rhodos vortrag

1
Inflammation and nose
2
Exposure group Bitumen workers
3
Reference group outdoor construction workers
4
Characteristics of the study population
High exposure
Low exposure
High exposure
Low exposure
References
Exposed (total)
References
Exposed (total)
gt10 mg/m
?10 mg/m
?10 mg/m
?10 mg/m
3
3
3
3
Attribute
Attribute
n55
n30
n172
n202
n55
n30
n172
n202
Exposure to fumes
Exposure to fumes of
and aerosols of
16.7
(10.2
-
41.7)
3.0 (0.1
-
9.8)
3.7 (0.1
-
41.7)
16.7
(10.2
-
41.7)
3.0 (0.1
-
9.8)
3.7 (0.1
-
41.7)
bitumen (mg/m
3
)
bitumen (mg/m
3
)
?
-
(median range)
(median range)
Age (years)
Age (years)
37 (19
-
61)
40.5 (17
-
52)
40 (18
-
63)
40 (17
-
63)
37 (19
-
61)
40.5 (17
-
52)
40 (18
-
63)
40 (17
-
63)
(median range)
(median range)
Current smoking
Current smoking
23 (
41.8
)
20 (66.7)
113 (65.7)
132 (
65.7
)
23 (
41.8
)
20 (66.7)
113 (65.7)
132 (
65.7
)
n ()
n ()
German nationality
German nationality
48 (
87.3
)
15 (50.0)
121 (70.8)
136 (
67.7
)
48 (
87.3
)
15 (50.0)
121 (70.8)
136 (
67.7
)
n ()
n ()
Duration of work in
Duration of work in
the current
the current
company (years)
company (years)
6.5 (3
-
10)
6.5 (2
-
16)
8 (3
-
14)
8 (3
-
14
)
6.5 (3
-
10)
6.5 (2
-
16)
8 (3
-
14)
8 (3
-
14
)
(median
(median
interquartile range)
interquartile range)
5
Collection of nasal lavage fluids (NALF)

Analysis cellular and humoral parameters
(e.g. IL-8, IL-1b, TNF-a, IL-6, NO, albumin)


6
Neutrophils in NALF pre-/post-shift-compari
son in the three exposure groups
60
55
50
45
p0.023
p0.010
40
Neutrophils in NALF
35
p0.020
p0.0002
30
25
20
15
pre-shift
post-shift
reference group
low exposure group
high exposure group
7
IL-8-determination in NALF
pre-/post-shift-comparison in the three exposure
groups
350
300
250
200
n.s.
IL-8-concentration in NALF pg/ml
150
n.s.
100
50
0
pre-shift
post-shift
reference group
low exposure group
high exposure group
8
Conclusion NALF

• Small increase of neutrophils after high airborne
  bitumen exposure during shift in nasal lavage
• Although no direct comparison was made,
  irritative effects can possibly be differentiated
  from allergic effects