operate and maintain
• Annual funds to update and upgrade
• Annual funds for service and repair
• Capital funds for replacement when obsolete
• Capital funds for new technologies
• Possible Sources of Equipment Funds
• Increased operating budgets (University equipment
  fees)
• Winthrop Foundation equipment endowment and grant
  match accounts
• Faculty development of external equipment grants
• Reinvestment of indirect costs from external
  grants
• Increased student laboratory fees
• User fees from local industry
• Revenues from summer school
• Supplemental State allocations for science
  equipment