Sin ttulo de diapositiva

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The perception of the Instituto de Medicina
Tropical Alexander von Humboldt The
integration of epidemiological, clinical and
laboratory research is a requisite for the
comprehensive understanding of the disease
phenomenon.
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-1- DGIS Major Goal Institutional strengthening
of the Instituto de Medicina Tropical Alexander
von Humboldt (IMTAvH) of the Universidad Peruana
Cayetano Heredia through the improvement of human
resources and research capabilities to work on
endemic diseases that are major public health
problems.
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Chosen Strategy The DGIS project has evolved
using a flexible framework that adapted the
material resources to the needs of each
component. Such flexibility allowed to tailor
the training platforms and to refine the
scientific progress according to maturation of
each component. The following aspects were
followed
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To conduct specific collaborative research
projects between partners of the IMTAvH and the
Prince Leopold Institute of Tropical Medicine
(IMT). The targeted health problems were
leishmaniasis, malnutrition, mycosis and
tuberculosis. These projects involve the
participation of young Peruvian scientists who
later on might be incorporated into the IMTAvH
research staff.
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To build up an intramural multidisciplinary
research team at the IMTAvH, with the capability
to study relevant infectious diseases using
diverse and complementary approaches. To
create physical core facilities to carry out
molecular biology procedures and for the
cryobanking of valuable biomedical material
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DGIS antecedents and evolution A general
Agreement was signed by the IMTAvH and the IMT in
the mid 80s (H. Guerra and Luc Eyckmans). In
1988 started a collaborative research between the
Molecular and Cellular Biology of Trypanosomatids
from the IMTAvH and the Protozoology group from
the IMT. This is one of the more long lasting
and fruitful collaborations between Belgian and
Peruvian partners that it is still ongoing.
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In 1990 Jean Claude Dujardin came to the IMTAvH
to pursue part of his PhD studies. In 1998
Kathleen Victoir came for the same purpose. In
1996 the inter institutional agreement was
renewed (E. Gotuzzo and B. Gryseels).
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In 1998 started current project when a contract
was signed within the DGIC/ ITMA Framework
Agreement. At the beginning it comprised four
different fields Parasitology, Nutrition,
Mycology and Bacteriology. A new component, the
Clinical one, was incorporated in year 2000.
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• Research Topics and their Leaders
• Clinical epidemiology and clinical trials
  (E. Gotuzzo, B. Gryseels, T. Verdonck)
• Malnutrition and micronutrient deficiencies
  (I. Pecho, Ana Prada, P. Kolsteren)
• Mycoses (B. Bustamante, D. Swinne)
• Tegumentary leishmaniasis (J. Arevalo,
  J.C. Dujardin, D. Le Ray)
• Tuberculosis and Buruli ulcer (H. Guerra,
  F. Portaels)

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• Remarkable aspects of each component
• Clinical epidemiology and clinical trials its
  agglutination role on the other components
  devoted to infectious agents the onset of HIV
  co-infection studies the translation into
  Spanish of the CDRom on tropical diseases, edited
  by IMT.

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• Malnutrition and micronutrient deficiencies
  working with the communities to set up the basis
  for subsequent studies the onset of relationship
  between malnutrition and infectious diseases.

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• Mycoses the incorporation of molecular
  tools for characterization of fungi, the upgrade
  of research conditions that will allow blending
  of conventional and robust mycology with the
  modern molecular biology approach.

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• Tegumentary leishmaniasis transfer of
  molecular biology methods to other components
  detection and characterization of Leishmania
  without the need of culture but using molecular
  tools onset of gene expression studies to study
  pathogen virulence factors to set up an animal
  model to study the effect of Vitamin A on disease
  progression.

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• Tuberculosis and Buruli ulcer safety
  laboratory upgrade to work with drug resistant M.
  tuberculosis strains adaptation of drug
  resistant diagnostic procedures the onset of
  molecular characterization studies here in Lima
  (2002).

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Working Travels
These were major instruments for DGIS project
progress. They occur at three different levels
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Coordination meetings at both institutional and
specific component levels. Short visits for
technological transfer from the IMT to the IMTAvH
or for learning specific skills at the
IMT. Long training periods within a post
graduate program aimed to achieve a title.
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Common Activities and Core Facilities Natural
project evolution from the vertical approach to
the horizontal networking. Two major products
can be identified in terms of synergic
integration. Following temporal order
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Laboratory Laboratory Technological
transfer of molecular characterization tools to
Mycology and Mycobacterium units Clinical
Laboratory Skin ulcer and TBC clinical
studies
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Two major products can be identified in terms of
research power up grade PCR
room Cryobanking room
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PCR room
It will permit to use common equipment like
thermocyclers, electrophoresis apparatus, image
recording and to carry out amplicons manipulation
under good practice rules to avoid DNA
contamination and achieve reliable data
acquisition. This is crucial when you work with
patient sample material that is very difficult to
collect and almost always there is no possibility
to obtain a second sample from him/her.
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Cryobanking room To storage valuable
biomedical sample material for intra and extra
mural research groups, keeping the higher
cryobanking standards. A strategic instrument
for leverage inter institutional collaboration.
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The first step towards a Biological Resource
Center in collaboration with the BCCM/IHEM fungal
collection of the Scientific Institute of Public
Health, Brussels-Belgium. This will mean to
carry out activities to incorporate intellectual
and proprietary rights aspects.
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Next Step Towards research for the comprehensive
understanding of the Reality, where disease is a
manifestation of environment-pathogen-host
interactions
EPIDEMIOLOGY Clinics - Laboratory
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DGIS Funding 1998-2002
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Percentage of BEF/year devoted to Lima and
Antwerp
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Final Percentage Received by IMTAvH and ITMA
(1998-2002)
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Funding Percentage in Lima (1998-2002)
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Funding Percentage in Antwerp (1998-2002)
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Full Percentage Distribution According Components
(1998-2002)
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BEF for each Component per year