Innate Immunity

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Type of Immunity
Innate Immunity Adaptive Immunity(acquired) Cel
l Mediated Immunity (CMI) Humoral Mediated
Immunity (HMI)
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Innate immunity(cells)

• Phagocytosis
• Natural killer cell

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Phagocytosis

• Attachment
• Ingestion
• Digestion

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Innate immunity(humoral)

• Complement system (C1-C9)
• Lysozyme
• Interferon
• Acute phase proteins
• etc.

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Type of Immunity
Innate Immunity Adaptive Immunity(Acquired)
Humoral Mediated Immunity (HMI) Antigen,
Antibody Cell Mediated Immunity (CMI) T-cell
receptor, Cytokines
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Properties of Antigen

• Foreigness
• MW gt1000
• Complexity

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Epitope (Antigenic determinant)

• ??????????????????????????????????
  ?????????????????????????????? 500-700 daltons
  ????????
• ?????????????????????????????????????
• ??????????????????????????????? epitope
  ???????????

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http//www.niaid.nih.gov/daids/vaccine/gp120.htmD
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Type of Antigen

• T-dependent Ag
• T-independent Ag

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Hapten

• Small( MWlt 500 )
• no immune response
• specificity of antigen-antibody reactions

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Comparison between Innate and Adaptive Immunity
Innate Adaptive
Response time Immidiately 7-14 Specificity No
Yes Memory No Yes