BDNF

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BDNF

• Brain-derived neurotrophic factor (BDNF) is a
  25-kDa CNS protein implicated in neuronal cell
  growth and differentiation

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5-HT and BDNF-regulated intracellular signal
tranduction pathways
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A model for antidepressant treatment
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• BDNF gene in mice has 6 upstream exons and 1
  coding sequence? 9 different BDNF isoforms
  produced by alternative splicing
• Splice variants thought to contain different
  promoter sequences which respond to temporal,
  spatial and biochemical cues