Lacie Smith

1
Can we fix it! Yes we can!

• Synthesis of Novel Quorum Sensing molecules

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Bacteria

• What are bacteria?
• How do bacteria communicate with one another?
• Quorum sensing

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Research Questions

• By making new signaling molecules which resemble
  the bacterial signaling molecule
• Will we be able to interfere with the bacterial
  communication?
• Will a damaging agent attach to the signaling
  molecules so that the bacteria cells will be
  killed?

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Goal

• To make several similar compounds with a
  variation in R group

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Methods

• Overall
• Scheme

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Why is this project important?

• Would benefit the medical, sewage, and marine
  environment
• Would offer a new approach in fighting infections

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References

• Bassler Bonnie How bacteria talk to each other
  regulation of gene expression by quorum sensing,
  Microbiology 1999, 2582-587.
• Brelles-Marino G Bedmar E. Journal of
  Biotechnology 91 2001, 197-209
• March J, Bentley W Quorum sensing and bacterial
  cross-talk in biotechnology. Biotechnology
  2004,15495-502.