Biovision s'r'o'

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Biovision s.r.o.

• Prague, Czech Republic

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Biovision MISSION

• Development and Commercialization
• of advanced biomimetic products for
  ophthalmology and eye surgery

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Legacy of Professor Otto WichterleBIOMIMETIC
IMPLANTS!

• World-renowned polymer scientist
• Inventor of NYLON 6 in late 1930s
• Inventor of biomedical hydrogels (HYDRON, WIGEL,
  etc) in early 1960s
• Inventor of soft contact lenses in 1965
• Inventor of spin casting and meniscus casting
  technologies
• Biomimetic IOL design (WIOL)
• Mentor of many scientists of biomimetic school in
  Prague (Vacik, Sulc, Stoys, Kopecek, )

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Biovision Modus Operandi

• Focus on Research and Development
• Essential company structure with minimum overhead
• Product development through a network of
  subcontractors, consultants and affiliates
• Base of operations in the Czech Republic
• Marketing target worldwide through Strategic
  partners, licensees and distributors

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Biovision Proprietary Technologies

• Biomimetic surfaces
• Biomimetic hydrogels
• Meniscus casting of lenses
• IOL Designs (full-disc PC lens, haptic-less AC
  lens, Accommodative optics for IOLs, )
• Memory materials for small incision implantation
• Thin-layer (or 2D) optics

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Intellectual Property Rights(exclusive for
ophthalmic implants outside Mid-and East Europe)

• Portfolio of patents sublicensed from Academy of
  Sciences, Czech Republic
• Portfolio of patens sublicensed from Replication
  Medical Inc. for ophthalmic implants
• Portfolio of patents licensed from S.K.Y.
  Polymers, Inc. for use in ophthalmic implants

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Biovision Technology

• Patents Status
• Hydrogels 3 Granted Manufacturing
• 1 Pending Clinically tested
• Biomimetic surfaces 4 Granted Laboratory
• Animal tested
• Lens manufacturing 4 Granted In production
• 1 pending Scale-up ready
• Lens design 2 Granted Completed for PC
• 2 Pending Prototype for AC
• Optical design 2 Pending Prototypes

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Biomimetic Surfaces

• No protein adsorption
• No attachment, adhesion or spreading of cells
• No recognition by immune system
• Applicable to hydrophilic or hydrophobic polymers
• No degradation of optical properties
• Several patents granted

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Biomimetic Hydrogels

• Low irreversible protein adsorption
• No attachment or adhesion of cells
• Low foreign body reaction
• Good mechanical properties at high hydration
• Shape memory properties
• Several patents granted and pending

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Meniscus Casting of lenses

• Modified spin casting
• Lens made in a single operation
• No mechanical operations needed
• Minimized contamination
• Applicable to focusing, dispersive, monofocal,
  polyfocal, aspheric or toric lenses
• Several patents granted or pending

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Meniscus Casting of lenses(cont.)

• MAIN ADVANTAGES
• High Biocompatibility
• Versatility (many materials and designs)
• Well tested technology
• Also precursors for machining
• Patent protection and extensive know-how

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Memory Lenses

• Lens shape optimized for implantation
• Incision size smaller than for foldable lenses
• Controllable return to indwelling shape (from
  seconds to minutes)
• Well tested concept
• Applicable to various biomaterials
• Protected by several patents

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THIN LAYER OPTICS (under development)

• Thickness 100 microns or less
• High resolution
• Low contrast degradation
• Low chromatic aberration
• Refractive power independent of geometry
• Refractive power same in air and water
• Monofocal, polyfocal or bifocal in whole optical
  area
• Patents in preparation

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Products areas

• WIOL accommodating posterior-chamber lenses for
  cataract and refractive surgery
• BAIOL Anterior Phakic Refractive Implant
• Derived products
• Veterinary cataract lens
• Anterior IOL for cataract surgery
• 2D Optics for licensing in other product areas
• Hydrillien cohesive gels and vitreous substitute
• Amniotic Membrane Substitute
• Tissue engineering for corneal healing

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WIOL-CF

• Posterior Chamber foldable hydrogel lens for
  cataract surgery
• Accommodating
• Highly biocompatible material
• Fills the posterior capsule
• Large lens implantable through small incision

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Phakic Refractive Implant (under development)

• Expected features and benefits
• Reversibility of surgery (re-implantable
  low-risk procedure)
• Small-incision procedure (lt 5 minutes in
  out-of-patient setting)
• Nearly instantaneous results (full next-day
  vision)
• Invisible in eye (no adverse effects in any
  light)
• No reflections or glare at night (night driving!)
• No iridectomy required (simpler procedure)
• No special surgical skills or equipment (low
  investment, short learning curve)

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Phakic Refractive Implant

• Derivatives
• Veterinary IOL (dog)
• serves as an animal model
• AC post-cataract IOL for developing countries
• Low demands on surgical infrastructure, skills
• No YAG required
• Low manufacturing cost

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Hydrillien associative hydrogels

• For cohesive gels in surgery
• and
• vitreous body replacement

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Ocular Surface Regeneration

• For corneal healing and resurfacing