Type III secretion Marcia B. Goldberg

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Type III secretionMarcia B. Goldberg
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Salmonella infection
Galan JE, et al.
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Time course of Salmonella infection
Van Engelenburg SB and Palmer AE, Chem Biol
15619, 2008
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Salmonoella SopE is a guanine nucleotide exchange
factor (GEF)
Buchwald G et al. EMBO J 213286, 2002
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Salmonoella SopE is a guanine nucleotide exchange
factor (GEF)
Buchwald G et al. EMBO J 213286, 2002
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Salmonella SipA induces actin polymerization
Actin, high salt
Actin, SipA, low salt
Actin, SipA, high salt
Galkin VE et al. Nat Struct Biol 9518, 2002
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Salmonella SipA stabilizes actin filaments
Galkin VE et al. Nat Struct Biol 9518, 2002
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Salmonella SipA is structurally similar to nebulin
Galkin VE et al. Nat Struct Biol 9518, 2002
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Salmonella SptP is a two-domain protein
Stebbens CE and Galan JE, Mol Cell 61449, 2000
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Salmonella SptP GAP domain interacts with the
Rac1 switch I and switch II regions
Stebbens CE and Galan JE, Mol Cell 61449, 2000
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Salmonella SptP is structurally dissimilar from
other GAPs
Stebbens CE and Galan JE, Mol Cell 61449, 2000
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Salmonella SptP PTP domain is similar to Yersinia
YopH and eukaryotic PTP1B
Stebbens CE and Galan JE, Mol Cell 61449, 2000
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Salmonella SptP dephosphorylates VCP, a AAA
ATPase facilitator of cellular membrane fusion
Humphreys D et al, Cell Host Microbe 5225, 2009
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Salmonella induces endosomal tubulation
Garcia-del Portillo F, et al. PNAS 9010544,
1993 Mills SD et al, Infect Immun 661806, 1998
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Salmonella SifA and SseJ are sufficient to induce
endosomal tubulation
Ohlson MB et al, Cell Host Microbe 4434, 2008
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Endosomal tubulation requires microtubules, and
SKIP
Ohlson MB et al, Cell Host Microbe 4434, 2008
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Salmonella SifA is structurally similar to SopE
Ohlson MB et al, Cell Host Microbe 4434, 2008
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Model for generation of Salmonella endosomal
tubules
Ohlson MB et al, Cell Host Microbe 4434, 2008
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Differential secretion of Salmonella SopE2 and
SptP into host cells
Control bacterium
SopE2
SptP
Van Engelenburg SB and Palmer AE, Chem Biol
15619, 2008
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Differential stability of Salmonella SopE2 and
SptP inside host cells
Van Engelenburg SB and Palmer AE, Chem Biol
15619, 2008