INSTITUTE OF TOXICOLOGY

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INSTITUTE OF TOXICOLOGY

• 1, Bekhtereva str,
• Saint-Petersburg, 192019
• Tel. [phone]
• Fax [phone]
• drugs_at_mail.lanck.net
• Director Alexander N. Petrov,
• M.D., Ph.D.

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HISTORY OF THE INSTITUTE

• Institute of Toxicology was founded in 1935 under
  the name Leningrad Institute of Sanitation and
  Chemistry. The main goal of the foundation was to
  create the Research Center for the prophylaxis
  and treatment of acute poisoning by highly toxic
  chemicals. The Institute of Sanitation and
  Chemistry also became the teaching center in the
  field of toxicology. In 1958 it was renamed into
  the Institute of Toxicology. Since that time it
  has become a leading Center in the field of
  toxicological research. The founders of the
  Institute of Toxicology were outstanding Russian
  scientists - toxicologists and pharmacologists
  Academicians Sergey V. Anichkov, Nikolai N.
  Savitsky, Vladimir M. Karasik, Sergey N. Golikov,
  and Professors Sergey S. Vail, Alexander A.
  Likchachev, Vladimir I. Rosengart, Sergey G.
  Kyznetzov, Sergey S. Krilov. .

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ORGANIZATION STRUCTURE

• Within the structure of the Institute of
  Toxicology there are research laboratories,
  out-patient toxicological consulting clinic,
  toxicological safety centers and administration
  facilities
• Research laboratories
• Laboratory of Clinical Toxicology
• Laboratory of Chemical and Toxicological
  Diagnostics
• Laboratory of Psychopharmacology
• Laboratory of Applied Toxicology and Pharmacology
• Biochemical Laboratory
• Laboratory of Drug Toxicology
• Chemical and Pharmaceutical Laboratory
• Laboratory of Toxicology
• Laboratory of Biochemical Pharmacology
• Out-patient Toxicological Clinic
• Division of Pediatric Toxicology
• Division of Adult Toxicology
• Laboratory of Analytical Toxicology

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• Among 109 research workers of the Institute
• 18 PhDs
• 46 Candidates

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Main areas of research

• Experimental toxicology
• Pharmacology
• Ecology

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Specific areas of research
UNIQUE FACILITIES

• Toxicology of xenobiotics
• Analytical toxicology
• Elaboration of antidotes for treatment of
  poisonings
• Chemistry and technology of antidotes
• Pre-clinical trial testing
• Early diagnosis and prophylaxis of toxic effects
  of
• ecopollutants

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Preclinical testing

• Preclinical (acute, subacute and chronic
  toxicity) safety
• Biopharmaceutical analysis
• Bioavailability
• Bioequivalence
• Pharmacokinetic studies
• Specific pharmacology activity study

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Toxicity study

• Acute Toxicity DL(DL50, DL16, DL84) and others
  parameters
• Chronic toxicity weight, behaviour, food and
  water consumption, biochemical, physiological,
  pathomorphological, histological, haematological
  parameters___________________________________
• Toxicity of drugs, alcohols, mushrooms,
  industrial chemicals , heavy metals, pesticides
  is studied .

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Toxicity study

• Objects of studies
• Laboratorial animals mice, rats, rabbits,
  guinea-pigs, cats, dogs
• Cell cultures - bovine spermatozoids- daphnias
• Administration
• Per os
• Epidermic application
• Parenteral administration
• Inhalation

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Biopharmaceuticals Analysis Bioavailability,
Bioequivalence, Pharmacokinetic Studies in Humans
and Animals
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Regulatory standards

• Guidelines for experimental research of new
  pharmacological substances (Ministry of Health,
  Pharmacological Committee, Moscow, 2000)
• Complex comprehensive toxicological assessment
  of alcohol beverages safety (State Sanitary
  Epidemiological Inspectorate, Ministry of Health,
  , Moscow, 2002)

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INTERNATIONAL COLLABORATION

• Institute of Toxicology participates in
  international partner ISTC projects

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OUR COLLABORATIVE PROJECTS

• Project ?2951. Antidotes to highly toxic
  organophosphates. Project Duration - 6 month
• Workshop Agreement No. Us Ws02-03-sb47 Antidotes
  To Highly Toxic Chemical Substances Project
  Duration - 9 month
• Collaborators
• InstitutionPublic Health Emergency Preparedness,
  Department of Health and Human Services
• Partners
• InstitutionHHS Biotechnology Engagement Program
  (BTEP), the Office of Global Health Affairs/the
  Office for Eurasia

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Explanation of technical and research areas

• Pre-clinical study of new drugs and generics
  (total toxicity assessment, biopharmaceutical
  analysis, specific pharmacological activity
  assessment)
• Investigations in the field of chemical
  technology, physical chemistry as well as
  pharmaceutical and bioorganic analysis required
  for development of new drugs
• Toxicological testing of chemical compounds
  including industrial chemicals, pesticides,
  drugs, food and alcohol beverages