Chem 356 Examples from bioinorganic chemistry

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Chem 356Examples from bioinorganic chemistry
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Oxygen transport systems
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myoglobin
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Hemoglobin
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Iron heme
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Hemoglobin
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Hemoglobin and oxyhemoglobin
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Modes of O2 binding
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Small molecule studies
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High and low spin complexes
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Modes of O2 binding
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Change in conformation with O2 binding
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O2 and CO binding
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Carboxypeptidase A
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Carboxypeptidase Amechanism
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• Carboxypeptidase mechanism

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Mechanism of CPA
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CPA with bound inhibitor
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Two inhibitors of carboxypeptidase
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pH dependence of rate of hydrolysis
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UV-Vis spectra of Co2 model complexes (of CPA)
Tetrahedral Co2 in Co(NCS)42-
Octahedral Co2 in Co(en)32
TBP Co2 in CoBr(hexamethyl-diethylenetriamine)
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Calmodulin
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EF-hand domain
Seven-coordinate Ca2 ion (O-atoms donated from
amino acid side chains)
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Ca2-binding loops in a pair of EF-hand domains
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Sequences of parvalbumin and calmodulin (two Ca2
binding proteins)
Side chains bond to Ca2 via sidechain alcohol,
carboxylate, or carboxamide oxygens or via
backbone carbonyl oxygens
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Calmodulin-peptide complex