Avian Influenza Virus H5N1 Polymerase Subunit PB2 Capbinding Site Inhibitors

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Avian Influenza Virus H5N1 Polymerase Subunit PB2
Cap-binding Site Inhibitors

• Lihua (Vicky) Yang
• Universiti Sains Malaysia
• July 19, 2008

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Progress

• AutoDock3 tutorial
• Docking H3N2 PB2 active site to its natural
  ligand, mGTP
• Building H5N1 PB2 active site model using MODELLER

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Plans for the next two weeks

• Finish building H5N1 model
• Dock H5N1 active site with its natural ligand,
  mGTP
• Dock H5N1 active site with NCBI Diversity Set and
  the Malaysian library of compounds
• Analyze top hits

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Cultural Experience